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作者：Lewin, Patrick J.; Wynn, Joe; Arcos, Jose Manuel; Austin, Rhiannon E.; Blagrove, Josephine; Bond, Sarah; Carrasco, Gemma; Delord, Karine; Fisher-Reeves, Lewis; Garcia, David; Gillies, Natasha; Guilford, Tim; Hawkins, Isobel; Jaggers, Paris; Kirk, Christian; Louzao, Maite; Maurice, Lou; McMinn, Miguel; Micol, Thierry; Morford, Joe; Morgan, Greg; Moss, Jason; Riera, Elisa Miquel; Rodriguez, Ana; Siddiqi-Davies, Katrina; Weimerskirch, Henri; Wynn, Russell B.; Padget, Oliver
作者单位：University of Oxford; NERC National Oceanography Centre; University of Southampton; University of Liverpool; Bangor University; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); AZTI; UK Research & Innovation (UKRI); Natural Environment Research Council (NERC); NERC British Geological Survey; Universitat de les Illes Balears; BirdLife International; Royal Society for Protection of Birds
摘要：How individual animals respond to climate change is key to whether populations will persist or go extinct. Yet, few studies investigate how changes in individual behavior underpin these population-level phenomena. Shifts in the distributions of migratory animals can occur through adaptation in migratory behaviors, but there is little understanding of how selection and plasticity contribute to population range shift. Here, we use long-term geolocator tracking of Balearic shearwaters (Puffinus m...
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作者：Munoz-Rojas, Andres R.; Wang, Gang; Benoist, Christophe; Mathis, Diane
作者单位：Harvard University; Harvard Medical School
摘要：Foxp3+CD4+ regulatory T (Treg) cells found within tissues regulate local immunity, inflammation, and homeostasis. Tregs in epididymal visceral adipose tissue (eVAT) are critical regulators of local and systemic inflammation and metabolism. During aging and under obesogenic conditions, eVAT Tregs undergo transcriptional and phenotypic changes and are important for containing inflammation and normalizing metabolic indices. We have employed single - cell RNA sequencing, single - cell Tra and Trb ...
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作者：Ao, Hong; Ruan, Jiaoyang; Martinon-Torres, Maria; Krapp, Mario; Liebrand, Diederik; Dekkers, Mark J.; Caley, Thibaut; Jonell, Tara N.; Zhu, Zongmin; Huang, Chunju; Li, Xinxia; Zhang, Ziyun; Sun, Qiang; Yang, Pingguo; Jiang, Jiali; Li, Xinzhou; Xie, Xiaoxun; Song, Yougui; Qiang, Xiaoke; Zhang, Peng; An, Zhisheng
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Laoshan Laboratory; Institute for Basic Science - Korea (IBS); Pusan National University; Centro Nacional de Investigacion de La Evolucion Humana (CENIEH); University of London; University College London; University of Cambridge; University of Manchester; Utrecht University; Universite de Bordeaux; Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Earth Sciences & Astronomy (INSU); University of Glasgow; China University of Geosciences; Xi'an University of Science & Technology; Shanxi Normal University; Xi'an Jiaotong University; Beijing Normal University
摘要：The relationship between initial Homo sapiens dispersal from Africa to East Asia and the orbitally paced evolution of the Asian summer monsoon (ASM)-currently the largest monsoon system-remains underexplored due to lack of coordinated synthesis of both Asian paleoanthropological and paleoclimatic data. Here, we investigate orbital-scale ASM dynamics during the last 280 thousand years (kyr) and their likely influences on early H. sapiens dispersal to East Asia, through a unique integration of i...
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作者：Dee, Thomas S.
作者单位：Stanford University
摘要：The broad and substantial educational harm caused by the COVID-19 pandemic has motivated large federal, state, and local investments in academic recovery. However, the success of these efforts depends in part on students' regular school attendance. Using state-level data, I show that the rate of chronic absenteeism among US public-school students grew substantially as students returned to in-person instruction. Specifically, between the 2018-2019 and 2021-2022 school years, the share of studen...
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作者：Huang, Yitong; Braun, Rosemary
作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; The Santa Fe Institute
摘要：Abundant epidemiological evidence links circadian rhythms to human health, from heart disease to neurodegeneration. Accurate determination of an individual's circadian phase is critical for precision diagnostics and personalized timing of therapeutic interventions. To date, however, we still lack an assay for physiological time that is accurate, minimally burdensome to the patient, and readily generalizable to new data. Here, we present Time Machine, an algorithm to predict the human circadian...
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作者：Wan, Neng; Hong, Zhouping; Parson, Matthew A. H.; Korfhage, Justin L.; Burke, John E.; Melia, Thomas J.; Reinisch, Karin M.
作者单位：Yale University; University of Victoria; University of British Columbia
摘要：Lipid droplets (LDs) are organelles critical for energy storage and membrane lipid homeostasis, whose number and size are carefully regulated in response to cellular conditions. The molecular mechanisms underlying lipid droplet biogenesis and degradation, however, are not well understood. The Troyer syndrome protein spartin (SPG20) supports LD delivery to autophagosomes for turnover via lipophagy. Here, we characterize spartin as a lipid transfer protein whose transfer ability is required for ...
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作者：Bilodeau, Blair; Jaques, Natasha; Koh, Pang Wei; Kim, Been
作者单位：University of Toronto; University of Washington; University of Washington Seattle; Alphabet Inc.; DeepMind
摘要：Despite a sea of interpretability methods that can produce plausible explanations, the field has also empirically seen many failure cases of such methods. In light of these results, it remains unclear for practitioners how to use these methods and choose between them in a principled way. In this paper, we show that for moderately rich model classes (easily satisfied by neural networks), any feature attribution method that is complete and linear-for example, Integrated Gradients and Shapley Add...
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作者：Wahl, Sebastian C. T.; Travaline, Tara L.; Ramirez, Jessica D.; Choudary, Santosh K.; Agarwal, Sorabh; Walkup, Ward G.; Olsen, Tivoli J.; Brennan, Matthew J.; Verdine, Gregory L.
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作者：Zheng, Miaomiao; Wang, Shuo; Tang, Kexin; Kong, Ruixue; Wang, Xuemeng; Zhou, Jun; Chen, Yan; Wang, Yijie
作者单位：Shandong Normal University
摘要：Poly(ADP- ribose) polymerase 1 (PARP1) plays a crucial role in DNA repair and genomic stability maintenance. However, the regulatory mechanisms governing PARP1 activity, particularly through deubiquitination, remain poorly elucidated. Using a deubiquitinase (DUB) library binding screen, we identified cylindromatosis (CYLD) as a bona fide DUB for PARP1 in breast cancer cells. Mechanistically, CYLD is recruited by PARP1 to DNA lesions upon genotoxic stress, where it cleaves K63- linked polyubiqu...
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作者：Yun, Yaejin; Yoon, Hye - Jin; Jeong, Yejin; Choi, Yuri; Jang, Soonmin; Chung, Ka Young; Lee, Hyung Ho
