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作者：Hart, James L.; Pan, Haining; Siddique, Saif; Schnitzer, Noah; Mallayya, Krishnanand; Xu, Shiyu; Kourkoutis, Lena F.; Kim, Eun-ah; Cha, Judy J.
作者单位：Cornell University; Cornell University; Cornell University; Cornell University; Ewha Womans University
摘要：We study the coupled charge density wave (CDW) and insulator-to-metal transitions in the 2D quantum material 1T-TaS2. By applying in situ cryogenic 4D scanning transmission electron microscopy with in situ electrical resistance measurements, we directly visualize the CDW transition and establish that the transition is mediated by basal dislocations (stacking solitons). We find that dislocations can both nucleate and pin the transition and locally alter the transition temperature T-c by nearly ...
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作者：Liu, Xingyu; Zhang, Ying; Wen, Zhihui; Hao, Yan; Banks, Charles A. S.; Cesare, Joseph; Bhattacharya, Saikat; Arvindekar, Shreyas; Lange, Jeffrey J.; Xie, Yixuan; Garcia, Benjamin A.; Slaughter, Brian D.; Unruh, Jay R.; Viswanath, Shruthi; Florens, Laurence; Workman, Jerry L.; Washburn, Michael P.
作者单位：Stowers Institute for Medical Research; University of Kansas; University of Kansas Medical Center; Tata Institute of Fundamental Research (TIFR); National Centre for Biological Sciences (NCBS); Washington University (WUSTL); University of Texas System; University of Texas Southwestern Medical Center; University of Kansas; University of Kansas Medical Center
摘要：Serial capture affinity purification (SCAP) is a powerful method to isolate a specific protein complex. When combined with cross- linking mass spectrometry and computational approaches, one can build an integrated structural model of the isolated complex. Here, we applied SCAP to dissect a subpopulation of WDR76 in complex with SPIN1, a histone reader that recognizes trimethylated histone H3 lysine4 (H3K4me3). In contrast to a previous SCAP analysis of the SPIN1:SPINDOC complex, histones and t...
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作者：Farrell, Matthew; Pehlevan, Cengiz
作者单位：Harvard University; Harvard University; Harvard University; RIKEN
摘要：Understanding how neural circuits generate sequential activity is a longstanding challenge. While foundational theoretical models have shown how sequences can be stored as memories in neural networks with Hebbian plasticity rules, these models considered only a narrow range of Hebbian rules. Here, we introduce a model for arbitrary Hebbian plasticity rules, capturing the diversity of spike-timing-dependent synaptic plasticity seen in experiments, and show how the choice of these rules and of n...
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作者：Power, Mary E.; Chandra, Sudeep; Gleick, Peter; Dietrich, William E.
作者单位：University of California System; University of California Berkeley; Nevada System of Higher Education (NSHE); University of Nevada Reno; University of California System; University of California Berkeley
摘要：As human- caused climate changes accelerate, California will experience hydrologic and temperature conditions different than any encountered in recorded history. How will these changes affect the state's freshwater ecosystems? Rivers, lakes, and wetlands are managed as a water resource, but they also support a complex web of life, ranging from bacteria, fungi, and algae to macrophytes, woody plants, invertebrates, fish, amphibians, reptiles, birds, and mammals. In much of the state, native fre...
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作者：Zytnick, Alexa M.; Gutenthaler-Tietze, Sophie M.; Aron, Allegra T.; Reitz, Zachary L.; Phi, Manh Tri; Good, Nathan M.; Petras, Daniel; Daumann, Lena J.; Martinez-Gomez, Norma Cecilia
作者单位：University of California System; University of California Berkeley; University of Munich; Heinrich Heine University Dusseldorf; University of Denver; Wageningen University & Research; University of California System; University of California Santa Barbara; Eberhard Karls University of Tubingen
摘要：Many bacteria secrete metallophores, low- molecular- weight organic compounds that bind ions with high selectivity and affinity, in order to access essential metals from the environment. Previous work has elucidated the structures and biosynthetic machinery of metallophores specific for iron, zinc, nickel, molybdenum, and copper. No physiologically relevant lanthanide- binding metallophore has been discovered despite the knowledge that lanthanide metals (Ln) have been revealed to be essential ...
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作者：Pornour, Majid; Jeon, Hee - Young; Ryu, Hyunju; Khadka, Sudeep; Xu, Rui; Chen, Hegang; Hussain, Arif; Lam, Hung - Ming; Zhuang, Zhihao; Oo, Htoo Zarni; Gleave, Martin; Dong, Xuesen; Wang, Qianben; Barbieri, Christopher; Qi, Jianfei
作者单位：University System of Maryland; University of Maryland Baltimore; University System of Maryland; University of Maryland Baltimore; University of Maryland Center for Environmental Science; Institute of Marine & Environmental Technology; University System of Maryland; University of Maryland Baltimore; US Department of Veterans Affairs; Veterans Health Administration (VHA); Baltimore VA Medical Center; University of Washington; University of Washington Seattle; University of Delaware; University of British Columbia; Duke University; Duke University; Cornell University; Weill Cornell Medicine
摘要：Androgen receptor (AR) is a main driver for castration- resistant prostate cancer (CRPC). c-Myc is an oncogene underlying prostate tumorigenesis. Here, we find that the deubiquitinase USP11 targets both AR and c-Myc in prostate cancer (PCa). USP11 expression was up- regulated in metastatic PCa and CRPC. USP11 knockdown (KD) significantly inhibited PCa cell growth. Our RNA-seq studies revealed AR and c-Myc as the top transcription factors altered after USP11 KD. ChIP-seq analysis showed that ei...
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作者：Roach, Shanley N.; Shepherd, Frances K.; Mickelson, Clayton K.; Fiege, Jessica K.; Thielen, Beth K.; Pross, Lauren M.; Sanders, Autumn E.; Mitchell, Jason S.; Robertson, Mason; Fife, Brian T.; Langlois, Ryan A.
作者单位：University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities
摘要：Influenza viruses pose a significant burden on global human health. Influenza has a broad cellular tropism in the airway, but how infection of different epithelial cell types impacts replication kinetics and burden in the airways is not fully understood. Using primary human airway cultures, which recapitulate the diverse epithelial cell landscape of the human airways, we investigated the impact of cell type composition on virus tropism and replication kinetics. Cultures were highly diverse acr...
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作者：Juliano, Celina E.
作者单位：University of California System; University of California Davis
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作者：Veno, Morten T.; Reschke, Cristina R.; Morris, Gareth; Connolly, Niamh M. C.; Su, Junyi; Yan, Yan; Engel, Tobias; Jimenez-Mateos, Eva M.; Harder, Lea M.; Pultz, Dennis; Haunsberger, Stefan J.; Pal, Ajay; Heller, Janosch P.; Campbell, Aoife; Langa, Elena; Brennan, Gary P.; Conboy, Karen; Richardson, Amy; Norwood, Braxton A.; Costard, Lara S.; Neubert, Valentin; Del Gallo, Federico; Salvetti, Beatrice; Vangoor, Vamshidhar R.; Sanz-Rodriguez, Amaya; Muilu, Juha; Fabene, Paolo F.; Pasterkamp, R. Jeroen; Prehn, Jochen H. M.; Schorge, Stephanie; Andersen, Jens S.; Rosenow, Felix; Bauer, Sebastian; Kjems, Jorgen; Henshall, David C.
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作者：Wang, Pei Lin; Teng, Liu; Feng, Yu Chen; Yue, Yi Meng; Han, Man Man; Yan, Qianqian; Ye, Kaihong; Tang, Cai Xia; Zhang, Sheng Nan; Qi, Teng Fei; Zhao, Xiao Hong; La, Ting; Zhang, Yuan Yuan; Li, Jin Ming; Hu, Bin; Xu, Dengfei; Cang, Shundong; Wang, Li; Jin, Lei; Thorne, Rick F.; Zhang, Yuwei; Liu, Tao; Zhang, Xu Dong
