Breathing orchestrates synchronization of sleep oscillations in the human hippocampus

• 成果类型: Article
• 署名作者: Sheriff, Andrew; Zhou, Guangyu; Sagar, Vivek; Morgenthaler, Justin B.; Cyr, Christopher; Hauner, Katherina K.; Omidbeigi, Mahmoud; Rosenow, Joshua M.; Schuele, Stephan U.; Lane, Gregory; Zelano, Christina
• 署名单位: Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine; Northwestern University; Feinberg School of Medicine
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-11791
• DOI: 10.1073/pnas.2405395121
• 发表日期: 2024-12-24
• 关键词: theta-oscillations; memory function; olfactory-bulb; rhythm; respiration; frequency; ripples; neurons; sniff; DISCRIMINATION

摘要

Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory- driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep- related respiratory and memory processes.