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作者：Aydin, Alhun; Keski-Rahkonen, Joonas; Heller, Eric J.
作者单位：Harvard University; Sabanci University; Tampere University; Harvard University
摘要：Strange metals exhibit universal linear-in-temperature resistivity described by a Planckian scattering rate, the origin of which remains elusive. By employing an approach inspired by quantum optics, we arrive at the coherent state representation of lattice vibrations: quantum acoustics. Utilizing this nonperturbative framework, we demonstrate that lattice vibrations could serve as active drivers in the Planckian resistivity phenomenon, challenging prevailing theories. By treating charge carrie...
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作者：Sewa, Agnele S.; Besser, Harrison A.; Mathews, Irimpan I.; Khosla, Chaitan
作者单位：Stanford University; Stanford University; Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
摘要：Mammalian transglutaminases, a family of Ca 2+- dependent proteins, are implicated in a variety of diseases. For example, celiac disease (CeD) is an autoimmune disorder whose pathogenesis requires transglutaminase 2 (TG2) to deamidate select glutamine residues in diet- derived gluten peptides. Deamidation involves the formation of transient gamma- glutamyl thioester intermediates. Recent studies have revealed that in addition to the deamidated gluten peptides themselves, their corresponding th...
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作者：Xu, Yi-Tong; Yu, Si-Yuan; Li, Zheng; Kou, Bo-Han; Pang, Jian-Xiang; Zhao, Wei-Wei; Chen, Hong-Yuan; Xu, Jing-Juan
作者单位：Nanjing University
摘要：Currently, the nanofluidic synapse can only perform basic neuromorphic pulse patterns. One immediate problem that needs to be addressed to further its capability of brain- like computing is the realization of a nanofluidic spiking device. Here, we report the use of a poly(3,4- ethylenedioxythiophene) polystyrene sulfonate membrane to achieve bionic ionic current- induced spiking. In addition to the simulation of various electrical pulse patterns, our synapse could produce transmembrane ionic c...
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作者：Behnia, Kamran
作者单位：Universite PSL; Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI); Sorbonne Universite; Centre National de la Recherche Scientifique (CNRS)
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作者：Zubia, Mario V.; Yong, Adeline J. H.; Holtz, Kristen M.; Huang, Eric J.; Jan, Yuh Nung; Bcd, Lily Y. Jan
作者单位：University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Howard Hughes Medical Institute; University of California System; University of California San Francisco
摘要：TMEM16F is a calcium - activated phospholipid scramblase and nonselective ion channel, which allows the movement of lipids bidirectionally across the plasma membrane. While the functions of TMEM16F have been extensively characterized in multiple cell types, the role of TMEM16F in the central nervous system remains largely unknown. Here, we sought to study how TMEM16F in the brain may be involved in neurodegeneration. Using a mouse model that expresses the pathological P301S human tau (PS19 mou...
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作者：Aldeias, Vera; Stahlschmidt, Mareike C.
作者单位：Universidade do Algarve; University of Vienna; University of Vienna
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作者：Faissner, Simon; Motte, Jeremias; Sgodzai, Melissa; Geis, Christian; Haghikia, Aiden; Mougiakakos, Dimitrios; Borie, Dominic; Schroers, Roland; Gold, Ralf
作者单位：Ruhr University Bochum; Friedrich Schiller University of Jena; Otto von Guericke University; Otto von Guericke University; Ruhr University Bochum
摘要：Treatment with autologous chimeric antigen receptor (CAR) T cells has emerged as a highly effective approach in neuroimmunological disorders such as myasthenia gravis. We report a case of successful anti - CD19 CAR T cell use in treatment - refractory stiff - person syndrome (SPS). To investigate clinical and immunological effects of anti - CD19 CAR T cell use in treatment - refractory SPS, a 69 - y - old female with a 9 - y history of treatment - refractory SPS with deteriorating episodes of ...
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作者：Truc, B.; Usai, P.; Pennacchio, F.; Berruto, G.; Claude, R.; Madan, I.; Sala, V.; LaGrange, T.; Vanacore, G. M.; Benhabib, S.; Carbone, F.
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne; Polytechnic University of Milan; University of Milano-Bicocca; Universite Paris Saclay; Centre National de la Recherche Scientifique (CNRS)
摘要：Phase transitions occurring in nonequilibrium conditions can evolve through high -energy intermediate states inaccessible via equilibrium adiabatic conditions. Because of the subtle nature of such hidden phases, their direct observation is extremely challenging and requires simultaneous visualization of matter at subpicoseconds and subpicometer scales. Here, we show that a magnetite crystal in the vicinity of its metal-to-insulator transition evolves through different hidden states when contro...
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作者：Bloome, Deirdre; Opacic, Aleksei
作者单位：Harvard University; Harvard University
摘要：Intergenerational mobility captures the distance between the socioeconomic positions of parents versus their adult children. Researchers measure this distance in absolute and relative units, such as absolute dollars and relative ranks. Absolute and relative mobility often diverge. For example, absolute mobility can rise while relative mobility declines. How should scholars and policymakers understand this divergence? We conclude that they should understand it as follows: absolute mobility is l...
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作者：Condezo, Yazmine B.; Sainz-Urruela, Raquel; Gomez-H, Laura; Salas-Lloret, Daniel; Felipe-Medina, Natalia; Bradley, Rachel; Wolff, Ian D.; Tanis, Stephanie; Barbero, Jose Luis; Sanchez-Martin, Manuel; de Rooij, Dirk; Hendriks, Ivo A.; Nielsen, Michael L.; Gonzalez-Prieto, Roman; Cohen, Paula E.; Pendas, Alberto M.; Llano, Elena
作者单位：University of Salamanca; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC-USAL - Instituto de Biologia Molecular y Celular del Cancer de Salamanca (IBMCC); University of Salamanca; Max Planck Society; Leiden University; Leiden University Medical Center (LUMC); Cornell University; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Centro de Investigaciones Biologicas (CIB); University of Salamanca; Utrecht University; University of Copenhagen; Consejo Superior de Investigaciones Cientificas (CSIC); Universidad Pablo de Olavide; University of Sevilla; CSIC - Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER); University of Sevilla; University of Salamanca
摘要：Meiosis, a reductional cell division, relies on precise initiation, maturation, and resolution of crossovers (COs) during prophase I to ensure the accurate segregation of homologous chromosomes during metaphase I. This process is regulated by the interplay of RING- E3 ligases such as RNF212 and HEI10 in mammals. In this study, we functionally characterized a recently identified RING- E3 ligase, RNF212B. RNF212B colocalizes and interacts with RNF212, forming foci along chromosomes from zygonema...
