2024

最新文章

• The clustered gamma protocadherin PcdhγC4 isoform regulates cortical interneuron programmed cell death in the mouse cortex AI翻译
  作者：Leon, Walter R. Mancia; Steffen, David M.; Dale-Huang, Fiona R.; Rakela, Benjamin; Breevoort, Arnar; Romero-Rodriguez, Ricardo; Hasenstaub, Andrea R.; Stryker, Michael P.; Weiner, Joshua A.; Alvarez-Buylla, Arturo
  作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of Iowa; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
  摘要：Cortical inhibitory interneurons (cINs) are born in the ventral forebrain and migrate into the cortex where they make connections with locally produced excitatory glutamatergic neurons. Cortical function critically depends on the number of cINs, which is also key to establishing the appropriate inhibitory/excitatory balance. The final number of cINs is determined during a postnatal period of programmed cell death (PCD) when similar to 40% of the young cINs are eliminated. Previous work shows t...
• Reassessing the role of urban green space in air pollution control AI翻译
  作者：Venter, Zander S.; Hassani, Amirhossein; Stange, Erik; Schneider, Philipp; Castell, Nuria
  作者单位：Norwegian Institute Nature Research; NILU
  摘要：The assumption that vegetation improves air quality is prevalent in scientific, popular, and political discourse. However, experimental and modeling studies show the effect of green space on air pollutant concentrations in urban settings is highly variable and context specific. We revisited the link between vegetation and air quality using satellite- derived changes of urban green space and air pollutant concentrations from 2,615 established monitoring stations over Europe and the United State...
• Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix AI翻译
  作者：Liu, Heng; Cui, Yunpeng; Zhao, Xue; Wei, Lulu; Wang, Xudong; Shen, Ning; Odom, Timothy; Li, Xuming; Lawless, William; Karunarathne, Kanchana; Muschol, Martin; Guida, Wayne; Cao, Chuanhai; Ye, Libin; Cai, Jianfeng
  作者单位：State University System of Florida; University of South Florida; State University System of Florida; University of South Florida; State University System of Florida; University of South Florida; State University System of Florida; University of South Florida
  摘要：In contrast to prevalent strategies which make use of beta-sheet mimetics to block A beta fibrillar growth, in this study, we designed a series of sulfonyl-gamma-AApeptide helices that targeted the crucial alpha-helix domain of A beta 13-26 and stabilized A beta conformation to avoid forming the neurotoxic A beta oligomeric beta-sheets. Biophysical assays such as amyloid kinetics and TEM demonstrated that the A beta oligomerization and fibrillation could be greatly prevented and even reversed ...
• Profile of Pierre Agostini, Anne L'Huillier, and Ferenc Krausz: 2023 Nobel laureates in physics AI翻译
  作者：Leone, Stephen R.
• Single- particle imaging of nanomedicine entering the brain AI翻译
  作者：Wei, Mian; Qian, Naixin; Gao, Xin; Lang, Xiaoqi; Song, Donghui; Min, Wei
  作者单位：Columbia University; Columbia University; Columbia University
  摘要：Nanomedicine has emerged as a revolutionary strategy of drug delivery. However, fundamentals of the nano-neuro interaction are elusive. In particular, whether nanocarriers can cross the blood-brain barrier (BBB) and release the drug cargo inside the brain, a basic process depicted in numerous books and reviews, remains controversial. Here, we develop an optical method, based on stimulated Raman scattering, for imaging nanocarriers in tissues. Our method achieves a suite of capabilities-single-...
• Genetic transformation of the frog-killing chytrid fungus Batrachochytrium dendrobatidis AI翻译
  作者：Kalinka, Erik; Brody, Stephanie M.; Swafford, Andrew J. M.; Medina, Edgar M.; Fritz-Laylin, Lillian K.
  作者单位：University of Massachusetts System; University of Massachusetts Amherst
  摘要：Batrachochytrium dendrobatidis (Bd), a causative agent of chytridiomycosis, is decimating amphibian populations around the world. Bd belongs to the chytrid lineage, a group of early-diverging fungi that are widely used to study fungal evolution. Like all chytrids, Bd develops from a motile form into a sessile, growth form, a transition that involves drastic changes in its cytoskeletal architecture. Efforts to study Bd cell biology, development, and pathogenicity have been limited by the lack o...
• Structure of saguaro cactus virus 3′ translational enhancer mimics 5′ cap for eIF4E binding AI翻译
  作者：Ojha, Manju; Vogt, Jeff; Das, Naba Krishna; Redmond, Emily; Singh, Karndeep; Al Banna, Hasan; Sadat, Tasnia; Koirala, Deepak
  作者单位：University System of Maryland; University of Maryland Baltimore County; Howard Hughes Medical Institute; University System of Maryland; University of Maryland Baltimore County
  摘要：The genomes of several plant viruses contain RNA structures at their 3 ' ends called cap-independent translation enhancers (CITEs) that bind the host protein factors such as mRNA 5 ' cap-binding protein eIF4E for promoting cap-independent genome translation. However, the structural basis of such 5 ' cap-binding protein recognition by the uncapped RNA remains largely unknown. Here, we have determined the crystal structure of a 3 ' CITE, panicum mosaic virus-like translation enhancer (PTE) from ...
• Sm complex assembly and 5′ cap trimethylation promote selective processing of snRNAs by the 3′ exonuclease TOE1 AI翻译
  作者：Ma, Tiantai; Xiong, Erica S.; Lardelli, Rea M.; Lykke- Andersen, Jens
  作者单位：University of California System; University of California San Diego
  摘要：Competing exonucleases that promote 3 ' end maturation or degradation direct quality control of small non- coding RNAs, but how these enzymes distinguish normal from aberrant RNAs is poorly understood. The Pontocerebellar Hypoplasia 7 (PCH7)-associated 3 ' exonuclease TOE1 promotes maturation of canonical small nuclear RNAs (snRNAs). Here, we demonstrate that TOE1 achieves specificity toward canonical snRNAs through their Sm complex assembly and cap trimethylation, two features that distinguis...
• If psychedelics heal, how do they do it? AI翻译
  作者：Beans, Carolyn
• Development of 2nd generation aminomethyl spectinomycins that overcome native efflux in Mycobacterium abscessus AI翻译
  作者：Phelps, Gregory A.; Cheramie, Martin N.; Fernando, Dinesh M.; Selchow, Petra; Meyer, Christopher J.; Waidyarachchi, Samanthi L.; Dharuman, Suresh; Liu, Jiuyu; Meuli, Michael; Dal Molin, Michael; Killam, Benjamin Y.; Murphy, Patricia A.; Reeve, Stephanie M.; Wilt, Laura A.; Anderson, Shelby M.; Yang, Lei; Lee, Robin B.; Temrikar, Zaid H.; Lukka, Pradeep B.; Meibohm, Bernd; Polikanov, Yury S.; Hobbie, Sven N.; Bottger, Erik C.; Sander, Peter; Lee, Richard E.
  作者单位：St Jude Children's Research Hospital; St Jude Children's Research Hospital; University of Zurich; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Tennessee System; University of Tennessee Health Science Center; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Illinois System; University of Illinois Chicago; University of Illinois Chicago Hospital; University of Cologne
  摘要：Mycobacterium abscessus (Mab), a nontuberculous mycobacterial (NTM) species, is an emerging pathogen with high intrinsic drug resistance. Current standard- of- care therapy results in poor outcomes, demonstrating the urgent need to develop effective antimycobacterial regimens. Through synthetic modification of spectinomycin (SPC), we have identified a distinct structural subclass of N- ethylene linked aminomethyl SPCs (eAmSPCs) that are up to 64- fold more potent against Mab over the parent SP...