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作者：Gervais, Adrian; Le Floc'h, Corentin; Le Voyer, Tom; Bizien, Lucy; Bohlen, Jonathan; Celmeli, Fatih; Al Qureshah, Fahd; Masson, Cecile; Rosein, Jeremi; Chbihi, Marwa; Levy, Romain; Castagnoli, Riccardo; Rothenbuhler, Anya; Jouanguy, Emmanuelle; Zhang, Qian; Zhang, Shen - Ying; Beziat, Vivien; Bustamante, Jacinta; Puela, Anne; Bastard, Paul; Casanova, Jean- Laurent
作者单位：Institut National de la Sante et de la Recherche Medicale (Inserm); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Rockefeller University; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Saint-Louis - APHP; Universite Paris Cite; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP; University of Pavia; Assistance Publique Hopitaux Paris (APHP); Hopital Universitaire Bicetre - APHP; Howard Hughes Medical Institute; Assistance Publique Hopitaux Paris (APHP); Universite Paris Cite; Hopital Universitaire Necker-Enfants Malades - APHP
摘要：Human inborn errors of the type I IFN response pathway and auto-Abs neutralizing IFN-alpha,-beta, and/or-omega can underlie severe viral illnesses. We report a simple assay for the detection of both types of condition. We stimulate whole blood from healthy individuals and patients with either inborn errors of type I IFN immunity or auto-Abs against type I IFNs with glycosylated human IFN-alpha 2,-beta, or-omega. As controls, we add a monoclonal antibody (mAb) blocking the type I IFN receptors ...
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作者：Kamat, Rupini, V; Sharpe, Aaron L.; Pendharkar, Mihir; Hu, Jenny; Tran, Steven J.; Zaborski Jr, Gregory; Hocking, Marisa; Finney, Joe; Watanabe, Kenji; Taniguchi, Takashi; Kastner, Marc A.; Mannix, Andrew J.; Heinz, Tony; Goldhaber-Gordon, David
作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; National Institute for Materials Science; Massachusetts Institute of Technology (MIT)
摘要：The electronic properties of moir & eacute; heterostructures depend sensitively on the relative orientation between layers of the stack. For example, near-magic-angle twisted bilayer graphene (TBG) commonly shows superconductivity, yet a TBG sample with one of the graphene layers rotationally aligned to a hexagonal Boron Nitride (hBN) cladding layer provided experimental observation of orbital ferromagnetism. To create samples with aligned graphene/hBN, researchers often align edges of exfolia...
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作者：Mcnutt, Marcia
作者单位：National Academies of Sciences, Engineering & Medicine
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作者：Rusch, T. Konstantin; Kirk, Nathan; Bronstein, Michael M.; Lemieux, Christiane; Rus, Daniela
作者单位：Massachusetts Institute of Technology (MIT); University of Waterloo; University of Oxford
摘要：Discrepancy is a well-known measure for the irregularity of the distribution of a point set. Point sets with small discrepancy are called low discrepancy and are known to efficiently fill the space in a uniform manner. Low-discrepancy points play a central role in many problems in science and engineering, including numerical integration, computer vision, machine perception, computer graphics, machine learning, and simulation. In this work, we present a machine learning approach to generate a n...
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作者：Mueller, Tim; Montoya, Joseph; Ye, Weike; Lei, Xiangyun; Hung, Linda; Hummelshoj, Jens; Puzon, Michael; Martinez, Daniel; Fajardo, Chris; Abela, Rachel
作者单位：Toyota Motor Corporation
摘要：The electrochemical series is a useful tool in electrochemistry, but its effectiveness in materials chemistry is limited by the fact that the standard electrochemical series is based on a relatively small set of reactions, many of which are measured in aqueous solutions. To address this problem, we have used machine learning to create an electrochemical series for inorganic materials from tens of thousands of entries in the Inorganic Crystal Structure Database. We demonstrate that this series ...
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作者：Yang, Shuihua; Xu, Guoqiang; Zhou, Xue; Li, Jiaxin; Kong, Xianghong; Zhou, Chenglong; Fan, Haiyan; Chen, Jianfeng; Qiu, Cheng - Wei
作者单位：National University of Singapore; Chongqing Technology & Business University; Harbin Institute of Technology; Hong Kong Polytechnic University; National University of Singapore
摘要：Higher- order topological phases in non- Hermitian photonics revolutionize the understanding of wave propagation and modulation, which lead to hierarchical states in open systems. However, intrinsic insulating properties endorsed by the lattice symmetry of photonic crystals fundamentally confine the robust transport only at explicit system boundaries, letting alone the flexible reconfiguration in hierarchical states at arbitrary positions. Here, we report a dynamic topological platform for cre...
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作者：Autour, Alexis; Merten, Christoph A.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; European Molecular Biology Laboratory (EMBL)
摘要：Droplet microfluidics has become a very powerful tool in high- throughput screening, including antibody discovery.Screens are usually carried out by physically sorting droplets hosting cells of the desired phenotype, breaking them, recovering the encapsulated cells, and sequencing the paired antibody light and heavy chain genes at the single- cell level. This series of multiple consecutive manipulation steps of rare screening hits is complex and challenging, resulting in a significant loss of ...
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作者：E., Wenlong; Yi, Wei; Ding, Honghe; Zhu, Junfa; Rosei, Federico; Yang, Xueming; Yu, Miao
作者单位：Chinese Academy of Sciences; Dalian Institute of Chemical Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Harbin Institute of Technology; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University of Trieste; Southern University of Science & Technology; University of Electronic Science & Technology of China
摘要：Free of posttransfer, on- surface synthesis (OSS) of single- atomic- layer nanostructures directly on semiconductors holds considerable potential for next- generation devices. However, due to the high diffusion barrier and abundant defects on semiconductor surfaces, extended and well- defined OSS on semiconductors has major difficulty. Furthermore, given semiconductors' limited thermal catalytic activity, initiating high- barrier reactions remains a significant challenge. Herein, using TiO2(01...
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作者：Li, Weijun; Zhu, Xinfang; Zhang, Mengyue; Yan, Xifeng; Leng, Junchen; Zhou, Yuhong; Liu, Like; Zhang, Dajian; Yuan, Xianzheng; Xue, Dawei; Tian, Huiyu; Ding, Zhaojun
作者单位：Shandong University; Liaocheng University; Shandong Agricultural University; Shandong University; Hangzhou Normal University; Shandong University
摘要：Root exudates are known signaling agents that influence legume root nodulation, but the molecular mechanisms for nonflavonoid molecules remain largely unexplored. The number of soybean root nodules during the initial growth phase shows substantial discrepancies at distinct developmental junctures. Using a combination of metabolomics analyses on root exudates and nodulation experiments, we identify a pivotal role for certain root exudates during the rapid growth phase in promoting nodulation. P...
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作者：Nshimiyimana, Robert; Simard, Melissa; Teder, Tarvi; Rodriguez, Ana R.; Spur, Bernd W.; Haeggstroem, Jesper Z.; Serhan, Charles N.
作者单位：Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard Medical School; Karolinska Institutet; Rowan University
摘要：While the acute inflammatory response to harmful stimuli is protective, unrestrained neutrophil swarming drives collateral tissue damage and inflammation. Biosynthesized from omega- 3 essential polyunsaturated fatty acids, resolvins are a family of signaling molecules produced by immune cells within the resolution phase to orchestrate return to homeostasis. Understanding the mechanisms that govern biosynthesis of these potent molecules gives insight into stimulating endogenous resolution and o...
