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作者：Garbett, Krassimira; Tosun, Baris; Lopez, Jaybree M.; Smith, Cassandra M.; Honkanen, Kelly; Sando, Richard C.
作者单位：Vanderbilt University
摘要：Combinatorial networks of cell adhesion molecules and cell surface receptors drive fundamental aspects of neural circuit establishment and function. However, the intracellular signals orchestrated by these cell surface complexes remain less understood. Here, we report that the G alpha 12/13 pathway lies downstream of several GPCRs with critical synaptic functions. Impairment of the G alpha 12/13 pathway in postnatal hippocampal neurons diminishes inhibitory inputs without altering neuronal mor...
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作者：Muetter, Malte; Angst, Daniel C.; Regoes, Roland R.; Bonhoeffer, Sebastian
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
摘要：The issue of antibiotic resistance is a critical concern for public health, prompting numerous investigations into the impact of treatment strategies on preventing or slowing down the emergence of resistance. While existing studies have predominantly focused on chromosomal resistance mutations, the consequences of often clinically more relevant plasmid-conferred resistance remain insufficiently explored. To address this gap, we conducted three extensive in vitro experiments utilizing a liquid-...
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作者：Isay, Sophie E.; Vornholz, Larsen; Schnalzger, Theresa; Groll, Tanja; Magg, Thomas; Loll, Patricia; Weirich, Gregor; Steiger, Katja; Hauck, Fabian; Ruland, Juergen
作者单位：Technical University of Munich; Technical University of Munich; Technical University of Munich; University of Munich; Helmholtz Association; German Cancer Research Center (DKFZ); Technical University of Munich; German Center for Infection Research
摘要：Hemophagocytic lymphohistiocytosis (HLH) is a life- threatening syndrome fueled by uncontrolled mononuclear phagocyte activity, yet the innate immune mechanisms driving HLH pathogenesis remain elusive. Germline gain- of- function (GOF) mutations in CARD11, a pivotal regulator of lymphocyte antigen receptor signaling, cause the is frequently associated with HLH development. Given that CARD11 is physiologically expressed not only in lymphocytes but also in dendritic cells (DCs), we explored whet...
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作者：Aimutis, William R.; Shirwaiker, Rohan
作者单位：North Carolina State University; North Carolina State University; North Carolina State University
摘要：Plant- based proteins are promoted as nutritious, environ mentallysafe, and a keyelementforfood security. Numerous studies using environmental life cycle assessments confirmed plant- based meat alternatives are more environmentally favorable than animal- derived meat. However, most missed other factors from protein extraction and concentration that contribute to environmental impact (both positive and negative). Furthermore, few studies examined the entire environmental impact because they ove...
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作者：Yan, Luyao; Cao, Xiaodan; Wang, Lijuan; Chen, Jie; Sancar, Aziz; Zhong, Dongping
作者单位：Shanghai Jiao Tong University; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Photolyase and cryptochrome belong to a group of structurally similar flavoproteins but with two distinct functions of DNA repair as a photoenzyme and signal transduction as a photoreceptor, respectively, under blue- light illumination. Here, we studied a recently discovered bifunctional Chlamydomonas reinhardtii cryptochrome (CraCRY) with focus on its repair of UV- induced pyrimidine- pyrimidone (6- 4) photoproduct (6-4PP). We used femtosecond spectroscopy and site- directed mutagenesis to ma...
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作者：Zanders, Sarah E.; Smith, Gerald R.
作者单位：Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center; Fred Hutchinson Cancer Center
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作者：Fine, Cordelia; Cope, Liz; Elliott, Lucienne; Matthews, Chloe A.; Muscat, Madison; Polowyj, Christine; Warren, Harvey L.
作者单位：University of Melbourne
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作者：Shen, Chen; He, Zhixue; Guo, Hao; Hu, Shuyue; Tanimoto, Jun; Shi, Lei; Holme, Petter
作者单位：Kyushu University; Yunnan University of Finance & Economics; Kyushu University; Tsinghua University; Aalto University; Kobe University
摘要：Stylized experiments, the public goods game and its variants thereof, have taught us the peculiar reproducible fact that humans tend to cooperate (or contribute to shared resources) more than expected from economically rational assumptions. There have been two competing explanations for this phenomenon: Either cooperating is an innate human trait (the prosocial preference hypothesis) or a transitory effect while learning the game (the confused learner hypothesis). We use large-scale experiment...
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作者：Kousky, Carolyn; Treuer, Galen; Mach, Katharine J.
作者单位：University of Miami; University of Miami
摘要：Climate change poses complex risks without precedent that challenge established planning and risk management tools, including property insurance. The nature and timing of transitions in markets and institutions in response to growing climate risks will shape prospects for future socioeconomic well- being. As property insurance markets in the United States face higher levels of turmoil, policymakers are weighing various interventions to stabilize not only insurance but also housing and mortgage...
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作者：Nugent, Thomas W.; Zele, Andrew J.
作者单位：Queensland University of Technology (QUT)
摘要：A subpopulation of human retinal ganglion cells contains the melanopsin photopigment, allowing them to act as a fifth photoreceptor class. These ganglion cells project to the visual cortex, but to reveal its intrinsic contribution to conscious vision is technically challenging as it requires melanopsin to be separated from the responses originating in the rods and three cone classes. Using a display engineered to isolate the melanopic visual response, we show that it detects lowpass spatial (<...
