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作者：Goodson, Boyd M.; Chekmenev, Eduard Y.
作者单位：Southern Illinois University System; Southern Illinois University; Southern Illinois University System; Southern Illinois University; Wayne State University; Barbara Ann Karmanos Cancer Institute
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作者：Kumar, Ajay; Ye, Chenxian; Nkansah, Afia; Decoville, Thomas; Sajjakulnukit, Peter; Zhang, Li; Fogo, Garrett M.; Reynolds, Mack B.; Seo, Young-Ah; Sanderson, Thomas H.; Lyssiotis, Costas A.; Chang, Cheong-Hee
作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
摘要：In response to an immune challenge, naive T cells undergo a transition from a quiescent to an activated state acquiring the effector function. Concurrently, these T cells reprogram cellular metabolism, which is regulated by iron. We and others have shown that iron homeostasis controls proliferation and mitochondrial function, but the underlying mechanisms are poorly understood. Given that iron derived from heme makes up a large portion of the cellular iron pool, we investigated iron homeostasi...
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作者：Wang, Camille S.; Mccarthy, Clara I.; Guzikowski, Natalie J.; Kavalali, Ege T.; Monteggia, Lisa M.
作者单位：Vanderbilt University; Vanderbilt University
摘要：Brain - derived neurotrophic factor (BDNF) plays a critical role in synaptic physiology, as well as mechanisms underlying various neuropsychiatric diseases and their treatment. Despite its clear physiological role and disease relevance, BDNF's function at the presynaptic terminal, a fundamental unit of neurotransmission, remains poorly understood. In this study, we evaluated single synapse dynamics using optical imaging techniques in hippocampal cell cultures. We find that exogenous BDNF selec...
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作者：Yu, Renwen; Fan, Shanhui
作者单位：Stanford University
摘要：Near -field radiative heat transfer has recently attracted increasing interests for its applications in energy technologies, such as thermophotovoltaics. Existing works, however, are restricted to time -independent systems. Here, we explore near -field radiative heat transfer between two bodies under time modulation by developing a rigorous fluctuational electrodynamics formalism. We demonstrate that time modulation can result in the enhancement, suppression, elimination, or reversal of radiat...
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作者：Baizhikova, Zheren; Ballarini, Roberto; Le, Jia-Liang
作者单位：University of Houston System; University of Houston; University of Minnesota System; University of Minnesota Twin Cities
摘要：Localized deformation and randomly shaped imperfections are salient features of buckling -type instabilities in thin -walled load -bearing structures. However, it is generally agreed that their complex interactions in response to mechanical loading are not yet sufficiently understood, as evidenced by buckling -induced catastrophic failures which continue to today. This study investigates how the intimate coupling between localization mechanisms and geometric imperfections combine to determine ...
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作者：Hillyard, Steven A.; Andersen, Soren K.
作者单位：University of Southern Denmark; University of Aberdeen; University of California System; University of California San Diego; Leibniz Association; Leibniz Institut fur Neurobiologie (LIN)
摘要：Research on attentional selection of stimulus features has yielded seemingly contradictory results. On the one hand, many experiments in humans and animals have observed a global facilitation of attended features across the entire visual field, even when spatial attention is focused on a single location. On the other hand, several event- related potential studies in humans reported that attended features are enhanced at the attended location only. The present experiment demonstrates that these...
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作者：Mirarab, Siavash; Rivas-Gonzalez, Iker; Feng, Shaohong; Stiller, Josefin; Fang, Qi; Mai, Uyen; Hickey, Glenn; Chen, Guangji; Brajuka, Nadolina; Fedrigo, Olivier; Formenti, Giulio; Wolf, Jochen B. W.; Howe, Kerstin; Antunes, Agostinho; Schierup, Mikkel H.; Paten, Benedict; Jarvis, Erich D.; Zhang, Guojie; Braun, Edward L.
作者单位：University of California System; University of California San Diego; Aarhus University; Zhejiang University; Liangzhu Laboratory; Zhejiang University; University of Copenhagen; University of California System; University of California Santa Cruz; Rockefeller University; University of Munich; Wellcome Trust Sanger Institute; Universidade do Porto; Universidade do Porto; State University System of Florida; University of Florida
摘要：Genomes are typically mosaics of regions with different evolutionary histories. When speciation events are closely spaced in time, recombination makes the regions sharing the same history small, and the evolutionary history changes rapidly as we move along the genome. When examining rapid radiations such as the early diversification of Neoaves 66 Mya, typically no consistent history is observed across segments exceeding kilobases of the genome. Here, we report an exception. We found that a 21-...
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作者：Peng, Zhaoxin; Song, Lizhi; Chen, Minghua; Liu, Zeyang; Yuan, Ziyu; Wen, Huan; Zhang, Haipeng; Huang, Yue; Peng, Zhaowen; Yang, Hongbin; Li, Gu; Zhang, Huixian; Hu, Zhehui; Li, Wenyun; Wang, Xia; Larkin, Robert M.; Deng, Xiuxin; Xu, Qiang; Chen, Jiajing
作者单位：Huazhong Agricultural University; Hubei Hongshan Laboratory; Henan Agricultural University; Guizhou Academy of Agricultural Sciences
摘要：Polymethoxyflavones (PMFs) are a class of abundant specialized metabolites with remarkable anticancer properties in citrus. Multiple methoxy groups in PMFs are derived from methylation modification catalyzed by a series of hydroxylases and O- methyltransferases (OMTs). However, the specific OMTs that catalyze the systematic O- methylation of hydroxyflavones remain largely unknown. Here, we report that PMFs are highly accumulated in wild mandarins and mandarin- derived accessions, while undetec...
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作者：Li, Wen-Zhen; Wang, Xiao-Qiang; Liu, Ling-Ran; Xiao, Ju; Wang, Xin-Qiong; Ye, Yu-Yuan; Zhu, Mai-Yong; Sun, Yan; Stang, Peter J.; Sun, Yao
作者单位：Wuhan University of Science & Technology; Henan University; Jiangsu University; Shanghai Jiao Tong University; Central China Normal University; Utah System of Higher Education; University of Utah
摘要：The exploitation of novel wound healing methods with real - time infection sensing and high spatiotemporal precision is highly important for human health. Pt - based metal- organic cycles/cages (MOCs) have been employed as multifunctional antibacterial agents due to their superior Pt- related therapeutic efficiency, various functional subunits and specific geometries. However, how to rationally apply these nanoscale MOCs on the macroscale with controllable therapeutic output is still challengi...
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作者：Liang, Junyi; Seghiri, Mohamed; Singh, Pradeep Kumar; Seo, Hyeon Gyu; Lee, Ji Yeong; Jo, Yoonjung; Song, Yong Bhum; Park, Chulo; Zalicki, Piotr; Jeong, Jae- Yeon; Huh, Won-Ki; Caculitan, Nina G.; Smith, Adam W.
作者单位：Cleveland Clinic Foundation; University System of Ohio; University of Akron; Texas Tech University System; Texas Tech University; Seoul National University (SNU); Seoul National University (SNU)
摘要：While the existence and functional role of class C G- protein- coupled receptors (GPCR) dimers is well established, there is still a lack of consensus regarding class A and B GPCR multimerization. This lack of consensus is largely due to the inherent challenges of demonstrating the presence of multimeric receptor complexes in a physiologically relevant cellular context. The C- X- C motif chemokine receptor 4 (CXCR4) is a class A GPCR that is a promising target of anticancer therapy. Here, we i...
