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作者：Li, Feng; Mi, Yixin; Chen, Ronn Zhi Ning; Liu, Wei; Wu, Ji; Hou, Deyin; Yang, Min; Zhang, Sui
作者单位：National University of Singapore; Chinese Academy of Sciences; National University of Singapore; Southeast University - China; Purple Mountain Laboratories
摘要：Integrating reactive radicals into membranes that resemble biological membranes has always been a pursuit for simultaneous organics degradation and water filtration. In this research, we discovered that a radical polymer (RP) that can directly trigger the oxidative degradation of sulfamethozaxole (SMX). Mechanistic studies by experiment and density functional theory simulations revealed that peroxyl radicals are the reactive species, and the radicals could be regenerated in the presence of O-2...
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作者：Zhao, Gan; Xue, Lulu; Geisler, Hannah C.; Xu, Junchao; Li, Xinyuan; Mitchell, Michael J.; Vaughan, Andrew E.
作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania
摘要：Macrophages are integral components of the innate immune system, playing a dual role in host defense during infection and pathophysiological states. Macrophages contribute to immune responses and aid in combatting various infections, yet their production of abundant proinflammatory cytokines can lead to uncontrolled inflammation and worsened tissue damage. Therefore, reducing macrophage- derived proinflammatory cytokine release represents a promising approach for treating various acute and chr...
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作者：Hu, Shi-Qi; Chen, Da-Qiang; Du, Lan-Lin; Meng, Sheng
作者单位：Chinese Academy of Sciences; Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Songshan Lake Materials Laboratory
摘要：High pressure has triggered various novel states/properties in condensed matter, as the most representative and dramatic example being near- room- temperature superconductivity in highly pressured hydrides (-200 GPa). However, the mechanism of superconductivity is not confirmed, due to the lacking of effective approach to probe the electronic band structure under such high pressures. Here, we theoretically propose that the band structure and electron- phonon coupling (EPC) of high- pressure qu...
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作者：Huang, Qiu-Shi; Zhang, Yang; Liu, Peng Fei; Yang, Hua Gui; Zhang, Xie; Wei, Su-Huai
作者单位：Chinese Academy of Engineering Physics; Beijing Computational Science Research Center (CSRC); East China University of Science & Technology; Northwestern Polytechnical University
摘要：As a prototypical photocatalyst, TiO2 has been extensively studied. An interesting yet enhances the overpotential of the hydrogen evolution reaction. Also, the corresponding band alignment at the interface leads to efficient separation of electrons and holes. The interfacial confinement additionally creates a wide distribution of the band gap in the vicinity of the interface, which in turn improves optical absorption. These factors all contribute to the enhanced photocatalytic efficiency in P2...
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作者：Pham, An T.; Mani, Madhav; Wang, Xiaozhong; Vafabakhsh, Reza
作者单位：Northwestern University; Northwestern University; Northwestern University
摘要：During cell division, precise and regulated distribution of cellular material between daughter cells is a critical step and is governed by complex biochemical and biophysical mechanisms. To achieve this, membraneless organelles and condensates often require complete disassembly during mitosis. The biophysical principles governing the disassembly of condensates remain poorly understood. Here, we used a physical biology approach to study how physical and material properties of the nucleolus, a p...
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作者：Mout, Rubul; Bretherton, Ross C.; Decarreau, Justin; Lee, Sangmin; Gregorio, Nicole; Edman, Natasha I.; Ahlrichs, Maggie; Hsia, Yang; Sahtoe, Danny D.; Ueda, George; Sharmal, Alee; Schulman, Rebecca; Deforest, Cole A.; Bakera, David
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Harvard University; Harvard University Medical Affiliates; Boston Children's Hospital; Harvard Medical School; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Howard Hughes Medical Institute; Northeastern University; Johns Hopkins University; Johns Hopkins University
摘要：Relating the macroscopic properties of protein - based materials to their underlying component microstructure is an outstanding challenge. Here, we exploit computational design to specify the size, flexibility, and valency of de novo protein building blocks, as well as the interaction dynamics between them, to investigate how molecular parameters govern the macroscopic viscoelasticity of the resultant protein hydrogels. We construct gel systems from pairs of symmetric protein homo- oligomers, ...
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作者：Pun, Michael N.; Ivanov, Andrew; Bellamy, Quinn; Montague, Zachary; Lamont, Colin; Bradley, Philip; Otwinowski, Jakub; Nourmohammad, Armita
作者单位：University of Washington; University of Washington Seattle; Max Planck Society; Fred Hutchinson Cancer Center; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Proteins play a central role in biology from immune recognition to brain activity. While major advances in machine learning have improved our ability to predict protein structure from sequence, determining protein function from its sequence or structure remains a major challenge. Here, we introduce holographic convolutional neural network (H-CNN) for proteins, which is a physically motivated machine learning approach to model amino acid preferences in protein structures. H-CNN reflects physica...
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作者：Bergstrom, Carl T.; Ruxton, Graeme D.
作者单位：University of Washington; University of Washington Seattle; University of St Andrews
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作者：Hwang, Yen-Ting; Xie, Shang Ping; Chen, Po-Ju; Tseng, Hung-Yi; Deser, Clara
作者单位：National Taiwan University; University of California System; University of California San Diego; Scripps Institution of Oceanography; George Mason University; National Center Atmospheric Research (NCAR) - USA
摘要：The discrepancy between the observed lack of surface warming in the eastern equatorial Pacific and climate model projections of an El Nino- like warming pattern confronts the climate research community. While anthropogenic aerosols have been suggested as a cause, the prolonged cooling trend over the equatorial Pacific appears in conflict with Northern Hemisphere aerosol emission reduction since the 1980s. Here, using CESM, we show that the superposition of fast and slow responses to aerosol em...
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作者：Ma, Yongshuo; Shang, Yi; Stephanopoulos, Gregory
作者单位：Massachusetts Institute of Technology (MIT); Chinese Academy of Agricultural Sciences; Yunnan Normal University; Yunnan Normal University
摘要：Constructing efficient cell factories for product synthesis is frequently hampered by competing pathways and/or insufficient precursor supply. This is particularly evident in the case of triterpenoid biosynthesis in Yarrowia lipolytica, where squalene biosynthesis is tightly coupled to cytosolic biosynthesis of sterols essential for cell viability. Here, we addressed this problem by reconstructing the complete squalene biosynthetic pathway, starting from acetyl-CoA, in the peroxisome, thus har...
