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作者：Wang, Ziqi; de Wit, Xander M.; Toschi, Federico
作者单位：Eindhoven University of Technology; Consiglio Nazionale delle Ricerche (CNR)
摘要：Small bubbles in fluids rise to the surface due to Archimede's force. Remarkably, in turbulent flows this process is severely hindered by the presence of vortex filaments, which act as moving potential wells, dynamically trapping light particles and bubbles. Quantifying the statistical weights and roles of vortex filaments in turbulence is, however, still an outstanding experimental and computational challenge due to their small scale, fast chaotic motion, and transient nature. Here we show th...
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作者：Boros, Laszlo G.; Seneff, Stephanie; Turi, Marianna; Palcsu, Laszlo; Zubarev, Roman A.
作者单位：Vrije Universiteit Amsterdam; Massachusetts Institute of Technology (MIT); HUN-REN; HUN-REN Institute for Nuclear Research; Karolinska Institutet; Sechenov First Moscow State Medical University; Russian Academy of Medical Sciences; Endocrinology Research Centre
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作者：Coker, Jack F.; Moro, Stefania; Gertsen, Anders S.; Shi, Xingyuan; Pearce, Drew; van der Schelling, Martin P.; Xu, Yuchen; Zhang, Weimin; Andreasen, Jens W.; Snyder, Chad R.; Richter, Lee J.; Bird, Matthew J.; McCulloch, Iain; Costantini, Giovanni; Frost, Jarvist M.; Nelson, Jenny
作者单位：Imperial College London; University of Birmingham; Technical University of Denmark; Delft University of Technology; University of Cambridge; King Abdullah University of Science & Technology; National Institute of Standards & Technology (NIST) - USA; United States Department of Energy (DOE); Brookhaven National Laboratory; University of Oxford; Imperial College London
摘要：The nature of interchain it- system contacts, and their relationship to hole transport, are elucidated for the high- mobility, noncrystalline conjugated polymer C16-IDTBT by the application of scanning tunneling microscopy, molecular dynamics, and quantum chemical calculations. The microstructure is shown to favor an unusual packing motif in which paired chains cross- over one another at near- perpendicular angles. By linking to mesoscale microstructural features, revealed by coarse- grained m...
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作者：Wu, Z.; Weinberger, T. I.; Chen, J.; Cabala, A.; Chichinadze, D. V.; Shaffer, D.; Pospisil, J.; Prokleska, J.; Haidamak, T.; Bastien, G.; Sechovsky, V.; Hickey, A. J.; Mancera-Ugarte, M. J.; Benjamin, S.; Graf, D. E.; Skourski, Y.; Lonzarich, G. G.; Valiska, M.; Grosche, F. M.; Eaton, A. G.
作者单位：University of Cambridge; Charles University Prague; State University System of Florida; Florida State University; Emory University; University of Wisconsin System; University of Wisconsin Madison; University of Cambridge; Helmholtz Association; Helmholtz-Zentrum Dresden-Rossendorf (HZDR)
摘要：The unconventional superconductor UTe2 exhibits numerous signatures of spin-triplet superconductivity-a rare state of matter which could enable quantum computation protected against decoherence. UTe2 possesses a complex phase landscape comprising two magnetic field-induced superconducting phases, a metamagnetic transition to a field-polarized state, along with pair- and charge-density wave orders. However, contradictory reports between studies performed on UTe2 specimens of varying quality hav...
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作者：Lin, Guowu; Barnes, Christopher O.; Weiss, Simon; Dutagaci, Bercem; Qiu, Chenxi; Feig, Michael; Song, Jihnu; Lyubimov, Artem; Cohen, Aina E.; Kaplan, Craig D.; Calero, Guillermo
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; California Institute of Technology; Michigan State University; Harvard University; Harvard Medical School; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Stanford University; University of California System; University of California Merced
摘要：Catalysis and translocation of multisubunit DNA-directed RNA polymerases underlie all cellular mRNA synthesis. RNA polymerase II (Pol II) synthesizes eukaryotic pre-mRNAs from a DNA template strand buried in its active site. Structural details of catalysis at near-atomic resolution and precise arrangement of key active site components have been elusive. Here, we present the free-electron laser (FEL) structures of a matched ATP-bound Pol II and the hyperactive Rpb1 T834P bridge helix (BH) mutan...
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作者：Zhu, Changan; Hu, Zhangjian; Hu, Chaoyi; Ma, Hongxue; Zhou, Jie; Xia, Xiaojian; Shi, Kai; Foyer, Christine H.; Yu, Jingquan; Zhou, Yanhong
作者单位：Zhejiang University; Zhejiang University; Zhejiang University; University of Birmingham
摘要：ELONGATED HYPOCOTOYL5 (HY5) and PHYTOCHROME INTERACTING FACTORs (PIFs) are two types of important light- related regulators of plant growth, however, their interplay remains elusive. Here, we report that the activated tomato ( Solanum lycopersicum) HY5 (SlHY5) triggers the transcription of a Calcium- dependent Protein Kinase SlCPK27. SlCPK27 interacts with and phosphorylates SlPIF4 at Ser-252 and Ser-308 phosphosites to promote its degradation. SlPIF4 promotes hypocotyl elongation mainly by ac...
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作者：Dahal, Ankit; Hong, Yeonsun; Mathew, Jocelyn S.; Geber, Adam; Eckl, Sarah; Renner, Stephanie; Sailer, Cooper J.; Ryan, Allison T.; Mir, Sana; Lim, Kihong; Linehan, David C.; Gerber, Scott A.; Kim, Minsoo
作者单位：University of Rochester; University of Rochester; University of Rochester; University of Rochester
摘要：Chronic inflammatory milieu in the tumor microenvironment (TME) leads to the recruitment and differentiation of myeloid- derived suppressor cells (MDSCs). Polymorphonuclear (PMN)- MDSCs, which are phenotypically and morphologically defined as a subset of neutrophils, cause major immune suppression in the TME, posing a significant challenge in the development of effective immunotherapies. Despite recent advances in our understanding of PMN-MDSC functions, the mechanism that gives rise to immuno...
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作者：Maki-Marttunen, Tuomo; Blackwell, Kim T.; Akkouh, Ibrahim; Shadrin, Alexey; Valstad, Mathias; Elvsashagen, Torbjorn; Linne, Marja-Leena; Djurovic, Srdjan; Einevoll, Gaute T.; Andreassen, Ole A.
作者单位：Tampere University; University of Oslo; University of Iowa; University of Oslo; University of Oslo; University of Oslo; University of Oslo; Norwegian Institute of Public Health (NIPH); University of Oslo; Norwegian University of Life Sciences; University of Oslo; University of Oslo
摘要：Schizophrenia phenotypes are suggestive of impaired cortical plasticity in the disease, but the mechanisms of these deficits are unknown. Genomic association studies have implicated a large number of genes that regulate neuromodulation and plasticity, indicating that the plasticity deficits have a genetic origin. Here, we used biochemically detailed computational modeling of postsynaptic plasticity to investigate how schizophrenia-associated genes regulate long-term potentiation (LTP) and depr...
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作者：Croswell, Ken
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作者：Gaete, Pablo S.; Kumar, Deepak; Fernandez, Cynthia I.; Capuccino, Juan M. Valdez; Bhatt, Aashish; Jiang, Wenjuan; Lin, Yi - Chun; Liu, Yu; Harris, Andrew L.; Luo, Yun L.; Contreras, Jorge E.
作者单位：University of California System; University of California Davis; Western University of Health Sciences; Rutgers University System; Rutgers University New Brunswick; Rutgers University Biomedical & Health Sciences; Rutgers University Newark
摘要：Connexin hemichannels were identified as the first members of the eukaryotic large- pore channel family that mediate permeation of both atomic ions and small molecules between the intracellular and extracellular environments. The conventional view is that their pore is a large passive conduit through which both ions and molecules diffuse in a similar manner. In stark contrast to this notion, we demonstrate that the permeation of ions and of molecules in connexin hemichannels can be uncoupled a...
