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作者：Ma, Bin; Zhang, You; Fan, Yanfei; Zhang, Lin; Li, Xiaoyuan; Zhang, Qi-Qi; Shu, Qingyao; Huang, Jirong; Chen, Genyun; Li, Qun; Gao, Qifei; Zhu, Xin-Guang; He, Zuhua; Wang, Peng
作者单位：Chinese Academy of Sciences; Center for Excellence in Molecular Plant Sciences, CAS
摘要：Low phosphate (Pi) availability decreases photosynthesis, with phosphate limitation of photosynthesis occurring particularly during grain filling of cereal crops; however, effective genetic solutions remain to be established. We previously discovered that rice phosphate transporter OsPHO1;2 controls seed (sink) development through Pi reallocation during grain filling. Here, we find that OsPHO1;2 regulates Pi homeostasis and thus photosynthesis in leaves (source). Loss- of- function of OsPHO1;2...
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作者：Becchi, Matteo; Fantolino, Federico; Pavan, Giovanni M.
作者单位：Polytechnic University of Turin
摘要：Complex systems are typically characterized by intricate internal dynamics that are often hard to elucidate. Ideally, this requires methods that allow to detect and classify in an unsupervised way the microscopic dynamical events occurring in the system. However, decoupling statistically relevant fluctuations from the internal noise remains most often nontrivial. Here, we describe Onion Clustering: a simple, iterative unsupervised clustering method that efficiently detects and classifies stat...
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作者：Zhang, Wei; Shi, Ke; Hsueh, Fu - Chun; Mendoza, Alise; Ye, Gang; Huang, Linfen; Perlman, Stanley; Aihara, Hideki; Li, Fang
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Iowa
摘要：The animal origin of SARS-CoV-2 remains elusive, lacking a plausible evolutionary narrative that may account for its emergence. Its spike protein resembles certain segments of BANAL- 236 and RaTG13, two bat coronaviruses considered possible progenitors of SARS- CoV-2. Additionally, its spike contains a furin motif, a common feature of rodent coronaviruses. To explore the possible involvement of rodents in the emergence of SARS-CoV-2 spike, we examined the crystal structures of the spike recept...
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作者：Che, Shun; Guan, Xun; Rodrigues, Roselyn; Yu, Yaochun; Xie, Yongchao; Liu, Chong; Men, Yujie
作者单位：University of California System; University of California Riverside; University of Illinois System; University of Illinois Urbana-Champaign; University of California System; University of California Los Angeles; University of California System; University of California Los Angeles; Stanford University; Gonzaga University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG)
摘要：Per- and polyfluoroalkyl substances (PFAS), particularly the perfluorinated ones, are recalcitrant to biodegradation. By integrating an enrichment culture of reductive defluorination with biocompatible electrodes for the electrochemical process, a deeper defluorination of a C6- perfluorinated unsaturated PFAS was achieved compared to the biological or electrochemical system alone. Two synergies in the bioelectrochemical system were identified: i) The in- series microbial- electrochemical deflu...
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作者：Davies, Liam Courtney-; Fiorentini, Marco; Dalstra, Hilke; Hagemann, Steffen; Ramanaidou, Erick; Danisik, Martin; Evans, Noreen J.; Rankenburg, Kai; Mcinnes, Brent I. A.
作者单位：Curtin University; University of Western Australia; Rio Tinto; Commonwealth Scientific & Industrial Research Organisation (CSIRO); CSIRO Mineral Resources
摘要：Banded iron formations (BIFs) archive the relationship between Earth's lithosphere, hydrosphere, and atmosphere through time. However, constraints on the origin of Earth's largest ore deposits, hosted by BIFs, are limited by the absence of direct geochronology. Without this temporal context, genetic models cannot be correlated with tectono-thermal and atmospheric drivers responsible for BIF upgrading through time. Utilizing in situ iron oxide U-Pb geochronology, we provide a direct timeline of...
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作者：Delecroix, Clara; van Nes, Egbert H.; Scheffer, Marten; van de Leemput, Ingrid A.
作者单位：Wageningen University & Research
摘要：The possibility to anticipate critical transitions through detecting loss of resilience has attracted attention in many fields. Resilience indicators rely on the mathematical concept of critical slowing down, which means that a system recovers more slowly from external perturbations when it gets closer to tipping point. This decrease in recovery rate can be reflected in rising autocorrelation and variance in data. To test whether resilience is changing, resilience indicators are often calculat...
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作者：Singh, Abhishek; Chakraborty, Janardan; Pal, Sumit; Das, Dibyendu
作者单位：Indian Institute of Science Education & Research (IISER) - Kolkata; Indian Institute of Science Education & Research (IISER) - Kolkata
摘要：The evolution of complex chemical inventory from Darwin's nutrient- rich warm pond necessitated rudimentary yet efficient catalytic folds. Short peptides and their self- organized microstructures, ranging from spherical colloids to amyloidogenic aggregates might have played a crucial role in the emergence of contemporary catalytic entities. However, the question of how short peptide fragments had functions akin to contemporary complex enzymes to catalyze cleavage and formation of highly stable...
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作者：Chakrabarti, Brato; Rachh, Manas; Shvartsman, Stanislav Y.; Shelley, Michael J.
作者单位：Simons Foundation; Flatiron Institute; Tata Institute of Fundamental Research (TIFR); International Centre for Theoretical Sciences, Bengaluru; Simons Foundation; Flatiron Institute; Princeton University; Princeton University; New York University
摘要：Large cells often rely on cytoplasmic flows for intracellular transport, maintaining homeostasis, and positioning cellular components. Understanding the mechanisms of these flows is essential for gaining insights into cell function, developmental processes, and evolutionary adaptability. Here, we focus on a class of self-organized cytoplasmic stirring mechanisms that result from fluid-structure interactions between cytoskeletal elements at the cell cortex. Drawing inspiration from streaming fl...
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作者：Sgroi, Mara; Hoey, David; Jimenez, Karina Medina; Bowden, Sarah L.; Hope, Matthew; Wallington, Emma J.; Schornack, Sebastian; Bravo, Armando; Paszkowski, Uta
作者单位：University of Cambridge; University of Cambridge; Donald Danforth Plant Science Center
摘要：The mutualistic arbuscular mycorrhizal (AM) symbiosis arose in land plants more than 450 million years ago and is still widely found in all major land plant lineages. Despite its broad taxonomic distribution, little is known about the molecular components underpinning symbiosis outside of flowering plants. The ARBUSCULAR RECEPTOR- LIKE KINASE (ARK) is required for sustaining AM symbiosis in distantly related angiosperms. Here, we demonstrate that ARK has an equivalent role in symbiosis mainten...
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作者：Alasady, Milad J.; Koeva, Martina; Takagishi, Seesha R.; Segal, Dmitri; Amici, David R.; Smith, Roger S.; Ansel, Daniel J.; Lindquist, Susan; Whitesell, Luke; Bartom, Elizabeth T.; Taipale, Mikko; Mendillo, Marc L.
作者单位：Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Ann & Robert H. Lurie Children's Hospital of Chicago; Robert H. Lurie Comprehensive Cancer Center; Massachusetts Institute of Technology (MIT); Whitehead Institute; Massachusetts Institute of Technology (MIT); Howard Hughes Medical Institute; University of Toronto
摘要：Heat Shock Factor 1 (HSF1) is best known as the master transcriptional regulator of the heat- shock response (HSR), a conserved adaptive mechanism critical for protein homeostasis (proteostasis). Combining a genome-wide- wide RNAi library with an HSR reporter, we identified Jumonji domain-- containing protein 6 (JMJD6) as an essential mediator of HSF1 activity. In follow- up studies, we found that JMJD6 is itself a noncanonical transcriptional target of HSF1 which acts as a critical regulator ...
