Maternal NO2 exposure and fetal growth restriction: Hypoxia transmission and lncRNAs- proinflammation- mediated abnormal hematopoiesis

• 成果类型: Article
• 署名作者: Qin, Liyao; Yue, Huifeng; Gong, Zhihua; Guo, Yuqiong; Li, Dan; Ma, Li; Yixi, Zhuoma; He, Jing; Li, Zhihong; Li, Guangke; Yan, Wei; Sang, Nan
• 署名单位: Shanxi University; Shanxi Medical University; Xuzhou Medical University
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-8812
• DOI: 10.1073/pnas.2409597121
• 发表日期: 2024-10-29
• 关键词: adverse pregnancy outcomes; air-pollution exposure; nitrogen-dioxide; birth-weight; stem-cells; placenta; neurodevelopment; CONSEQUENCES; pathogenesis; association

摘要

Epidemiological studies show a strong correlation between air pollution and fetal growth restriction (FGR), but existing results are controversial due to inherent limitations, such as causality of specific pollutants, developmental origin, and maternal-fetal transmission. To address this controversy, we first conducted a retrospective analysis of 28,796 newborns and revealed that maternal nitrogen dioxide (NO2) exposure during the second trimester was positively associated with FGR, with an adjusted odds ratio of 1.075 (95% confidence interval: 1.020- 1.133) per 10 mu g/m3 NO2 increase for small for gestational age. Then, by establishing an animal model of prenatal NO2 exposure, we confirmed its adverse effects on embryonic growth and hematopoiesis in the yolk sac and fetal liver, primarily affecting the differentiation of hematopoietic stem and progenitor cells and erythroid maturation. maternal NO2 inhalation induced acquired methemoglobinemia through its byproducts and hypoxia- inducible factors, disturbed hematopoiesis through the hypoxia- inducible factor risk prevention and clinical intervention to promote child well- being in NO2- polluted areas.