2024

最新文章

• In-place molecular preservation of cellulose in 5,000-year-old archaeological textile (vol 117, pg 19670, 2020) AI翻译
  作者：Reynaud, Corentin; Thoury, Mathieu; Dazzi, Alexandre; Latour, Gael; Scheel, Mario; Li, Jiayi; Thomas, Ariane; Moulherat, Christophe; Didier, Aurore; Bertrand, Loic
• Instant welding of gels by dry chitosan interlayers AI翻译
  作者：Spencer, Nicholas D.
  作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich
• Lutetium texaphyrin: A photocatalyst that triggers pyroptosis via biomolecular photoredox catalysis AI翻译
  作者：Xu, Yunjie; Chau, Calvin, V; Lee, Jieun; Sedgwick, Adam C.; Yu, Le; Li, Mingle; Peng, Xiaojun; Kim, Jong Seung; Sessler, Jonathan L.
  作者单位：Korea University; University of Texas System; University of Texas Austin; Shenzhen University
  摘要：Photon- controlled pyroptosis activation (PhotoPyro) is a promising technique for cancer immunotherapy due to its noninvasive nature, precise control, and ease of operation. Here, we report that biomolecular photoredox catalysis in cells might be an important mechanism underlying PhotoPyro. Our findings reveal that the photocatalyst lutetium texaphyrin (MLu) facilitates rapid and direct photoredox oxidation of nicotinamide adenine dinucleotide, nicotinamide adenine dinucleotide phosphate, and ...
• Bio- catalyzed oxidation selfcharging zinc-polymer batteries AI翻译
  作者：Pan, Jun; Liu, Yanhong; Yang, Jian; Wu, Jiawen; Fan, Hong Jin
  作者单位：Nanyang Technological University; Shandong University
  摘要：Oxidation selfcharging batteries have emerged with the demand for powering electronic devices around the clock. The low efficiency of selfcharging has been the key challenge at present. Here, a more efficient autoxidation selfcharging mechanism is realized by introducing hemoglobin (Hb) as a positive electrode additive in the polyaniline (PANI) - zinc battery system. The heme acts as a catalyst that reduces the energy barrier of the autoxidation reaction by regulating the charge and spin state...
• Molecular basis for human aquaporin inhibition AI翻译
  作者：Huang, Peng; Abacka, Hannah; Wilson, Carter J.; Wind, Malene Lykke; Rutzler, Michael; Hagstroem-Andersson, Anna; Gourdon, Pontus; de Groot, Bert L.; Venskutonyte, Raminta; Lindkvist-Petersson, Karin
  作者单位：Lund University; University of Copenhagen; Lund University; Lund University
  摘要：Cancer invasion and metastasis are known to be potentiated by the expression of aquaporins (AQPs). Likewise, the expression levels of AQPs have been shown to be prognostic for survival in patients and have a role in tumor growth, edema, angiogenesis, and tumor cell migration. Thus, AQPs are key players in cancer biology and potential targets for drug development. Here, we present the single- particle cryo- EM structure of human AQP7 at 3.2- angstrom resolution in complex with the specific inhi...
• Unraveling the molecular mechanism for enhanced gas adsorption in mixed-metal MOFs via solid-state NMR spectroscopy AI翻译
  作者：Yan, Tao; Hou, Huaming; Wu, Changzong; Cai, Yuhang; Yin, Anping; Cao, Zhi; Liu, Zhong; He, Peng; Xu, Jun
  作者单位：Nankai University; Nankai University; Chinese Academy of Sciences; Institute of Coal Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Qinghai Institute of Salt Lakes, CAS
  摘要：The incorporation of multiple metal ions in metal-organic frameworks (MOFs) through one - pot synthesis can induce unique properties originating from specific atomic-scale spatial apportionment, but the extraction of this crucial information poses challenges. Herein, nondestructive solid-state NMR spectroscopy was used to discern the atomic-scale metal apportionment in a series of bulk Mg1-xCox-MOF-74 samples via identification and quantification of eight distinct arrangements of Mg/Co ions la...
• A macrophage- collagen fragment axis mediates subcutaneous adipose tissue remodeling in mice AI翻译
  作者：Vujicic, Milica; Broderick, Isabella; Salmantabar, Pegah; Perian, Charlene; Nilsson, Jonas; Wallem, Carina Sihlbom; Asterholm, Ingrid Wernstedt
  作者单位：University of Gothenburg; University of Gothenburg
  摘要：Efficient removal of fibrillar collagen is essential for adaptive subcutaneous adipose tissue (SAT) expansion that protects against ectopic lipid deposition during weight gain. Here, we used mice to further define the mechanism for this collagenolytic process. We show that loss of collagen type- 1 (CT1) and increased CT1-fragment levels in expanding SAT are associated with proliferation of resident M2- like macrophages that display increased CD206- mediated engagement in collagen endocytosis c...
• Targeted checkpoint control of B cells undergoing positive selection in germinal centers by follicular regulatory T cells AI翻译
  作者：Ke, Fang; Benet, Zachary L.; Shelyakin, Pavel; V. Britanova, Olga; Gupta, Neetu; Dent, Alexander L.; Moore, Bethany B.; Grigorova, Irina L.
  作者单位：Pirogov Russian National Research Medical University; Russian Academy of Sciences; Pushchino Scientific Center for Biological Research (PSCBI) of the Russian Academy of Sciences; Institute of Bioorganic Chemistry of the Russian Academy of Sciences; University of Kiel; Cleveland Clinic Foundation; Indiana University System; Indiana University Bloomington
  摘要：Follicular regulatory T cells (Tfr) can play opposite roles in the regulation of germinal center (GC) responses. Depending on the studies, Tfr suppress or support GC and B cell affinity maturation. However, which factors determine positive vs. negative effects of Tfr on the GC B cell is unclear. In this study, we show that GC centrocytes that express MYC up- regulate expression of CCL3 chemokine that is needed for both the positive and negative regulation of GC B cells by Tfr. B cell-intrinsic...
• HIV-1 capsid shape, orientation, and entropic elasticity regulate translocation into the nuclear pore complex AI翻译
  作者：Hudait, Arpa; Voth, Gregory A.
  作者单位：University of Chicago; University of Chicago
  摘要：Nuclear import and uncoating of the viral capsid are critical steps in the HIV - 1 life cycle that serve to transport and release genomic material into the nucleus. Viral core import involves translocating the HIV - 1 capsid at the nuclear pore complex (NPC). Notably, the central channel of the NPC appears to often accommodate and allow passage of intact HIV - 1 capsid, though mechanistic details of the process remain to be fully understood. Here, we investigate the molecular interactions that...
• Reverse transcriptase inhibitors prevent liver abscess formation during Escherichia coli bloodstream infection AI翻译
  作者：Hullahalli, Karthik; Dailey, Katherine G.; Hasegawa, Yuko; Johnson, Welkin E.; Waldor, Matthew K.
  作者单位：Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Boston College
  摘要：The presence of bacteria in the bloodstream is associated with severe clinical outcomes. In mice, intravenous inoculation of Escherichia coli can lead to the formation of macroscopic abscesses in the liver. Abscesses are regions of severe necrosis and consist of millions of bacteria surrounded by inflammatory immune cells. Liver abscess susceptibility varies widely across strains of mice, but the host factors governing this variation are unknown. Here, we profiled hepatic transcriptomes in mic...