2024

最新文章

• Nuclear compensatory evolution driven by mito-nuclear incompatibilities AI翻译
  作者：Princepe, Debora; de Aguiar, Marcus A. M.
  作者单位：Universidade Estadual de Campinas; Abdus Salam International Centre for Theoretical Physics (ICTP)
  摘要：Mitochondrial function relies on the coordinated expression of mitochondrial and nuclear genes, exhibiting remarkable resilience despite high mitochondrial mutation rates. The nuclear compensation mechanism suggests deleterious mitochondrial alleles drive compensatory nuclear mutations to preserve mito-nuclear compatibility. However, prevalence and factors conditioning this phenomenon remain debated due to its conflicting evidence. Here, we investigate how mito-nuclear incompatibilities impact...
• Toward a metabolic theory of catchments: Scaling of water and carbon fluxes with size AI翻译
  作者：Bassani, Francesca; Fatichi, Simone; Rinaldo, Andrea; Bonetti, Sara
  作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; National University of Singapore; Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; University of Padua
  摘要：Allometric scaling relations are widely used to link biological processes to body size in nature. Several studies have shown that such scaling laws hold also for natural ecosystems, including individual trees and forests, riverine metabolism, and river network organization. However, the derivation of scaling laws for catchment-scale water and carbon fluxes has not been achieved so far. Here, we focus on scaling relations of catchment green metabolism, defined as the set of ecohydrological and ...
• Synaptic weight dynamics underlying memory consolidation: Implications for learning rules, circuit organization, and circuit function AI翻译
  作者：Bhasin, Brandon J.; Raymond, Jennifer L.; Goldman, Mark S.
  作者单位：Stanford University; University of California System; University of California Davis; Stanford University; University of California System; University of California Davis; University of California System; University of California Davis
  摘要：Systems consolidation is a common feature of learning and memory systems, in which a long-term memory initially stored in one brain region becomes persistently stored in another region. We studied the dynamics of systems consolidation in simple circuit architectures with two sites of plasticity, one in an early-learning and one in a late-learning brain area. We show that the synaptic dynamics of the circuit during consolidation of an analog memory can be understood as a temporal integration pr...
• Toward a CRISPR- based mouse model of Vhl- deficient clear cell kidney cancer: Initial experience and lessons learned AI翻译
  作者：Stransky, Laura A.; Gao, Wenhua; Schmidt, Laura S.; Bi, Kevin; Ricketts, Christopher J.; Ramesh, Vijyendra; James, Amy; Difilippantonio, Simone; Ileva, Lilia; Kalen, Joseph D.; Karim, Baktiar; Jeon, Albert; Morgan, Tamara; Warner, Andrew C.; Turan, Sevilay; Unite, Joanne; Tran, Bao; Choudhari, Sulbha; Zhao, Yongmei; Linn, Douglas E.; Yun, Changhong; Dhandapani, Sripriya; Parab, Vaishali; Pinheiro, Elaine M.; Morris, Nicole; He, Lixia; Vigeant, Sean M.; Pignon, Jean- Christophe; Ivins, Maura Sticco --; Signoretti, Sabina; Allen, Eliezer M. Van; Linehan, W. Marston; Kaelin, William G.
  作者单位：Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; Merck & Company; Merck & Company USA; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Howard Hughes Medical Institute
  摘要：CRISPR is revolutionizing the ability to do somatic gene editing in mice for the purpose of creating new cancer models. Inactivation of the VHL tumor suppressor gene is the signature initiating event in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). Such tumors are usually driven by the excessive HIF2 activity that arises when the VHL gene product, pVHL, is defective. Given the pressing need for a robust immunocompetent mouse model of human ccRCC, we directly i...
• Jane I. Guyer (1943-2024): A singular student of economic life and enthusiastic supporter of the careers of others AI翻译
  作者：Schoenbrun, David
  作者单位：Northwestern University
• Proteomic and phosphoproteomic landscape of localized prostate cancer unveils distinct molecular subtypes and insights into precision therapeutics AI翻译
  作者：Wang, Zengming; Yu, Haolan; Bao, Wei; Qu, Min; Wang, Yan; Zhang, Liandong; Liu, Xubing; Liu, Chen; He, Miaoxia; Li, Jing; Dong, Zhenyang; Zhang, Yun; Yang, Bo; Hou, Jianguo; Xu, Chuanliang; Wang, Linhui; Li, Xin; Gao, Xu; Yang, Chenghua
  作者单位：Naval Medical University; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Shanghai Institute of Nutrition & Health, CAS; University of Chinese Academy of Sciences, CAS; Naval Medical University; Shenzhen Bay Laboratory; Shanghai Jiao Tong University
  摘要：Building upon our previous investigation of genomic, epigenomic, and transcriptomic profiles of prostate cancer in China, we conducted a comprehensive analysis of proteomic and phosphoproteomic profiles of 82 tumor tissues and matched adjacent normal tissues from 41 Chinese patients with localized prostate cancer. We identified three distinct proteomic subtypes with significant difference in both molecular features and clinical prognosis. Notably, these proteomic subtypes exhibited a parallel ...
• Generating interstitial water within the persisting tetrahedral H-bond network explains density increase upon compressing liquid water AI翻译
  作者：Forster, Mirko; Ukoji, Nnanna; Sahle, Christoph J.; Niskanen, Johannes; Sakrowski, Robin; Surmeier, Goran; Weis, Christopher; Irifune, Tetsuo; Imoto, Sho; Yavas, Hasan; Huotari, Simo; Marx, Dominik; Sternemann, Christian; Tse, John S.
  作者单位：Dortmund University of Technology; University of Saskatchewan; European Synchrotron Radiation Facility (ESRF); University of Turku; Ehime University; Ruhr University Bochum; Helmholtz Association; Deutsches Elektronen-Synchrotron (DESY); Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; University of Helsinki
  摘要：Despite its ubiquitous nature, the atomic structure of water in its liquid state is still controversially debated. We use a combination of X-ray Raman scattering spectroscopy in conjunction with ab initio and path integral molecular dynamics simulations to study the local atomic and electronic structure of water under high pressure conditions. Systematically increasing fingerprints of non-hydrogen-bonded H2O molecules in the first hydration shell are identified in the experimental and computat...
• The androgen receptor in mesenchymal progenitors regulates skeletal muscle mass via Igf1 expression in male mice AI翻译
  作者：Sakai, Hiroshi; Uno, Hideaki; Yamakawa, Harumi; Tanaka, Kaori; Ikedo, Aoi; Uezumi, Akiyoshi; Ohkawa, Yasuyuki; Imai, Yuuki
  作者单位：Ehime University; Ehime University; Kyushu University; Kyushu University
  摘要：Androgens exert their effects primarily by binding to the androgen receptor (AR), ligand- dependent nuclear receptor. While androgens have anabolic effects on skeletal muscle, previous studies reported that AR functions in myofibers to regulate skeletal muscle quality, rather than skeletal muscle mass. Therefore, the anabolic effects of androgens are exerted via nonmyofiber cells. In this context, the cellular and molecular mechanisms of AR in mesenchymal progenitors, which play a crucial role...
• Hierarchical communities in the larval Drosophila connectome: Links to cellular annotations and network topology AI翻译
  作者：Betzel, Richard; Puxeddu, Maria Grazia; Seguin, Caio
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; University of Minnesota System; University of Minnesota Twin Cities
  摘要：One of the longstanding aims of network neuroscience is to link a connectome's topological properties-i.e., features defined from connectivity alone-with an organism's neurobiology. One approach for doing so is to compare connectome properties with annotational maps. This type of analysis is popular at the meso-/macroscale, but is less common at the nano-scale, owing to a paucity of neuron-level connectome data. However, recent methodological advances have made possible the reconstruction of w...
• Familial Parkinson's point mutation abolishes multiple system atrophy prion replication (vol 115, pg 409, 2017) AI翻译
  作者：Woerman, Amanda L.; Kazmi, Sabeen A.; Patel, Smita; Aoyagi, Atsushi; Oehler, Abby; Widjaja, Kartika; Mordes, Daniel A.; Olson, Steven H.; Prusiner, Stanley B.