2024

最新文章

• Activation of the proton- sensing GPCR, GPR65 on fibroblast- like synoviocytes contributes to inflammatory joint pain AI翻译
  作者：Pattison, Luke A.; Rickman, Rebecca H.; Hilton, Helen; Dannawi, Maya; Wijesinghe, Susanne N.; Ladds, Graham; Yang, Li, V; Jones, Simon W.; Smith, Ewan St John
  作者单位：University of Cambridge; University of Birmingham; University of North Carolina; East Carolina University
  摘要：Inflammation is associated with localized acidosis, however, attributing physiological and pathological roles to proton- sensitive receptors is challenging due to their diversity and widespread expression. Here, agonists of the proton- sensing GPCR, GPR65, were proton- induced signaling events and demonstrated selectivity for GPR65. BTB was used to show that GPR65 activation on fibroblast- like synoviocytes (FLS), cells that line synovial joints, results in the secretion of proinflammatory med...
• Identification of a depupylation regulator for an essential enzyme in Mycobacterium tuberculosis AI翻译
  作者：Kahne, Shoshanna C.; Yoo, Jin Hee; Chen, James; Nakedi, Kehilwe; Iyer, Lakshminarayan M.; Putzel, Gregory; Samhadaneh, Nora M.; Pironti, Alejandro; Aravind, L.; Ekiert, Damian C.; Bhabha, Gira; Rhee, Kyu Y.; Darwin, K. Heran
  作者单位：New York University; Cornell University; Weill Cornell Medicine; National Institutes of Health (NIH) - USA; NIH National Library of Medicine (NLM); Johns Hopkins University
  摘要：In Mycobacterium tuberculosis (Mtb), proteins that are posttranslationally modified with a prokaryotic ubiquitin-like protein (Pup) can be degraded by bacterial proteasomes. A single Pup-ligase and depupylase shape the pupylome, but the mechanisms regulating their substrate specificity are incompletely understood. Here, we identified a depupylation regulator, a protein called CoaX, through its copurification with the depupylase Dop. CoaX is a pseudopantothenate kinase that showed evidence of b...
• BCL2 regulates antibacterial autophagy in the intestinal epithelium AI翻译
  作者：Li, Yun; Bel, Shai; Benjamin, Jamaal L.; Ruhn, Kelly A.; Hassell, Brian; Behrendt, Cassie L.; Kuang, Zheng; Hooper, Lora, V
  作者单位：Bar Ilan University; University of Texas System; University of Texas Southwestern Medical Center; Carnegie Mellon University; University of Texas System; University of Texas Southwestern Medical Center; University of Texas System; University of Texas Southwestern Medical Center; Howard Hughes Medical Institute
  摘要：Autophagy is a key innate immune defense mechanism in intestinal epithelial cells. Bacterial invasion of epithelial cells activates antibacterial autophagy through a process that requires the innate immune adaptor protein MYD88, yet how MYD88 signaling connects to the autophagy machinery is unknown. Here, we show that the mouse intestriggers MYD88 signaling that regulates binding of the anti- autophagy factor B cell lymcomplex and releasing BECN1 to initiate autophagy. Mice with BCL2 phosphory...
• Urban environments increase generalization of hummingbird- plant networks across climate gradients AI翻译
  作者：Maruyama, Pietro Kiyoshi; Bosenbecker, Camila; Cardoso, Joao Custodio F.; Sonne, Jesper; Ballarin, Caio S.; Souza, Camila S.; Leguizamon, Johana; Lopes, Ariadna Valentina; Maglianesi, Maria A.; Otarola, Mauricio Fernandez; Parra, Juan L.; Pena, Joao Carlos; Ramirez-Burbano, Monica B.; Rodriguez-Flores, Claudia I.; Rech, Andre R.; Zanata, Thais B.; Acevedo-Quintero, Juan Fernando; Almeida, Gabriela; Anselmo, Pedro Amaral; Amorim, Felipe W.; Montoya-Arango, Sergio; Araujo, Andrea Cardoso; Araujo, Francielle Paulina de; Arizmendi, Maria del Coro; Brito, Lucilene; Castillo-Garcia, Alejandra; Cherutte, Amanda Graciela; Costa, Carolina Figueredo; Ferreira, Fernando Henrique Santos; Filho, Manoel Martins Dias; Frota, Angelica Vilas Boas da; Iepsen, Alice Scheer; Freitas, Leandro; Almeida, Ingrid Gabriela de; Gomes, Ana Caroline Silva; Hachuy-Filho, Leandro; Lara, Carlos; Lasprilla, Liliana Rosero; Llano, Julian; Nakamura, Vivian; Neto, Edvaldo Nunes; Nunes, Cristiane Estrela C.; Machado, Caio Graco; Maianne, Monique; Gomez, Oscar Marin-; Marquez-Luna, Ubaldo; Mendes, Ruara Soares; Mesa, Juan Guillermo; Oliveira, Rafael; Lima-Passos, Jeane; Pereira, Janayna Andreza S.; Restrepo-Gonzalez, Alejandro; Rigotto, Sarah Mendonca; Rodrigues, Bruno Magro; Rui, Ana Maria; Ruiz, Diana Betancur; Sandoval, Luis; Santana, Carina Araujo; Silva, Jessica Luiza S.; Silva, Larissa Lais; Santos, Vinicius Calda; Silva, Paulo Antonio; Vargas-Espinosa, Maria Cristina; Vitorino, Breno Dias; Wolowski, Marina; Sazima, Ivan; Sazima, Marlies; Dalsgaard, Bo; Vizentin-Bugoni, Jeferson; Oliveira, Paulo E.
  作者单位：Universidade Federal de Minas Gerais; Universidade Federal de Uberlandia; Universidade Federal de Ouro Preto; University of Copenhagen; Universidade Estadual Paulista; Universidade Estadual de Montes Claros; Universidad Pedagogica y Tecnologica de Colombia (UPTC); Universidade Federal de Pernambuco; Universidad Estatal a Distancia (UNED); Universidad Costa Rica; Universidad de Antioquia; Universidade Estadual Paulista; Corporacion Universitaria Minuto de Dios (UNIMINUTO); El Colegio de la Frontera Sur (ECOSUR); Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM); Universidade Federal de Mato Grosso; Universidad Nacional de Colombia; Universidad Nacional Autonoma de Mexico; Universidade Federal de Minas Gerais; Universidad Pontificia Bolivariana; Universidade Federal de Mato Grosso do Sul; Universidade Estadual do Rio Grande do Sul (UERGS); Universidade do Oeste Paulista; Universidade Estadual de Feira de Santana; Universidade Federal de Sao Carlos; Universidade do Estado de Mato Grosso; Universidade Federal de Pelotas; Universidade Federal de Pernambuco; Universidade Federal de Sao Paulo (UNIFESP); Universidad Pedagogica y Tecnologica de Colombia (UPTC); Universidade Federal de Mato Grosso do Sul; Universidade Federal de Sao Carlos; Universidade Federal de Sao Carlos; Universidade de Sao Paulo; Universidad del Quindio; Universidade Estadual do Rio Grande do Sul (UERGS); Universidade Federal do Parana; Universidade Federal do Parana; Universidade Federal de Alfenas; Universidade Federal de Alfenas; Universidade Estadual de Campinas; Universidade de Sao Paulo; Universidade Estadual de Campinas; University of Copenhagen; Universidade Federal do Rio Grande do Sul; Universidade Federal de Uberlandia
  摘要：Urbanization has reshaped the distribution of biodiversity on Earth, but we are only beginning to understand its effects on ecological communities. While urbanization may have homogenization effects strong enough to blur the large- scale patterns in interaction networks, urban community patterns may still be associated with climate gradients reflecting large- scale biogeographical processes. Using 103 hummingbird-plant mutualistic networks across continental Americas, including 176 hummingbird...
• The environmental and social opportunities of reducing sugar intake AI翻译
  作者：Shepon, Alon; Sun, Zhongxiao; Makov, Tamar; Behrens, Paul; Barrett, Christopher
  作者单位：Tel Aviv University; China Agricultural University; Ben-Gurion University of the Negev; University of Oxford; Leiden University; Leiden University - Excl LUMC
  摘要：Sugar is the largest agricultural crop by mass and has seen a rapid increase in consumption around the world. There are widespread public health efforts to curb sugar intake through targeted policies given its association with noncommunicable diseases. Although curbing sugar intake aligns with sustainable diets that meet essential environmental and health targets, such a shift may be challenging from a political economy perspective. Utilizing sugar for other purposes such as the production of ...
• Forward and backward modeling of cultural evolutionary processes AI翻译
  作者：Wakano, Joe Y.; Aoki, Kenichi
  作者单位：Meiji University; University of Tokyo
  摘要：Modern cultural evolution theory adopts a variety of concepts and methods developed in mathematical biology, in particular population genetics theory. In addition to forward- looking approaches such as two- locus models, backward- looking approaches such as coalescent theory, which describe ancestral states of the current population, have played an important role in population genetics. Here, we show how forward and backward approaches can be applied to two examples in cultural evolution. The ...
• Identification of FBLL1 as a neuron- specific RNA 2′- O- methyltransferase mediating neuronal differentiation AI翻译
  作者：Zhang, Deyu; Li, Bo; Xu, Henan; Li, Jingying; Ma, Chao; Ge, Wei; Lu, Congcong; Cao, Xuetao
  作者单位：Nankai University; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College
  摘要：2 '- O- methylation is one of the most prevalent RNA modifications found in different RNA types. However, the identities of enzymes participating in the transfer of methyl groups are not well defined. To date, fibrillarin (FBL) is the only known small nucleolar ribonucleoprotein (snoRNP) 2 '- O- methyltransferase. Whether other snoRNP 2 '- O- methyltransferases exist and their functions in targeting RNAs to determine cell differentiation and function need to be elucidated. Here, we identify FB...
• Targeted degradation of Pin1 by protein- destabilizing compounds AI翻译
  作者：Alboreggia, Giulia; Udompholkul, Parima; Rodriguez, Isaac; Blaha, Gregor; Pellecchia, Maurizio
  作者单位：University of California System; University of California Riverside; University of California System; University of California Riverside
  摘要：The concept of targeted protein degradation is at the forefront of modern drug discovery, which aims to eliminate disease- causing proteins using specific molecules. In this paper, we explored the idea to design protein degraders based on the section of ligands that cause protein destabilization, hence that facilitate the cellular breakdown of the target. Our studies present covalent agents targeting Pin1, a cis-trans prolyl isomerase that plays a crucial role in tumorigenesis. Our design stra...
• A magnetohydrodynamic mechanism for the formation of solar polar vortices AI翻译
  作者：Dikpati, Mausumi; Raphaldini, Breno; Mcintosh, Scott W.; Korsos, Marianna B.; Guerrero, Gustavo A.; Gilman, Peter A.
  作者单位：National Center Atmospheric Research (NCAR) - USA; University of Sheffield; Universidade Federal de Minas Gerais
  摘要：rocky planets to Jupiter- and Saturn- like gas giant planets. Very little is known about their existence or dynamics on the Sun. What should be expected near the Sun's pole for the upcoming solar multi- viewpoint and polar missions? Here, we report the magnetohydrodynamic (MHD) nonlinear simulations for the formation and evolution of solar polar vortices using a near- surface MHD shallow- water model. Our findings indicate that the rush to the poles, the migration of magnetic fields toward the...
• Arkypallidal neurons in the external globus pallidus can mediate inhibitory control by altering competition in the striatum AI翻译
  作者：Giossi, Cristina; Bahuguna, Jyotika; Rubin, Jonathan E.; Verstynen, Timothy; Vich, Catalina
  作者单位：Universitat de les Illes Balears; Universites de Strasbourg Etablissements Associes; Universite de Strasbourg; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Carnegie Mellon University; Carnegie Mellon University
  摘要：Reactive inhibitory control is crucial for survival. Traditionally, this control in mammals was attributed solely to the hyperdirect pathway, with cortical control signals flowing unidirectionally from the subthalamic nucleus (STN) to basal ganglia output regions. Yet recent findings have put this model into question, suggesting that the STN is assisted in stopping actions through ascending control signals to the striatum mediated by the external globus pallidus (GPe). Here, we investigate thi...