2024

最新文章

• Targeted engineering of camelina and pennycress seeds for ultrahigh accumulation of acetyl- TAG AI翻译
  作者：Alkotami, Linah; White, Dexter J.; Schuler, Kathleen M.; Esfahanian, Maliheh; Jarvis, Brice A.; Paulson, Andrew E.; Koley, Somnath; Kang, Jinling; Lu, Chaofu; Allen, Doug K.; Lee, Young-Jin; Sedbrook, John C.; Durrett, Timothy P.
  作者单位：Kansas State University; Kansas State University; Illinois State University; Iowa State University; Donald Danforth Plant Science Center; Montana State University System; Montana State University Bozeman; United States Department of Agriculture (USDA)
  摘要：Acetyl- TAG (3- acetyl- 1,2- diacylglycerol), unique triacylglycerols (TAG) possessing an acetate group at the sn-3 position, exhibit valuable properties, such as reduced viscosity and freezing points. Previous attempts to engineer acetyl- TAG production in oilseed crops did not achieve the high levels found in naturally producing Euonymus seeds. Here, we demonstrate the successful generation of camelina and pennycress transgenic lines accumulating nearly pure acetyl- TAG at 93 mol% and 98 mol...
• The glucocorticoid receptor potentiates aldosterone- induced transcription by the mineralocorticoid receptor AI翻译
  作者：Johnson, Thomas A.; Fettweis, Gregory; Wagh, Kaustubh; Heras, Diego Ceacero -; Krishnamurthy, Manan; de Medina, Fermin Sanchez; Martinez-Augustin, Olga; Upadhyaya, Arpita; Hager, Gordon L.; de la Rosa, Diego Alvarez
  作者单位：National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI); University System of Maryland; University of Maryland College Park; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University of Granada; University of Granada; CIBER - Centro de Investigacion Biomedica en Red; CIBEREHD; University System of Maryland; University of Maryland College Park; Universidad de la Laguna; Universidad de la Laguna
  摘要：The glucocorticoid , mineralocorticoid receptors (GR and MR, respectively) have distinct, yet overlapping physiological and pathophysiological functions. There are indi- cations that both receptors interact functionally and physically, but the precise role of this interdependence is poorly understood. Here, we analyzed the impact of GR coex- pression on MR genome- wide- wide transcriptional responses and chromatin binding upon activation by aldosterone and glucocorticoids, both physiological l...
• Phenotypic screening of the ReFRAME drug repurposing library to discover new drugs for treating sickle cell disease (vol 119, e2210779119, 2022) AI翻译
  作者：Metaferia, Belhu; Cellmer, Troy; Dunkelberger, Emily B.; Li, Quan; Henry, Eric R.; Hofrichter, James; Staton, Dwayne; Hsieh, Matthew M.; Conrey, Anna K.; Tisdale, John F.; Chatterjee, Arnab K.; Thein, Swee Lay; Eaton, William A.
• Can microbiome adaptations protect crops from pests and climate change? AI翻译
  作者：Beans, Carolyn
• Linking metabolic and epigenetic changes in immune tolerance AI翻译
  作者：Sheedy, Frederick J.; Kaufmann, Eva
  作者单位：Trinity College Dublin; Queens University - Canada
• Robust extraction of pneumonia-associated clinical states from electronic health records AI翻译
  作者：Xu, Feihong; Morales, Felix L.; Amaral, Luis A. Nunes
  作者单位：Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University; Northwestern University
  摘要：Mining of electronic health records (EHR) promises to automate the identification of comprehensive disease phenotypes. However, the realization of this promise is hindered by the unavailability of generalizable ground-truth information, data incompleteness and heterogeneity, and the lack of generalization to multiple cohorts. We present here a data-driven approach to identify clinical states that we implement for 585 critical care patients with suspected pneumonia recruited by the SCRIPT study...
• The surface interface and swimming motility influence surface- sensing responses in Pseudomonas aeruginosa (vol 121, e2411981121, 2024) AI翻译
  作者：Zhen, Xuhui; Gomez-Rivas, Emma J.; Lamont, Sabrina I.; Daneshjoo, Katayoun; Shieh, Angeli; Wozniak, Daniel J.; Parsek, Matthew R.
• Tolerance and efficient metabolization of extremely high ethanol concentrations by a social wasp AI翻译
  作者：Bouchebti, Sofia; Gershon, Yael; Gordin, Alexander; Huchon, Dorothee; Levin, Eran
  作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv University; Ben-Gurion University of the Negev
  摘要：Ethanol, a natural by- product of sugar fermentation, can be found in various fruits and nectar. Although many animals routinely consume ethanol in low concentrations as part of their natural diets, its inherent toxicity can cause severe damage. Even species particularly well adapted to ethanol consumption face detrimental effects when exposed to concentrations above 4%. Here, we investigated the metabolism of ethanol and its impact on survival and behavior in the Oriental hornet ( Vespa orien...
• Reconciling theories of dominance with the relative rates of adaptive substitution on sex chromosomes and autosomes AI翻译
  作者：McDonough, Yasmine; Ruzicka, Filip; Connallon, Tim
  作者单位：Monash University; Institute of Science & Technology - Austria
  摘要：The dominance of beneficial mutations is a key evolutionary parameter affecting the rate and genetic basis of adaptation, yet it is notoriously difficult to estimate. A leading method to infer it is to compare the relative rates of adaptive substitution for X- linked and autosomal genes, which-according to a classic model by Charlesworth et al. (1987)-is a simple function of the dominance of new beneficial mutations. Recent evidence that rates of adaptive substitution are faster for X- linked ...
• Maternal NO2 exposure and fetal growth restriction: Hypoxia transmission and lncRNAs- proinflammation- mediated abnormal hematopoiesis AI翻译
  作者：Qin, Liyao; Yue, Huifeng; Gong, Zhihua; Guo, Yuqiong; Li, Dan; Ma, Li; Yixi, Zhuoma; He, Jing; Li, Zhihong; Li, Guangke; Yan, Wei; Sang, Nan
  作者单位：Shanxi University; Shanxi Medical University; Xuzhou Medical University
  摘要：Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO2) exposure during the second trimester was positively associated with FGR, with an ad...