2024

最新文章

• QnAs with Laura E. Wallace AI翻译
  作者：Hardcastle, Matthew
• Microevolutionary change in wild stickleback: Using integrative time- series data to infer responses to selection AI翻译
  作者：Strickland, Kasha; Matthews, Blake; Phillips, Joseph S.; Jonsson, Zophonias O.; Einarsson, Arni; Kristjansson, Bjarni K.; Rasanen, Katja
  作者单位：University of Edinburgh; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Iceland; Creighton University; Swiss Federal Institutes of Technology Domain; Swiss Federal Institute of Aquatic Science & Technology (EAWAG); University of Jyvaskyla
  摘要：A central goal in evolutionary biology is to understand how different evolutionary processes cause trait change in wild populations. However, quantifying evolutionary change in the wild requires linking trait change to shifts in allele frequencies at causal loci. Nevertheless, datasets that allow for such tests are extremely rare and existing theoretical approaches poorly account for the evolutionary dynamics that likely occur in ecological settings. Using a decade- long integrative phenome-to...
• Reversed I1Cu4 single- atom sites for superior neutral ammonia electrosynthesis with nitrate AI翻译
  作者：Zhou, Bing; Tong, Yawen; Yao, Yancai; Zhang, Weixing; Zhan, Guangming; Zheng, Qian; Hou, Wei; Gu, Xiang - Kui; Zhang, Lizhi
  作者单位：Central China Normal University; Shanghai Jiao Tong University; Wuhan University
  摘要：Electrochemical ammonia (NH3) synthesis from nitrate reduction (NITRR) offers an appealing solution for addressing environmental concerns and the energy crisis. However, most of the developed electrocatalysts reduce NO3- to NH3 via a hydrogen (H*)- mediated reduction mechanism, which suffers from undesired H*- H* dimerization to H2, resulting in unsatisfactory NH3 yields. Herein, we demonstrate that reversed I1Cu4 single- atom sites, prepared by anchoring iodine single atoms on the Cu surface,...
• HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA AI翻译
  作者：Capoferri, Adam A.; Wiegand, Ann; Hong, Feiyu; Jacobs, Jana L.; Spindler, Jonathan; Musick, Andrew; Bale, Michael J.; Shao, Wei; Sobolewski, Michele D.; Cillo, Anthony R.; Luke, Brian T.; Fennessey, Christine M.; Gorelick, Robert J.; Hoh, Rebecca; Halvas, Elias K.; Deeks, Steven G.; Coffin, John M.; Mellors, John W.; Kearney, Mary F.
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Georgetown University; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; Cornell University; Weill Cornell Medicine; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); Frederick National Laboratory for Cancer Research; University of California System; University of California San Francisco; Tufts University
  摘要：In the absence of antiretroviral therapy (ART), a subset of individuals, termed HIV controllers, have levels of plasma viremia that are orders of magnitude lower than non- controllers (NC) who are at higher risk for HIV disease progression. In addition to having fewer infected cells resulting in fewer cells with HIV RNA, it is possible that lower levels of plasma viremia in controllers are due to a lower fraction of the infected cells having HIV- 1 unspliced and quantitative single- cell seque...
• Heisenberg spin chain with random-sign couplings AI翻译
  作者：Fava, Michele; Jacobsen, Jesper Lykke; Nahum, Adam
  作者单位：Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS); Universite Paris Cite; Universite PSL; Sorbonne Universite; Sorbonne Universite; Universite Paris Cite; Centre National de la Recherche Scientifique (CNRS); Universite PSL; Ecole Normale Superieure (ENS)
  摘要：We study the 1D quantum Heisenberg chain with randomly ferromagnetic or antiferromagnetic couplings [a model previously studied by approximate strong- disorder renormalization group (RG)]. We find that, at least for sufficiently large spin S , the ground state has spin glass order. The spin waves on top of this state have the dynamical exponent z = 3/2, intermediate between the values z = 1 of the antiferromagnet and z = 2 of the ferromagnet. Density matrix renormalization group (DMRG) simulat...
• The limits of doing global, cross- cultural behavioral science research AI翻译
  作者：Gvirtz, Andres; Sabherwal, Anandita
  作者单位：University of London; King's College London; University of London; London School Economics & Political Science
• Insufficient evidence to conclude that confusion cannot explain cooperative behavior AI翻译
  作者：Fosgaard, Toke R.; Wengstrom, Erik
  作者单位：Technical University of Denmark; Lund University
• Reply to Fosgaard and Wengstrom: Confusion should not be used to explain cooperative behavior in public goods game experiments AI翻译
  作者：Wang, Guangrong; Li, Jianbiao; Wang, Wenhua; Niu, Xiaofei; Wang, Yue
  作者单位：Weifang University; Shandong University; Nankai University
• Circadian period is compensated for repressor protein turnover rates in single cells AI翻译
  作者：Gabriel, Christian H.; del Olmo, Marta; Widini, Arunya Rizki; Roshanbin, Rashin; Woyde, Jonas; Hamza, Ebrahim; Gutu, Nica- Nicoleta; Zehtabian, Amin; Ewers, Helge; Granada, Adrian; Herzel, Hanspeter; Kramer, Achim
  作者单位：Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Humboldt University of Berlin; Free University of Berlin; Charite Universitatsmedizin Berlin; Berlin Institute of Health; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin; Humboldt University of Berlin; Charite Universitatsmedizin Berlin; Free University of Berlin
  摘要：Most mammalian cells have molecular circadian clocks that generate widespread rhythms in transcript and protein abundance. While circadian clocks are robust to fluctuations in the cellular environment, little is known about the mechanisms by which the circadian period compensates for fluctuating metabolic states. Here, we exploit the heterogeneity of single cells both in circadian period and a metabolic parameter-protein stability-to study their interdependence without the need for genetic man...
• Conservation of kinetic stability, but not the unfolding mechanism, between human transthyretin and a transthyretin- related enzyme AI翻译
  作者：Jager, Marcus; Kelly, Jeffery W.; Gruebele, Martin
  作者单位：Scripps Research Institute; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign; University of Illinois System; University of Illinois Urbana-Champaign
  摘要：Kinetic stability is thought to be an attribute of proteins that require a long lifetime, such as the transporter of thyroxine and holo retinol- binding protein or transthyretin (TTR) functioning in the bloodstream, cerebrospinal fluid, and vitreous humor. TTR evolved from ancestral enzymes known as TTR- related proteins (TRPs). Here, we develop a rate- expansion approach that allows unfolding rates to be measured directly at low denaturant concentration, revealing that kinetic stability exist...