-
作者：Nathanailidou, Patroula; Dhakshnamoorthy, Jothy; Xiao, Hua; Zofall, Martin; Holla, Sahana; O'Neill, Maura; Andresson, Thorkell; Wheeler, David; Grewal, Shiv I. S.
作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research
摘要：Heterochromatin, defined by histone H3 lysine 9 methylation (H3K9me), spreads across large domains and can be epigenetically inherited in a self- propagating manner. Heterochromatin propagation depends upon a read-write mechanism, where the Clr4/ Suv39h methyltransferase binds to preexisting trimethylated H3K9 (H3K9me3) and further deposits H3K9me. How the parental methylated histone template is preserved during DNA replication is not well understood. Here, we demonstrate using Schizosaccharom...
-
作者：Fedeles, Bogdan I.; Bhardwaj, Rishi; Ishikawa, Yasunobu; Khumsubdee, Sakunchai; Krappitz, Matteus; Gubina, Nina; Volpe, Isabel; Andrade, Denise C.; Westergerling, Parisa; Staudner, Tobias; Campolo, Jake; Liu, Sally S.; Dong, Ke; Cai, Yiqiang; Rehman, Michael; Gallagher, Anna-Rachel; Ruchirawat, Somsak; Croy, Robert G.; Essigmann, John M.; V. Fedeles, Sorin; Somlo, Stefan
作者单位：Saint Joseph's University; University of Freiburg; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Yale University; Chulabhorn Research Institute; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Theoretical & Experimental Biophysics; University of Erlangen Nuremberg
摘要：Autosomal dominant polycystic kidney disease (ADPKD) is the most common mono-genic cause of chronic kidney disease and the fourth leading cause of end- stage kidney disease, accounting for over 50% of prevalent cases requiring renal replacement therapy. There is a pressing need for improved therapy for ADPKD. Recent insights into the pathophysiology of ADPKD revealed that cyst cells undergo metabolic changes that up- regulate aerobic glycolysis in lieu of mitochondrial respiration for energy p...
-
作者：Beurga, Maryline; Schwalbacha, Evan Travis; Fettiplace, Robert
作者单位：University of Wisconsin System; University of Wisconsin Madison
摘要：During auditory transduction, sound- evoked vibrations of the hair cell stereociliary bundles open mechanotransducer (MET) ion channels via tip links extending from one stereocilium to its neighbor. How tension in the tip link is delivered to the channel is not fully understood. The MET channel comprises a pore- forming subunit, transmembrane channel- like protein (TMC1 or TMC2), aided by several accessory proteins, including LHFPL5 (lipoma HMGIC fusion partner- like 5). We investigated the ro...
-
作者：Hauer, Mathew E.; Jacobs, Sunshine A.; Kulp, Scott A.
作者单位：State University System of Florida; Florida State University; State University System of Florida; Florida State University
摘要：The warnings of potential climate migration first appeared in the scientific literature in the late 1970s when increased recognition that disintegrating ice sheets could drive people to migrate from coastal cities. Since that time, scientists have modeled potential climate migration without integrating other population processes, potentially obscuring the demographic amplification of this migration. Climate migration could amplify demographic change-enhancing migration to destinations and supp...
-
作者：Li, Jia- Ye; Liu, Fan; Xu, Jing; Kim, Ye-Jin; Kwon, Oh-Hoon; Xia, Bin; Wang, Huan; Granick, Steve
作者单位：Peking University; Peking University; Ulsan National Institute of Science & Technology (UNIST); Institute for Basic Science - Korea (IBS); University of Massachusetts System; University of Massachusetts Amherst
摘要：Assessing the ergodicity of graphene liquid cell electron microscope measurements, we report that loop states of circular DNA interconvert reversibly and that loop numbers fol-low the Boltzmann distribution expected for this molecule in bulk solution, provided that the electron dose is low (80- keV electron energy and electron dose rate 1-20 e(-) angstrom(-2) s(-1)). This imaging technique appears to act as a slow motion camera that reveals equilibrated distributions by imaging the time averag...
-
作者：Mahmoudabadbozchelou, Mohammadamin; Kamani, Krutarth M.; Rogers, Simon A.; Jamali, Safa
作者单位：Northeastern University; University of Illinois System; University of Illinois Urbana-Champaign
摘要：The ability to concisely describe the dynamical behavior of soft materials through closed-form constitutive relations holds the key to accelerated and informed design materials and processes. The conventional approach is to construct constitutive relations through simplifying assumptions and approximating the time-and rate dependent stress response of a complex fluid to an imposed deformation. While traditional frameworks have been foundational to our current understanding of soft materials, t...
-
作者：Su, Hanrui; Hu, Yun Hang
作者单位：Michigan Technological University
摘要：Converting hydrocarbons and greenhouse gases (i.e., carbon dioxide, CO2) directly into electricity through fuel cells at intermediate temperatures (450 to 550(degrees)C) remains a significant challenge, primarily due to the sluggish activation of C-H and C=O bonds. Here, we demonstrated a unique strategy to address this issue, in which light illumination was introduced into the thermal catalytic CO2 reforming of ethane in the anode as a unique thermo-photo anode process for carbonate- superstr...
-
作者：Chhabra, Gagan; Ahmad, Nihal
作者单位：University of Wisconsin System; University of Wisconsin Madison
-
作者：D'Alessandro, Angelo; Earley, Eric J.; Nemkov, Travis; Stephenson, Daniel; Dzieciatkowska, Monika; Hansen, Kirk C.; Minetti, Giampaolo; Champigneulle, Benoit; Stauffer, Emeric; Pichon, Aurelien; Furian, Michael; Verges, Samuel; Kleinman, Steven; Norris, Philip J.; Busch, Michael P.; Page, Grier P.; Kaestner, Lars
作者单位：University of Colorado System; University of Colorado Anschutz Medical Campus; Research Triangle Institute; University of Pavia; Communaute Universite Grenoble Alpes; Universite Grenoble Alpes (UGA); Institut National de la Sante et de la Recherche Medicale (Inserm); Institut National de la Sante et de la Recherche Medicale (Inserm); Universite Claude Bernard Lyon 1; Universite de Poitiers; University of Zurich; University of British Columbia; Vitalant; Vitalant Research Institute; Saarland University
摘要：Red blood cell (RBC) metabolic reprogramming upon exposure to high altitude contributes to physiological human adaptations to hypoxia, a multifaceted process critical to health and disease. To delve into the molecular underpinnings of this phenomenon, first, we performed a multi- omics analysis of RBCs from six lowlanders after exposure to high- altitude hypoxia, with longitudinal sampling at baseline, upon ascent to 5,100 m and descent to sea level. Results highlighted an association between ...
-
作者：Verzhbinsky, Ilya A.; Rubin, Daniel B.; Kajfez, Sophie; Bu, Yiting; Kelemen, Jessica N.; Kapitonava, Anastasia; Williams, Ziv M.; Hochberg, Leigh R.; Cash, Sydney S.; Halgren, Eric
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; University of California System; University of California San Diego; University of California System; University of California San Diego; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Brown University; Brown University
摘要：How the human cortex integrates (binds) information encoded by spatially distributed neurons remains largely unknown. One hypothesis suggests that synchronous bursts of high- frequency oscillations (ripples) contribute to binding by facilitating integration of neuronal firing across different cortical locations. While studies have demonstrated that ripples modulate local activity in the cortex, it is not known whether their co- occurrence coordinates neural firing across larger distances. We t...
