2024

最新文章

• Genomes, fossils, and the concurrent rise of modern birds and flowering plants in the Late Cretaceous AI翻译
  作者：Wu, Shaoyuan; Rheindt, Frank E.; Zhang, Jin; Wang, Jiajia; Zhang, Lei; Quan, Cheng; Li, Zhiheng; Wang, Min; Wu, Feixiang; Qu, Yanhua; Edwards, Scott, V; Zhou, Zhonghe; Liu, Liang
  作者单位：Jiangsu Normal University; National University of Singapore; Changsha University of Science & Technology; Chang'an University; Chinese Academy of Sciences; Institute of Vertebrate Paleontology & Paleoanthropology, CAS; Chinese Academy of Sciences; Institute of Zoology, CAS; Harvard University; University System of Georgia; University of Georgia
  摘要：The phylogeny and divergence timing of the Neoavian radiation remain controversial despite recent progress. We analyzed the genomes of 124 species across all Neoavian orders, using data from 25,460 loci spanning four DNA classes, including 5,756 coding sequences, 12,449 conserved nonexonic elements, 4,871 introns, and 2,384 intergenic segments. We conducted a comprehensive sensitivity analysis to account for the heterogeneity across different DNA classes, leading to an optimal tree of Neoaves ...
• Mutations of the circadian clock genes Cry, Per, or Bmal1have different effects on the transcribed and nontranscribed strands of cycling genes AI翻译
  作者：Yang, Yanyan; Wu, Gang; Sancar, Aziz; Hogenesch, John B.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center
  摘要：One important goal of circadian medicine is to apply time- of- day dosing to improve the efficacy of chemotherapy. However, limited knowledge of how the circadian clock regulates DNA repair presents a challenge to mechanism- based clinical application. We studied time- series genome- wide nucleotide excision repair in liver and kidney of wild type and three different clock mutant genotypes (Cry1-/-Cry2-/-, Per1-/-Per2-/-, and Bmal1-/-). Rhythmic repair on the nontranscribed strand was lost in ...
• Peer income exposure across the income distribution AI翻译
  作者：Spiegel, Michelle; Clark, Leah; Domina, Thurston; Penner, Emily K.; Hanselman, Paul; Yoo, Paul Y.; Penner, Andrew
  作者单位：Stanford University; University of North Carolina; University of North Carolina Chapel Hill; University of California System; University of California Irvine; University of California System; University of California Irvine
  摘要：Children from families across the income distribution attend public schools, making schools and classrooms potential sites for interaction between more- and less- affluent children. However, limited information exists regarding the extent of economic integration in these contexts. We merge educational administrative data from Oregon with measures of family income derived from IRS records to document student exposure to economically diverse school and classroom peers. Our findings indicate that...
• Virus- derived circular RNAs populate hepatitis C virus-infected cells AI翻译
  作者：Cao, Qian M.; Boonchuen, Pakpoom; Chen, Tzu-Chun; Lei, Shaohua; Somboonwiwat, Kunlaya; Sarnow, Peter
  作者单位：Stanford University; Suranaree University of Technology; Chulalongkorn University; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Natera, Inc.
  摘要：It is known that pre-mRNAs in eukaryotic cells can be processed to circular RNAs by a backsplicing mechanism. Circular RNAs have great stability and can sequester proteins or small RNAs to exert functions on cellular pathways. Because viruses often exploit host pathways, we explored whether the RNA genome of the cytoplasmic hepatitis C virus is processed to yield virus- derived circRNAs (vcircRNAs). Computational analyses of RNA-seq experiments predicted that the viral RNA genome is fragmented...
• Filament structure and subcellular organization of the bacterial intermediate filament-like protein crescentin AI翻译
  作者：Liu, Yue; van den Ent, Fusinita; Lowe, Jan
  作者单位：MRC Laboratory Molecular Biology; UK Research & Innovation (UKRI); Medical Research Council UK (MRC); Zhejiang University; Zhejiang University
  摘要：The protein crescentin is required for the crescent shape of the freshwater bacterium Caulobacter crescentus (vibrioides). Crescentin forms a filamentous structure on the inner, concave side of the curved cells. It shares features with eukaryotic intermediate filament (IF) proteins, including the formation of static filaments based on long and parallel coiled coils, the protein's length, structural roles in cell and organelle shape determination and the presence of a coiled coil discontinuity ...
• Lysosome- related organelles contain an expansion compartment that mediates delivery of zinc transporters to promote homeostasis AI翻译
  作者：Mendoza, Adelita D.; Dietrich, Nicholas; Tan, Chieh- Hsiang; Herrera, Daniel; Kasiah, Jennysue; Payne, Zachary; Cubillas, Ciro; Schneider, Daniel L.; Kornfeld, Kerry
  作者单位：Washington University (WUSTL); National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); California Institute of Technology
  摘要：Zinc is an essential nutrient-it is stored during periods of excess to promote detoxification and released during periods of deficiency to sustain function. Lysosome- related organelles (LROs) are an evolutionarily conserved site of zinc storage, but mechanisms that control the directional zinc flow necessary for homeostasis are not well understood. In Caenorhabditis elegans intestinal cells, the CDF-2 transporter stores zinc in LROs during excess. Here, we identify ZIPT-2.3 as the transporter...
• Characterizing pathways of seafood access in small island developing states AI翻译
  作者：Seto, Katherine L.; Friedman, Whitney R.; Eurich, Jacob G.; Gephart, Jessica A.; Mason, Jessica Zamborain -; Sharp, Michael; Aram, Erietera; Tekaieti, Aritita; Tekiau, Aranteiti; Golden, Christopher D.
  作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Barbara; American University; Harvard University; Harvard T.H. Chan School of Public Health; University of Wollongong
  摘要：Ensuring healthy and sustainable food systems in increasing social, economic, and ecological change is a key global priority to protect human and environmental health. Seafood is an essential component of these food systems and a critical source of nutrients, especially in coastal communities. However, despite rapid transformations in aquatic food systems, and our urgent need to understand them, there is a dearth of data connecting harvested food production to actualized food consumption. Many...
• Topology of molecular deformations induces triphasic catch bonding in selectin-ligand bonds AI翻译
  作者：Barkan, Casey O.; Bruinsma, Robijn F.
  作者单位：University of California System; University of California Los Angeles
  摘要：Among the long-standing efforts to elucidate the physical mechanisms of protein- ligand catch bonding, particular attention has been directed at the family of selectin proteins. Selectins exhibit slip, catch-slip, and slip-catch-slip bonding, with minor structural modifications causing major changes in selectins' response to force. How can a single structural mechanism allow interconversion between these various behaviors? We present a unifying theory of selectin-ligand catch bonding, using a ...
• Effects of climate, land use, and human population change on human-elephant conflict risk in Africa and Asia AI翻译
  作者：Guarnieri, Mia; Kumaishi, Grace; Brock, Cameryn; Chatterjee, Mayukh; Fabiano, Ezequiel; Adefowora, Roshni Katrak-; Larsen, Ashley; Lockmann, Taylor M.; Roehrdanz, Patrick R.
  作者单位：University of California System; University of California Santa Barbara; Conservation International; University of Namibia
  摘要：Human-wildlife conflict is an important factor in the modern biodiversity crisis and has negative effects on both humans and wildlife (such as property destruction, injury, or death) that can impede conservation efforts for threatened species. Effectively addressing conflict requires an understanding of where it is likely to occur, particularly as climate change shifts wildlife ranges and human activities globally. Here, we examine how projected shifts in cropland density, human population den...
• A large- effect fitness trade- off across environments is explained by a single mutation affecting cold acclimation AI翻译
  作者：Lee, Gwonjin; Sanderson, Brian J.; Ellis, Thomas J.; Dilkes, Brian P.; McKay, John K.; Agren, Jon; Oakley, Christopher G.
  作者单位：Purdue University System; Purdue University; Purdue University System; Purdue University; Uppsala University; Purdue University System; Purdue University; Colorado State University System; Colorado State University Fort Collins; State University System of Florida; University of Florida; University of Kansas; University of Kansas; Austrian Academy of Sciences; Vienna Biocenter (VBC); Gregor Mendel Institute of Molecular Plant Biology (GMI)
  摘要：Identifying the genetic basis of local adaptation and fitness trade - offs across environments is a central goal of evolutionary biology. Cold acclimation is an adaptive plastic response for surviving seasonal freezing, and costs of acclimation may be a general mechanism for fitness trade - offs across environments in temperate zone species. Starting with locally adapted ecotypes of Arabidopsis thaliana from Italy and Sweden, we examined the fitness consequences of a naturally occurring functi...