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作者：Estien, Cesar O.; Fidino, Mason; Wilkinson, Christine E.; Morello-Frosch, Rachel; Schell, Christopher J.
作者单位：University of California System; University of California Berkeley; California Academy of Sciences; University of California System; University of California Berkeley
摘要：Legacy effects describe the persistent, long - term impacts on an ecosystem following the removal of an abiotic or biotic feature. Redlining, a policy that codified racial segregation and disinvestment in minoritized neighborhoods, has produced legacy effects with profound impacts on urban ecosystem structure and health. These legacies have detrimentally impacted public health outcomes, socioeconomic stability, and environmental health. However, the collateral impacts of redlining on wildlife ...
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作者：Kumari, Poonam; Tarighi, Shahriar; Fuchshuber, Eva; Li, Luhan; Fernandez-Duran, Irene; Wang, Meilin; Ayoson, Joshua; Castello-Garcia, Jose Manuel; Gamez-Garcia, Andres; Espinosa-Alcantud, Maria; Sreenivasan, Krishnamoorthy; Guenther, Stefan; Olivella, Mireia; Savai, Rajkumar; Yue, Shijing; Vaquero, Alejandro; Braun, Thomas; Ianni, Alessandro
作者单位：Max Planck Society; Nankai University; Institut de Recerca Contra la Leucemia Josep Carreras (IJC); Max Planck Society; Universitat de Vic - Universitat Central de Catalunya (UVic-UCC); Justus Liebig University Giessen
摘要：Sirtuin 7 (SIRT7) is a member of the mammalian family of nicotinamide adenine dinucleotide (NAD + ) - dependent histone/protein deacetylases, known as sirtuins. It acts as a potent oncogene in numerous malignancies, but the molecular mechanisms employed by SIRT7 to sustain lung cancer progression remain largely uncharacterized. We demonstrate that SIRT7 exerts oncogenic functions in lung cancer cells by destabilizing the tumor suppressor alternative reading frame (ARF). SIRT7 directly interact...
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作者：Lee, Soo Ahn; Lee, Jae-Joong; Han, Jisoo; Choi, Myunghwan; Wager, Tor D.; Woo, Choong-Wan
作者单位：Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Korea Brain Research Institute (KBRI); Seoul National University (SNU); Dartmouth College
摘要：Pleasure and pain are two fundamental, intertwined aspects of human emotions. Pleasurable sensations can reduce subjective feelings of pain and vice versa, and we often perceive the termination of pain as pleasant and the absence of pleasure as unpleasant. This implies the existence of brain systems that integrate them into modality- general representations of affective experiences. Here, we examined representations of affective valence and intensity in an functional MRI (fMRI) study ( n = 58)...
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作者：Huang, Yuqi; Luan, Shenghua; Wu, Baizhou; Li, Yugang; Wu, Junhui; Chen, Wenfeng; Hertwig, Ralph; Weber, Elke
作者单位：Chinese Academy of Sciences; Institute of Psychology, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Renmin University of China; Max Planck Society
摘要：Impulsivity is a personality construct frequently employed to explain and predict important human behaviors. Major inconsistencies in its definition and measurement, however, have led some researchers to call for an outright rejection of impulsivity as a psychological construct. We address this highly unsatisfactory state with a large - scale, preregistered study ( N = 1,676) in which each participant completed 48 measures of impulsivity derived from 10 self - report scales and 10 behavioral t...
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作者：Yan, Xu; Shi, Gehui; Sun, Miao; Shan, Shengchen; Chen, Runzhou; Li, Runhui; Wu, Songlin; Zhou, Zheng; Li, Yuhan; Liu, Zhenhua; Hu, Yonghong; Liu, Zhongjian; Soltis, Pamela S.; Zhang, Jiaqi; Soltis, Douglas E.; Ning, Guogui; Bao, Manzhu
作者单位：Huazhong Agricultural University; State University System of Florida; University of Florida; Chinese Academy of Sciences; Fujian Agriculture & Forestry University; State University System of Florida; University of Florida; State University System of Florida; University of Florida; State University System of Florida; University of Florida
摘要：Whole - genome duplication (WGD; i.e., polyploidy) and chromosomal rearrangement (i.e., genome shuffling) significantly influence genome structure and organization. Many polyploids show extensive genome shuffling relative to their pre - WGD ancestors. No r eference genome is currently available for Platanaceae (Proteales), one of the sister groups to the core eudicots. Moreover, Platanus x acerifolia (London planetree; Platanaceae) is a widely used street tree. Given the pivotal phylogenetic p...
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作者：Lee, James; Oldham, Michael L.; Manon, Victor; Chen, Jue
作者单位：Rockefeller University
摘要：Our ability to fight pathogens relies on major histocompatibility complex class I (MHC - I) molecules presenting diverse antigens on the surface of diseased cells. The transporter associated with antigen processing (TAP) transports nearly the entire repertoire of antigenic peptides into the endoplasmic reticulum for MHC - I loading. How TAP transports peptides specific for MHC - I is unclear. In this study, we used cryo - EM to determine a series of structures of human TAP, both in the absence...
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作者：Ranganathan, Meghana; Minchew, Brent
作者单位：Massachusetts Institute of Technology (MIT); University System of Georgia; Georgia Institute of Technology
摘要：Glacier flow modulates sea level and is governed largely by the viscous deformation ice. Multiple molecular -scale mechanisms facilitate viscous deformation, but it remains unclear how each contributes to glacier -scale deformation. Here, we present a model ice deformation that bridges laboratory and glacier scales, unifies existing estimates the viscous parameters, and provides a framework for estimating the parameters from observations and incorporating flow laws derived from laboratory obse...
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作者：Fresneau, Nolwenn; Pipoly, Ivett; Gigler, Dora; Kosztolanyi, Andrzs; Szekely, Tamzs; Liker, Andrzs
作者单位：University of Pannonia; University of Pannonia; University of Veterinary Medicine Budapest; University of Bath; University of Debrecen; University of Debrecen
摘要：Males and females often have different roles in reproduction, although the origin of these differences has remained controversial. Explaining the enigmatic reversed sex roles where males sacrifice their mating potential and provide full parental care is a particularly long - standing challenge in evolutionary biology. While most studies focused on ecological factors as the drivers of sex roles, recent research highlights the significance of social factors such as the adult sex ratio. To disent...
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作者：Nechushtai, Rachel; Rowland, Linda; Karmi, Ola; Marjault, Henri- Baptiste; Nguyen, Thi Thao; Mittal, Shubham; Ahmed, Raheel S.; Grant, Deana; Manrique-Acevedo, Camila; Morcos, Faruck; Onuchic, Jose N.; Mittler, Ron
作者单位：Hebrew University of Jerusalem; Hebrew University of Jerusalem; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Texas System; University of Texas Dallas; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; University of Missouri System; University of Missouri Columbia; US Department of Veterans Affairs; Veterans Health Administration (VHA); Harry S. Truman Memorial Veterans' Hospital; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; University of Texas System; University of Texas Dallas; Rice University; Rice University; Rice University; Rice University
摘要：Mitochondria play a central role in muscle metabolism and function. A unique family of iron-sulfur proteins, termed CDGSH Iron Sulfur Domain - containing (CISD/NEET) proteins, support mitochondrial function in skeletal muscles. The abundance of these proteins declines during aging leading to muscle degeneration. Although the function of the outer mitochondrial CISD/NEET proteins, CISD1/mitoNEET and CISD2/NAF - 1, has been defined in skeletal muscle cells, the role of the inner mitochondrial CI...
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作者：Echenique, Federico; He, Kevin
作者单位：University of California System; University of California Berkeley; University of Pennsylvania
摘要：We show that adding noise before publishing data effectively screens p -hacked findings: spurious explanations produced by fitting many statistical models (data mining). Noise creates baits that affect two types of researchers differently. Uninformed p -hackers, who are fully ignorant of the true mechanism and engage in data mining, often fall for baits. Informed researchers, who start with an ex ante hypothesis, are minimally affected. We show that as the number of observations grows large, d...
