2024

最新文章

• Causal functional maps of brain rhythms in working memory AI翻译
  作者：Wischnewski, Miles; Berger, Taylor A.; Opitz, Alexander; Alekseichuk, Ivan
  作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Groningen
  摘要：Human working memory is a key cognitive process that engages multiple functional anatomical nodes across the brain. Despite a plethora of correlative neuroimaging evidence regarding the working memory architecture, our understanding of critical hubs causally controlling overall performance is incomplete. Causal interpretation requires cognitive testing following safe, temporal, and controllable neuromodulation of specific functional anatomical nodes. Such experiments became available in health...
• Ab initio generalized Langevin equation AI翻译
  作者：Xie, Pinchen; Car, Roberto; Weinan, E.
  作者单位：Princeton University; Princeton University; Princeton University; Princeton University; Peking University; Peking University
  摘要：We introduce a machine learning-based approach called ab initio generalized Langevin equation (AIGLE) to model the dynamics of slow collective variables (CVs) in materials and molecules. In this scheme, the parameters are learned from atomistic simulations based on ab initio quantum mechanical models. Force field, memory kernel, and noise generator are constructed in the context of the Mori-Zwanzig formalism, under the constraint of the fluctuation-dissipation theorem. Combined with deep poten...
• Luminal transport through intact endoplasmic reticulum limits the magnitude of localized Ca2+signals AI翻译
  作者：Crapart, Cecile C.; Scott, Zubenelgenubi C.; Konno, Tasuku; Sharma, Aman; Parutto, Pierre; Bailey, David M. D.; Westrate, Laura M.; Avezov, Edward; Koslover, Elena F.
  作者单位：University of Cambridge; University of Cambridge; University of California System; University of California San Diego; Calvin University
  摘要：The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching throughout the cell. Understanding how ER functionality relies on its structural organization is crucial for elucidating cellular vulnerability to ER perturbations, which have been implicated in several neuronal pathologies. One of the key functions of the ER is enabling Ca2+ signaling by storing large quantities of this ion and releasing it into the cytoplasm in a spatiotemporally controlled manner. Through a...
• Tapered chiral nanoparticles as broad- spectrum thermally stable antivirals for SARS-CoV-2 variants AI翻译
  作者：Gao, Rui; Xu, Xinxin; Kumar, Prashant; Liu, Ye; Zhang, Hongyu; Guo, Xiao; Sun, Maozhong; Colombari, Felippe Mariano; Moura, Andre F. de; Hao, Changlong; Ma, Jessica; Emre, Emine Sumeyra Turali; Cha, Minjeong; Xu, Liguang; Kuang, Hua; Kotov, Nicholas A.; Xu, Chuanlai
  作者单位：Jiangnan University; Jiangnan University; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Institute of Medical Biology - CAMS; Universidade Federal de Sao Carlos; University of Michigan System; University of Michigan
  摘要：The incessant mutations of viruses, variable immune responses, and likely emergence of new viral threats necessitate multiple approaches to novel antiviral therapeutics. Furthermore, the new antiviral agents should have broad- spectrum activity and be environmentally stable. Here, we show that biocompatible tapered CuS nanoparticles (NPs) efficiently agglutinate coronaviruses with binding affinity dependent on the chirality of surface ligands and particle shape. L- penicillamine- stabilized NP...
• Phenotypic screen of sixty- eight colorectal cancer cell lines identifies CEACAM6 and CEACAM5 as markers of acid resistance AI翻译
  作者：Michl, Johanna; White, Bobby; Monterisi, Stefania; Bodmer, Walter F.; Swietach, Pawel
  作者单位：University of Oxford; University of Oxford
  摘要：Elevated cancer metabolism releases lactic acid and CO2 into the under- perfused tumor microenvironment, resulting in extracellular acidosis. The surviving cancer cells must adapt to this selection pressure; thus, targeting tumor acidosis is a rational therapeutic strategy to manage tumor growth. However, none of the major approved treatments are based explicitly on disrupting acid handling, signaling, or adaptations, possibly because the distinction between acid- sensitive and acid- resistant...
• Myosin-5 varies its step length to carry cargo straight along the irregular F-actin track AI翻译
  作者：Fineberga, Adam; Takagi, Yasuharu; Thirumurugan, Kavitha; Andrecka, Joanna; Billingtonc, Neil; Young, Gavin; Cole, Daniel; Burgess, Stan A.; Curd, Alistair P.; Hammer, John A.; Sellers, James R.; Kukura, Philipp; Knight, Peter J.
  作者单位：Vellore Institute of Technology (VIT); VIT Vellore; Human Technopole; West Virginia University; University of Oxford; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Leeds; University of Leeds; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI); University of Oxford
  摘要：Molecular motors employ chemical energy to generate unidirectional mechanical output against a track while navigating a chaotic cellular environment, potential disorder on the track, and against Brownian motion. Nevertheless, decades of nanometer -precise optical studies suggest that myosin -5a, one of the prototypical molecular motors, takes uniform steps spanning 13 subunits (36 nm) along its F-actin track. Here, we use high -resolution interferometric scattering microscopy to reveal that my...
• To be policy- relevant, future climate research must include the noncontiguous United States AI翻译
  作者：Basile, Samantha; Avery, Christopher W.; Grade, Aaron; Crimmins, Allison R.
• Aerosolization of viable Mycobacterium tuberculosis bacilli by tuberculosis clinic attendees independent of sputum-Xpert Ultra status AI翻译
  作者：Patterson, Benjamin; Dinkele, Ryan; Gessner, Sophia; Koch, Anastasia; Hoosen, Zeenat; January, Vanessa; Leonard, Bryan; Mckerry, Andrea; Seldon, Ronnett; Vazi, Andiswa; Hermans, Sabine; Cobelens, Frank; Warner, Digby F.; Wood, Robin
  作者单位：University of Amsterdam; South African Medical Research Council; University of Cape Town; University of Cape Town; National Research Foundation - South Africa; University of Cape Town; University of Cape Town
  摘要：Potential Mycobacterium tuberculosis (Mtb) transmission during different pulmonary tuberculosis (TB) disease states is poorly understood. We quantified viable aerosolized Mtb from TB clinic attendees following diagnosis and through six months' follow-up thereafter. Presumptive TB patients (n=102) were classified by laboratory, radiological, and clinical features into Group A: Sputum-Xpert Ultra-positive TB (n=52), Group B: Sputum-Xpert Ultra-negative TB (n=20), or Group C: TB undiagnosed (n=30...
• Decoupling of bird migration from the changing phenology of spring green- up AI翻译
  作者：Robertson, Ellen P.; La Sorte, Frank A.; Taillie, Paul J.; Mays, Jonathan D.; Robinson, Orin J.; Ansley, Robert J.; O'Connell, Timothy J.; Davis, Craig A.; Loss, Scott R.
  作者单位：Oklahoma State University System; Oklahoma State University - Stillwater; Yale University; Yale University; Florida Fish & Wildlife Conservation Commission; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Cornell University
  摘要：The green - up of vegetation in spring brings a pulse of food resources that many animals track during migration. However, green - up phenology is changing with climate change, posing an immense challenge for species that time their migrations to coincide with these resource pulses. We evaluated changes in green - up phenology from 2002 to 2021 in relation to the migrations of 150 Western- Hemisphere bird species using eBird citizen science data. We found that green - up phenology has changed ...
• Higher total energy costs strain the elderly, especially low- income, across 31 developed countries AI翻译
  作者：Tian, Peipei; Feng, Kuishuang; Sun, Laixiang; Hubacek, Klaus; Malerba, Daniele; Zhong, Honglin; Zheng, Heran; Li, Dan; Zhang, Ning; Li, Jiashuo
  作者单位：Shandong University; University System of Maryland; University of Maryland College Park; University of London; University of London School Oriental & African Studies (SOAS); University of Groningen; University of London; University College London; University of Cambridge
  摘要：Addressing the total energy cost burden of elderly people is essential for designing equitable and effective energy policies, especially in responding to energy crisis in an aging society. It is due to the double impact of energy price hikes on households-through direct impact on fuel bills and indirect impact on the prices of goods and services consumed. However, while examining the household energy cost burden of the elderly, their indirect energy consumption and associated cost burden remai...