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作者：D'Angelo, Josephine C.; Tiruveedhula, Pavan; Weber, Raymond J.; Arathorn, David W.; Roorda, Austin
作者单位：University of California System; University of California Berkeley; Montana State University System; Montana State University Bozeman
摘要：Detecting the motion of an object relative to a world-fixed frame of reference is an exquisite human capability [G. E. Legge, F. Campbell, Vis. Res. 21 , 205-213 (1981)]. However, there is a special condition where humans are unable to accurately detect relative motion: Images moving in a direction consistent with retinal slip where the motion is unnaturally amplified can, under some conditions, appear stable [D. W. Arathorn, S. B. Stevenson, Q. Yang, P. Tiruveedhula, A. Roorda, J. Vis. 13 , 2...
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作者：Lin, Ai-Zhi; Fu, Xian; Jiang, Qing; Zhou, Xue; Hwang, Sung Hee; Yin, Hou-Hua; Ni, Kai-Di; Pan, Qing-Jin; He, Xin; Zhang, Ling-Tong; Meng, Yi-Wen; Liu, Ya-Nan; Hammock, Bruce D.; Liu, Jun-Yan
作者单位：Chongqing Medical University; Chongqing Medical University; University of California System; University of California Davis; University of California System; University of California Davis
摘要：Highsucrose diet (HSD) was reported as a causative factor for multiorgan injuries. The underlying mechanisms and therapeutic strategies remain largely uncharted. In the present study, by using a metabolomics approach, we identified the soluble epoxide hydrolase (sEH) as a therapeutic target for HSD- mediated gut barrier dysfunction. Specifically, 16- week feeding on an HSD caused gut barrier dysfunction, such as colon inflammation and tight junction impairment in a murine model. A metabolomics...
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作者：Feng, Yuge; Park, Yoon; Hao, Shaoyun; Fang, Zhiwei; Terlier, Tanguy; Zhang, Xiao; Qiu, Chang; Zhang, Shoukun; Chen, Fengyang; Zhu, Peng; Nguyen, Quan; Wang, Haotian; Biswal, Sibanilisa
作者单位：Rice University; Rice University; Rice University; Rice University; Rice University
摘要：Efficient lithium recovery from geothermal brines is crucial for the battery industry. Current electrochemical separation methods struggle with the simultaneous presence of Na+, K+, Mg2+, and Ca2+ because these cations are similar to Li+, making it challenging to separate effectively. We address these challenges with a three-chamber reactor featuring a polymer porous solid electrolyte in the middle layer. This design improves the transference number of Li+ (tLi+) by 2.1 times compared to the t...
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作者：Volkov, Leo I.; Ogawa, Yohey; Somjee, Ramiz; Vedder, Hannah E.; Powell, Hannah E.; Poria, Deepak; Meiselman, Sam; Kefalov, Vladimir J.; Corbo, Joseph C.
作者单位：Washington University (WUSTL); University of California System; University of California Irvine
摘要：The role of transcription factors in photoreceptor gene regulation is fairly well understood, but knowledge of the cell- type- specific function of transcriptional cofactors remains incomplete. Here, we show that the transcriptional corepressor samd7 promotes rod differentiation and represses short- wavelength cone genes in long- wavelength cones in zebrafish. In samd7-/- retinas, red cones are transformed into hybrid red/ultraviolet (UV) cones, green cones are absent, the number of blue cones...
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作者：Yuan, Yuan; Al Bulushi, Tahani; Sastry, Anand V.; Sancar, Cigdem; Szubin, Richard; Golden, Susan S.; Palsson, Bernhard O.
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作者：Lowman, Heili E.; Desiervo, Melissa; Hall Jr, Robert O.; Jahner, Joshua P.; Jimoh, Saheed O.; Laughlin, Daniel C.; Patterson, Amy C.; Lehman, Christopher Weiss-; Barbosa, Carolina C.; Bell, Katherine L.; Blaszczak, Joanna R.; Buerkle, C. Alex; Carter, Alice M.; Collins, Sarah M.; Deleo, Victoria; Dunkle, Matt; Gannon, Dustin; Grames, Eliza M.; Harrison, Joshua G.; Mcfarlane, S. Eryn; Oleksy, Isabella; Powers, Breanna F.; Ray, Courtenay; Stears, Alice; Summers, Betsy; Torrens, Christa L.; Trentman, Matt; Werner, Chhaya M.; Shoemaker, Lauren G.
作者单位：Nevada System of Higher Education (NSHE); University of Nevada Reno; University of Wyoming; Union College; University of Montana System; University of Montana; University of Wyoming; Colorado State University System; Colorado State University Fort Collins; Nevada System of Higher Education (NSHE); University of Nevada Reno; Oregon State University; State University of New York (SUNY) System; Binghamton University, SUNY; York University - Canada; University of Colorado System; University of Colorado Boulder; Northern Arizona University; Northern Arizona University; University of Montana System; University of Montana
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作者：Chen, Jiaxing; Hnath, Brianna; Sha, Congzhou M.; Beidler, Lynne; Schell, Todd D.; Dokholyan, Nikolay V.
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Penn State Health; Pennsylvania Commonwealth System of Higher Education (PCSHE); Pennsylvania State University; Pennsylvania State University - University Park
摘要：Chimeric antigen receptor T cell therapies have achieved great success in eradicating some liquid tumors, whereas the preclinical results in treating solid tumors have proven less decisive. One of the principal challenges in solid tumor treatment is the physical barrier composed of a dense extracellular matrix, which prevents immune cells from penetrating the tissue to attack intratumoral cancer cells. Here, we improve immune cell infiltration into solid tumors by manipulating septin-7 functio...
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作者：Cieslinskia, Pawel; Knips, Lukas; Kowalczyk, Mateusz; Laskowski, Wieshw; Paterek, Tomasz; Vertesi, Tamas; Weinfurter, Harald
作者单位：Fahrenheit Universities; University of Gdansk; Max Planck Society; University of Munich; Xiamen University Malaysia Campus; HUN-REN; HUN-REN Institute for Nuclear Research
摘要：Quantum mechanics imposes limits on the statistics of certain observables. Perhaps the most famous example is the uncertainty principle. Similar trade-offs also exist for the simultaneous violation of multiple Bell inequalities. In the simplest case of three observers, it has been shown that if two observers violate a Bell inequality, then none of them can violate any Bell inequality with the third observer, a property called monogamy of Bell violations. Forms of Bell monogamy have been linked...
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作者：Faizi, Hammad A.; Granek, Rony; Vlahovska, Petia M.
作者单位：Northwestern University; Ben-Gurion University of the Negev; Ben-Gurion University of the Negev; Northwestern University; Northwestern University; University of Chicago
摘要：The biological function of membranes is closely related to their softness, which is often studied through the membranes' thermally driven fluctuations. Typically, the analysis assumes that the relaxation rate of a pure bending deformation is determined by the competition between membrane bending rigidity and viscous dissipation in the surrounding medium. Here, we reexamine this assumption and demonstrate that viscous flows within the membrane dominate the dynamics of bending fluctuations of no...
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作者：Gay, Sean M.; Chartampila, Elissavet; Lord, Julia S.; Grizzard, Sawyer; Maisashvili, Tekla; Ye, Michael; Barker, Natalie K.; Mordant, Angie L.; Mills, C. Allie; Herring, Laura E.; Diering, Graham H.
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Sleep is an essential behavior that supports lifelong brain health and cognition. Neuronal synapses are a major target for restorative sleep function and a locus of dysfunction in response to sleep deprivation (SD). Synapse density is highly dynamic during development, becoming stabilized with maturation to adulthood, suggesting sleep exerts distinct synaptic functions between development and adulthood. Importantly, problems with sleep are common in neurodevelopmental disorders including autis...
