-
作者：Wang, Rui; Lei, Huan; Wang, Hongxiang; Qi, Lei; Liu, Yu'e; Liu, Yunhui; Shi, Yufeng; Chen, Juxiang; Shen, Qing-Tao
作者单位：Southern University of Science & Technology; Laoshan Laboratory; Southern University of Science & Technology; Naval Medical University; Shandong University; Tongji University; Tongji University
摘要：Glioblastomas (GBMs) are the most lethal primary brain tumors with limited survival, even under aggressive treatments. The current therapeutics for GBMs are flawed due to the failure to accurately discriminate between normal proliferating cells and distinctive tumor cells. Mitochondria are essential to GBMs and serve as potential therapeutical targets. Here, we utilize cryo- electron tomography to quantitatively investigate nanoscale details of randomly sampled mitochondria in their native cel...
-
作者：Aguilar-Velazquez, Daniel; Islas, Ivan Rivera; Tecua, Guillermo Romero; Valenzuela-Aguilera, Alfonso
作者单位：Instituto Politecnico Nacional - Mexico; Universidad Autonoma del Estado de Morelos
摘要：We conducted a spatial and temporal analysis of housing patterns in Mexico City by utilizing an extensive database of 16,000 prices for flats and houses, covering the period from 2000 to 2022. Our findings reveal a striking trend: The average housing prices have quadrupled over a 20-y period, without considering inflation. In contrast, the per capita labor income of Mexican citizens has declined relative to inflation. As a result, the average family encountered four times greater challenges in...
-
作者：Rains, Stephen A.; Richards, Adam S.
作者单位：University of Arizona
摘要：During the COVID- 19 pandemic, some US states mandated vaccination for certain citizens. We used state- level data from the CDC to test whether vaccine mandates predicted changes in COVID- 19 vaccine uptake, as well as related voluntary behaviors involving COVID- 19 boosters and seasonal influenza vaccines. Results showed that COVID- 19 vaccine adoption did not significantly change in the weeks before and after states implemented vaccine mandates, suggesting that mandates did not directly impa...
-
作者：Dong, Bo; Wang, Xinzhao; Song, Xiang; Wang, Jianlin; Liu, Xia; Yu, Zhiyong; Zhou, Yongkun; Deng, Jiong; Wu, Yadi
作者单位：University of Kentucky; University of Kentucky; Shandong University; Shandong First Medical University & Shandong Academy of Medical Sciences; University of Jinan; Shandong University of Traditional Chinese Medicine; Binzhou Medical University
摘要：Cyclin- dependent kinase 9 (CDK9) plays a critical role in transcription initiation and is essential for maintaining gene silencing at heterochromatic loci. Inhibition of CDK9 increases sensitivity to immunotherapy, but the underlying mechanism remains unclear. We now report that RNF20 stabilizes LSD1 via K29- mediated ubiquitination, which is dependent on CDK9- mediated phosphorylation. This CDK9- and RNF20- dependent LSD1 stabilization is necessary for the demethylation of histone H3K4, then...
-
作者：Yu, Jinhan; Daru, Andrea; Deng, Min; Blackmond, Donna G.
作者单位：University of Chicago; Scripps Research Institute
摘要：The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic amino acids. The enzymatic transamination cycles that are key to modern biochemical formation of enantiopure amino acids may have evolved from this half of the reversible reaction couple. Kinetic resolution of racemic precursors emerges as a general route to enantioenrichment under prebiotic conditions. Significance While much progress has...
-
作者：Springstein, Benjamin L.; Paulo, Joao A.; Park, Hankum; Henry, Kemardo; Fleming, Eleanor; Feder, Zoe; Harper, J. Wade; Hochschild, Ann; Zaher, Hani S.
作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard Medical School; Institute of Science & Technology - Austria; Seoul National University (SNU); Seoul National University (SNU)
摘要：The synthesis of proteins as encoded in the genome depends critically on translational fidelity. Nevertheless, errors inevitably occur, and those that result in reading frame shifts are particularly consequential because the resulting polypeptides are typically nonfunctional. Despite the generally maladaptive impact of such errors, the proper decoding of certain mRNAs, including many viral mRNAs, depends on a process known as programmed ribosomal frameshifting. The fact that these programmed e...
-
作者：Xu, Zhao- Hua; Xu, Su; Qian, Chao; Xu, Wenya; Ren, Hang; Su, Wenming; Chen, Qi- Dai; Chen, Hongsheng; Sun, Hong - Bo
作者单位：Jilin University; Zhejiang University; Zhejiang University; Zhejiang University; Chinese Academy of Sciences; Suzhou Institute of Nano-Tech & Nano-Bionics, CAS; Tsinghua University
摘要：Invisibility, a fascinating ability of hiding objects within environments, has attracted broad interest for a long time. However, current invisibility technologies are still restricted to stationary environments and narrow band. Here, we experimentally demonstrate a Chimera metasurface for multiterrain invisibility by synthesizing the natural camouflage traits of various poikilotherms. The metasurface achieves chameleon - like broadband in situ tunable microwave reflection mimicry of realistic...
-
作者：Ornes, Stephen
-
作者：Parsons, Todd L.; Bolker, Benjamin M.; Dushoff, Jonathan; Earn, David J. D.
作者单位：Universite Paris Cite; Sorbonne Universite; McMaster University; McMaster University; McMaster University
摘要：We present an approach to computing the probability of epidemic burnout, i.e., the probability that a newly emergent pathogen will go extinct after a major epidemic. Our analysis is based on the standard stochastic formulation of the Susceptible -InfectiousRemoved (SIR) epidemic model including host demography (births and deaths) and corresponds to the standard SIR ordinary differential equations (ODEs) in the infinite population limit. Exploiting a boundary layer approximation to the ODEs and...
-
作者：Zhang, Bingsen; Yu, Yan; Fox, Bennett W.; Liu, Yinong; Thirumalaikumar, Venkatesh P.; Skirycz, Aleksandra; Lin, Hening; Schroedera, Frank C.
作者单位：Cornell University; Boyce Thompson Institute for Plant Research; Cornell University; Howard Hughes Medical Institute; Cornell University; Cornell University
摘要：Protein lipidation plays critical roles in regulating protein function and localization. However, the chemical diversity and specificity of fatty acyl group utilization have not been investigated using untargeted approaches, and it is unclear to what extent structures and biosynthetic origins of S-acyl moieties differ from N- and O - fatty acylation. Here, we show that fatty acylation patterns in Caenorhabditis elegans differ markedly between different amino acid residues. Hydroxylamine captur...
