Brain representations of affective valence and intensity in sustained pleasure and pain

• 成果类型: Article
• 署名作者: Lee, Soo Ahn; Lee, Jae-Joong; Han, Jisoo; Choi, Myunghwan; Wager, Tor D.; Woo, Choong-Wan
• 署名单位: Institute for Basic Science - Korea (IBS); Sungkyunkwan University (SKKU); Sungkyunkwan University (SKKU); Korea Brain Research Institute (KBRI); Seoul National University (SNU); Dartmouth College
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-12588
• DOI: 10.1073/pnas.2310433121
• 发表日期: 2024-06-18
• 关键词: stimuli; emotion; SYSTEM; cortex; metaanalysis; SALIENCE; network; context

摘要

Pleasure and pain are two fundamental, intertwined aspects of human emotions. Pleasurable sensations can reduce subjective feelings of pain and vice versa, and we often perceive the termination of pain as pleasant and the absence of pleasure as unpleasant. This implies the existence of brain systems that integrate them into modality- general representations of affective experiences. Here, we examined representations of affective valence and intensity in an functional MRI (fMRI) study ( n = 58) of sustained pleasure and pain. We found that the distinct subpopulations of voxels within the ventromedial and lateral prefrontal cortices, the orbitofrontal cortex, the anterior insula, and the amygdala were involved in decoding affective valence versus intensity. Affective valence and intensity predictive models showed significant decoding performance in an independent test dataset ( n = 62). These models were differentially connected to distinct large- scale brain networks-the intensity model to the ventral attention network and the valence model to the limbic and default mode networks. Overall, this study identified the brain representations of affective valence and intensity across pleasure and pain, promoting a systems- level understanding of human affective experiences.