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作者：Guo, Wei; Wenz, Leonie; Auffhammer, Maximilian
作者单位：Centro Euro-Mediterraneo sui Cambiamenti Climatici (CMCC); Potsdam Institut fur Klimafolgenforschung; University of California System; University of California Berkeley; National Bureau of Economic Research
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作者：Kitamura, Rie Asada; Hummel, Devynn; Ustione, Alessandro; Piston, David W.; Urano, Fumihiko
作者单位：Washington University (WUSTL); Washington University (WUSTL); Washington University (WUSTL)
摘要：Mesencephalic astrocyte- derived neurotrophic factor (MANF) is an endoplasmic reticulum (ER)- resident secretory protein that reduces inflammation and promotes proliferation in pancreatic beta cells. Numerous studies have highlighted the potential of MANF as a therapeutic agent for diabetes mellitus (DM), making it essential to understand the mechanisms underlying MANF's functions. In our previous search for a molecule that mediates MANF signaling, we identified Neuroplastin (NPTN) as a bindin...
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作者：Lewis, Jacob A.; Nemke, Brett; Lu, Yan; Sather, Nicholas A.; Mcclendon, Mark T.; Mullen, Michael; Yuan, Shelby C.; Ravuri, Sudheer K.; Bleedorn, Jason A.; Philippon, Marc J.; Huard, Johnny; Markel, Mark D.; Stupp, Samuel I.
作者单位：Northwestern University; Northwestern University; University of Wisconsin System; University of Wisconsin Madison; Steadman Philippon Research Institute; University of Wisconsin System; University of Wisconsin Madison; Northwestern University; Northwestern University; Northwestern University
摘要：Regeneration of hyaline cartilage in human- sized joints remains a clinical challenge, and it is a critical unmet need that would contribute to longer healthspans. Injectable scaffolds for cartilage repair that integrate both bioactivity and sufficiently robust physical properties to withstand joint stresses offer a promising strategy. We report here on a hybrid biomaterial that combines a bioactive peptide amphiphile supramolecular polymer that specifically binds the chondrogenic cytokine tra...
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作者：Liu, Ji; Zheng, Qizhen; Yao, Rui; Wang, Ming
作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS
摘要：Protein therapeutics play a critical role in treating a large variety of diseases, ranging from infections to genetic disorders. However, their delivery to target tissues beyond the liver, such as the lungs, remains a great challenge. Here, we report a universally applicable strategy for lung- targeted protein delivery by engineering Lung- Specific Supramolecular Nanoparticles (LSNPs). These nanoparticles are designed through the hierarchical self- assembly of metal- organic polyhedra (MOP), f...
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作者：Greenberg, Miriam; Angelo, Hillary; Losada, Elena; Wilmers, Christopher C.
作者单位：University of California System; University of California Santa Cruz; University of California System; University of California Santa Cruz
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作者：Kern, Vanessa R.; Carlson, Andreas
作者单位：University of Oslo
摘要：Drop-fiber interactions are fundamental to the operation of technologies such as atmospheric fog capture, oil filtration, refrigeration, and dehumidification. We demonstrate that by twisting together two fibers, a sliding drop's flow path can be controlled by tuning the ratio between its size and the twist wavelength. We find both experimentally and numerically that twisted fiber systems are able to asymmetrically stabilize drops, both enhancing drop transport speeds and creating a rich array ...
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作者：Farahvash, Ardavan; Willard, Adam P.
作者单位：Massachusetts Institute of Technology (MIT)
摘要：In this manuscript, we provide a general theory for how surface phonons couple to molecular adsorbates. Our theory maps the extended dynamics of a surface's atomic vibrational motions to a generalized Langevin equation, and by doing so captures these dynamics in a single quantity: the non-Markovian friction. The different frequency components of this friction are the phonon modes of the surface slab weighted by their coupling to the adsorbate degrees of freedom. Using this formalism, we demons...
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作者：Gu, Bowen; Le, Gia-Han; Herrera, Sebastian; Blair, Steven J.; Meissner, Torsten B.; Strominger, Jack L.
作者单位：Harvard University; Harvard University; Harvard University Medical Affiliates; Beth Israel Deaconess Medical Center; Harvard University; Harvard Medical School
摘要：The distinct human leukocyte antigen (HLA) class I expression pattern of human extravillous trophoblasts (EVT) endows them with unique tolerogenic properties that enable successful pregnancy. Nevertheless, how this process is elaborately regulated remains elusive. Previously, E74 like ETS transcription factor 3 (ELF3) was identified to govern high- level HLA- C expression in EVT. In the present study, ELF3 is found to bind to the enhancer region of two adjacent NOD- like receptor (NLR) genes, ...
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作者：Itoh, Masayuki; Piot, Laura; Mony, Laetitia; Paoletti, Pierre; Yuzaki, Michisuke
作者单位：Keio University; Universite PSL; Ecole Normale Superieure (ENS); Centre National de la Recherche Scientifique (CNRS); Institut National de la Sante et de la Recherche Medicale (Inserm)
摘要：Delta receptors (GluD1 and GluD2), members of the large ionotropic glutamate receptor (iGluR) family, play a central role in numerous neurodevelopmental and psychiatric disorders. The amino- terminal domain (ATD) of GluD orchestrates synapse formation and maturation processes through its interaction with the Cbln family of synaptic organizers and neurexin (Nrxn). The transsynaptic triad of Nrxn-Cbln-GluD also serves as a potent regulator of synaptic plasticity, at both excitatory and inhibitor...
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作者：Touchon, Justin C.; Mcmillan, W. Owen; Ibanez, Roberto; Lessios, Harilaos A.
作者单位：Vassar College; Smithsonian Institution; Smithsonian Tropical Research Institute
摘要：Among vertebrates, nearly all oviparous animals are considered to have either obligate aquatic or terrestrial oviposition, with eggs that are specialized for developing in those environments. The terrestrial environment has considerably more oxygen but is dry and thus presents both opportunities and challenges for developing embryos, particularly those adapted for aquatic development. Here, we present evidence from field experiments examining egg- laying behavior, egg size, and egg jelly funct...
