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作者：Ma, Dingbang; Ojha, Pranav; Yu, Albert D.; Araujo, Maisa S.; Luo, Weifei; Keefer, Evelyn; Diaz, Madelen M.; Wu, Meilin; Joiner, William J.; Abruzzi, Katharine C.; Rosbash, Michael
作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Brandeis University; Howard Hughes Medical Institute; Brandeis University; Fundacao Oswaldo Cruz; Guangxi Academy of Sciences; University of Miami; University of California System; University of California San Diego; University of California System; University of California San Diego
摘要：To address the contribution oftranscriptional regulation to Drosophila clock gene expression and to behavior, we generated a series of CRISPR- mediated deletions within two regions of the circadian gene timeless (tim), an intronic E - box region and an upstream E - box region that are both recognized by the key transcription factor Clock (Clk) and its heterodimeric partner Cycle. The upstream deletions but not an intronic deletion dramatically impact tim expression in fly heads; the biggest up...
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作者：Ravindran, Sandeep
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作者：Scarpa, Almoro; Pianezza, Riccardo; Wierzbicki, Filip; Kofler, Robert
作者单位：University of Veterinary Medicine Vienna
摘要：Transposable element invasions have a profound impact on the evolution of genomes and phenotypes. It is thus an important open question how often such TE invasions occur. To address this question, we utilize the genomes of historical specimens, sampled about 200 y ago. We found that the LTR retrotransposons Blood, Opus, and 412spread in Drosophila melanogaster in the 19th century. These invasions constitute second waves, as degraded fragments were found for all three TEs. The composition of Op...
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作者：Wichman, Casey J.
作者单位：University System of Georgia; Georgia Institute of Technology; Resources for the Future
摘要：Visitation to National Parks in the United States increased by more than 25% since 2010, rising from roughly 70 to 90 million annual visitors. Anecdotes suggest that this increase was driven by the advent of social media in the early-to-mid 2010s, generating a new form of exposure for parks, and has led to concerns about overcrowding and degradation of environmental quality. However, there is little empirical evidence on the role of social media in influencing recreation decisions. Here, I con...
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作者：Hill, Tyler J.; Sengupta, Piali
作者单位：Brandeis University
摘要：Sensory adaptation allows neurons to adjust their sensitivity and responses based on recent experience. The mechanisms that mediate continuous adaptation to stimulus history over seconds- to hours-long timescales, and whether these mechanisms can operate within a single sensory neuron type, are unclear. The single pair of AFD thermosensory neurons in Caenorhabditis elegans exhibits experience- dependent plasticity in their temperature response thresholds on both minutes- and hours-long timesca...
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作者：Angell, Daniel K.; Li, Shuo; Utzat, Hendrik; Thurston, Matti L. S.; Liu, Yin; Dahl, Jeremy; Carlson, Robert; Shen, Zhi-Xun; Melosh, Nicholas; Sinclair, Robert; Dionne, Jennifer A.
作者单位：Stanford University; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University
摘要：Diamond color centers have proven to be versatile quantum emitters and exquisite sensors of stress, temperature, electric and magnetic fields, and biochemical processes. Among color centers, the silicon -vacancy (SiV-) defect exhibits high brightness, minimal phonon coupling, narrow optical linewidths, and high degrees of photon indistinguishability. Yet the creation of reliable and scalable SiV--based color centers has been hampered by heterogeneous emission, theorized to originate from surfa...
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作者：Aziz, Iram; Kayastha, Kanwal; Kaltwasser, Susann; Vonck, Janet; Welsch, Sonja; Murphy, Bonnie J.; Kahnt, Jorg; Wu, Di; Wagner, Tristan; Shima, Seigo; Ermler, Ulrich
作者单位：University of Punjab; Leiden University; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society; Max Planck Society
摘要：Methanogenic archaea inhabiting anaerobic environments play a crucial role in the global biogeochemical material cycle. The most universal electrogenic reaction of their methane- producing energy metabolism is catalyzed byN5- methyl- tetrahydromethanopterin: coenzyme M methyltransferase (MtrABCDEFGH), which couples the vectorial Na+ transport with a methyl transfer between the one- carbon carriers tetrahydromethanopterin and coenzyme M via a vitamin B12 derivative (cobamide) as prosthetic grou...
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作者：Jenniches, Laura; Michaux, Charlotte; Popella, Linda; Reichardt, Sarah; Vogel, Joerg; Westermann, Alexander J.; Barquist, Lars
作者单位：Helmholtz Association; Helmholtz-Center for Infection Research; University of Wurzburg; University of Wurzburg; University of Toronto; University Toronto Mississauga
摘要：RNA decay is a crucial mechanism for regulating gene expression in response to environmental stresses. In bacteria, RNA- binding proteins (RBPs) are known to be involved in posttranscriptional regulation, but their global impact on RNA half - lives has not been extensively studied. To shed light on the role of the major RBPs ProQ and CspC/E in maintaining RNA stability, we performed RNA sequencing of Salmonella enterica over a time course following treatment with the transcription initiation i...
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作者：Mizutani, Kosuke; Yoshida, Yuki; Nakanishi, Eita; Miyata, Yugo; Tokumoto, Shoko; Fuse, Hiroto; Gusev, Oleg; Kikuta, Shingo; Kikawada, Takahiro
作者单位：University of Tokyo; National Agriculture & Food Research Organization - Japan; Institute of Science Tokyo; Tokyo Medical & Dental University (TMDU); Juntendo University; Ibaraki University
摘要：Pv11 is the only animal cell line that, when preconditioned with a high concentration of trehalose, can be preserved in the dry state at room temperature for more than one year while retaining the ability to resume proliferation. This extreme desiccation tolerance is referred to as anhydrobiosis. Here, we identified a transporter that contributes to the recovery of Pv11 cells from anhydrobiosis. In general, the solute carrier 5 (SLC5)-type secondary active transporters cotransport Na+ and carb...
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作者：Tan, Liangcheng; Cheng, Hai; Li, Dong; Orozbaev, Rustam; Li, Yanzhen; Xu, Hai; Edwards, R. Lawrence; Song, Yougui; Ma, Le; Lin, Fangyuan; Sinha, Ashish; An, Zhisheng
作者单位：Chinese Academy of Sciences; Institute of Earth Environment, CAS; Xi'an Jiaotong University; Chang'an University; National Academy of Sciences of the Kyrgyz Republic (NAS KR); Tianjin University; University of Minnesota System; University of Minnesota Twin Cities; Beijing Normal University
摘要：Central Asia (CA) is one of the world's most significant arid regions, which is markedly impacted by global warming. A better understanding of the dynamical processes governing its Holocene climate variability is critical for a better understanding of possible future impacts of climate change in the region. To date, most of the existing CA paleoclimate records are from the summer precipitation-dominated eastern CA (ECA), with few records from the winter precipitation-dominated western CA (WCA)...
