2024

最新文章

• Formation of human kinship structures depending on population size and cultural mutation rate AI翻译
  作者：Itao, Kenji; Kaneko, Kunihiko
  作者单位：University of Tokyo; RIKEN; Max Planck Society; University of Copenhagen; Niels Bohr Institute; University of Tokyo
  摘要：How does social complexity depend on population size and cultural transmission? Kinship structures in traditional societies provide a fundamental illustration, where cultural rules between clans determine people's marriage possibilities. Here, we propose a simple model of kinship interactions that considers kin and in-law cooperation and sexual rivalry. In this model, multiple societies compete. Societies consist of multiple families with different cultural traits and mating preferences. These...
• H3K14ac facilitates the reinstallation of constitutive heterochromatin in Drosophila early embryos by engaging Eggless/SetDB1 AI翻译
  作者：Tang, Ruijun; Zhou, Mengqi; Chen, Yuwei; Jiang, Zhenghui; Fan, Xunan; Zhang, Jingheng; Dong, Aiping; Lv, Lu; Mao, Song; Chen, Fang; Gao, Guanjun; Min, Jinrong; Liu, Ke; Yuan, Kai
  作者单位：Central South University; Central South University; Central China Normal University; University of Toronto; Structural Genomics Consortium; Central South University; ShanghaiTech University; Central South University
  摘要：Constitutive heterochromatin, a fundamental feature of eukaryotic nucleus essential for transposon silencing and genome stability, is rebuilt on various types of repetitive DNA in the zygotic genome during early embryogenesis. However, the molecular program underlying this process remains poorly understood. Here, we show that histone H3 lysine 14 acetylation (H3K14ac) is engaged in the reinstallation of constitutive heterochromatin in Drosophila early embryos. H3K14ac partially colocalizes wit...
• A randomized trial of behavioral interventions yielding sustained reductions in distracted driving AI翻译
  作者：Ebert, Jeffrey P.; Xiong, Ruiying A.; Khan, Neda; Abdel-Rahman, Dina; Leitner, Aaron; Everett, William C.; Gaba, Kristen L.; Fisher, William J.; Mcdonald, Catherine C.; Winston, Flaura K.; Rosin, Roy M.; Volpp, Kevin G.; Barnett, Ian J.; Wiebe, Douglas J.; Halpern, Scott D.; Delgado, Mucio Kit
  作者单位：University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; Pennsylvania Medicine; Childrens Hospital of Philadelphia; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Pennsylvania; University of Michigan System; University of Michigan
  摘要：Distracted driving is responsible for nearly 1 million crashes each year in the United States alone, and a major source of driver distraction is handheld phone use. We conducted a randomized, controlled trial to compare the effectiveness of interventions designed to create sustained reductions in handheld use while driving (NCT04587609). Participants were to 77 who averaged at least 2 min/h of handheld use while driving in the month prior to study invitation. They were randomly assigned to one...
• Huntingtin contains an ubiquitin- binding domain and regulates lysosomal targeting of mitochondrial and RNA- binding proteins AI翻译
  作者：Fote, Gianna M.; V. Eapen, Vinay; Lim, Ryan G.; Yu, Clinton; Salazar, Lisa; Mcclure, Nicolette R.; Mcknight, Jharrayne; Nguyen, Thai B.; Heath, Marie C.; Lau, Alice L.; Villamil, Mark A.; Miramontes, Ricardo; Kratter, Ian H.; Finkbeiner, Steven; Reidling, Jack C.; Paulo, Joao A.; Kaiser, Peter; Huang, Lan; Housman, David E.; Thompson, Leslie M.; Steffan, Joan S.
  作者单位：University of California System; University of California Irvine; University of California System; University of California Irvine; Harvard University; Harvard Medical School; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California Irvine; University of California System; University of California San Francisco; The J David Gladstone Institutes; Stanford University; University of California System; University of California San Francisco; University of California System; University of California San Francisco; Massachusetts Institute of Technology (MIT); University of California System; University of California Irvine
  摘要：Understanding the normal function of the Huntingtin (HTT) protein is of significance in the design and implementation of therapeutic strategies for Huntington's disease (HD). Expansion of the CAG repeat in the HTT gene, encoding an expanded polyglutamine (polyQ) repeat within the HTT protein, causes HD and may compromise HTT's normal activity contributing to HD pathology. Here, we investigated the previously defined role of HTT in autophagy specifically through studying HTT's association with ...
• Targeting the muscarinic M1 receptor with a selective, brain- penetrant antagonist to promote remyelination in multiple sclerosis (Publication with Expression of Concern. See vol. 122, 2025) AI翻译
  作者：Poon, Michael M.; Lorrain, Kym I.; Stebbins, Karin J.; Edu, Geraldine C.; Broadhead, Alexander R.; Lorenzana, Ariana J.; Roppe, Jeffrey R.; Baccei, Jill M.; Baccei, Christopher S.; Chen, Austin C.; Green, Ari J.; Lorrain, Daniel S.; Chan, Jonah R.
  作者单位：University of California System; University of California San Francisco
  摘要：Multiple sclerosis (MS) is a chronic and debilitating neurological disease that results in inflammatory demyelination. While endogenous remyelination helps to recover function, this restorative process tends to become less efficient over time. Currently, intense efforts aimed at the mechanisms that promote remyelination are being considered promising therapeutic approaches. The M1 muscarinic acetylcholine receptor (M1R) was previously identified as a negative regulator of oligodendrocyte diffe...
• Versatile, modular, and customizable magnetic solid- droplet systems AI翻译
  作者：Sun, Mengmeng; Wu, Yingdan; Zhang, Jianhua; Zhang, Hongchuan; Liu, Zemin; Li, Mingtong; Wang, Chunxiang; Sitti, Metin
  作者单位：Max Planck Society; Harbin Institute of Technology; Koc University; Koc University
  摘要：Magnetic miniature robotic systems have attracted broad research interest because of their precise maneuverability in confined spaces and adaptability to diverse environments, holding significant promise for applications in both industrial infrastructures and biomedical fields. However, the predominant construction methodology involves the preprogramming of magnetic components into the system's structure. While this approach allows for intricate shape transformations, it exhibits limited flexi...
• An IL-23-STAT4 pathway is required for the proinflammatory function of classical dendritic cells during CNS inflammation AI翻译
  作者：Alakhras, Nada S.; Zhang, Wenwu; Barros, Nicolas; Sharma, Anchal; Ropa, James; Priya, Raj; Yang, X. Frank; Kaplan, Mark H.
  作者单位：Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Indiana University System; Indiana University Bloomington; Eli Lilly
  摘要：Although many cytokine pathways are important for dendritic cell (DC) development, it is less clear what cytokine signals promote the function of mature dendritic cells. The signal transducer and activator of transcription 4 (STAT4) promotes protective immunity and autoimmunity downstream of proinflammatory cytokines including IL- 12 and IL- 23. In experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS), Stat4-/- mice are resistant to the development of infl...
• The structure and mechanics of the cell cortex depend on the location and adhesion state AI翻译
  作者：Flormann, D. A. D.; Kainka, L.; Montalvo, G.; Anton, C.; Rheinlaender, J.; Thalla, D.; Vesperini, D.; Pohland, M. O.; Kaub, K. H.; Schu, M.; Pezzano, F.; Ruprecht, V.; Terriac, E.; Hawkins, R. J.; Lautenschlaeger, F.
  作者单位：Saarland University; Eberhard Karls University of Tubingen; University of Gottingen; Barcelona Institute of Science & Technology; Pompeu Fabra University; Centre de Regulacio Genomica (CRG); Pompeu Fabra University; ICREA; University of Sheffield; Saarland University
  摘要：Cells exist in different phenotypes and can transition between them. A phenotype may be characterized by many different aspects. Here, we focus on the example of whether the cell is adhered or suspended and choose particular parameters related to the structure and mechanics of the actin cortex. The cortex is essential to cell mechanics, morphology, and function, such as for adhesion, migration, and division of animal cells. To predict and control cellular functions and prevent malfunctioning, ...
• Active interface bulging in Bacillus subtilis swarms promotes self-assembly and biofilm formation AI翻译
  作者：Liu, Siyu; Li, Ye; Xu, Haoran; Kearns, Daniel B.; Wu, Yilin
  作者单位：Chinese University of Hong Kong; Chinese Academy of Sciences; Shenzhen Institute of Advanced Technology, CAS; Indiana University System; Indiana University Bloomington
  摘要：Microbial communities such as biofilms are commonly found at interfaces. However, it is unclear how the physical environment of interfaces may contribute to the development and behavior of surface-associated microbial communities. Combining multimode imaging, single-cell tracking, and numerical simulations, here, we found that activity-induced interface bulging promotes colony biofilm formation in Bacillus subtilis swarms presumably via segregation and enrichment of sessile cells in the bulgin...
• Overlooked significance of iodic acid in new particle formation in the continental atmosphere AI翻译
  作者：Ning, An; Shen, Jiewen; Zhao, Bin; Wang, Shuxiao; Cai, Runlong; Jiang, Jingkun; Yan, Chao; Fu, Xiao; Zhang, Yunhong; Li, Jing; Ouyang, Daiwei; Sun, Yisheng; Saiz-Lopez, Alfonso; Francisco, Joseph S.; Zhang, Xiuhui
  作者单位：Beijing Institute of Technology; Tsinghua University; Beijing University of Chemical Technology; Nanjing University; Tsinghua University; Tsinghua Shenzhen International Graduate School; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); University of Pennsylvania; University of Pennsylvania
  摘要：New particle formation (NPF) substantially affects the global radiation balance and climate. Iodic acid (IA) is a key marine NPF driver that recently has also been detected inland. However, its impact on continental particle nucleation remains unclear. Here, we provide molecular- level evidence that IA greatly facilitates clustering of two typical land- based nucleating precursors: dimethylamine (DMA) and sulfuric acid (SA), thereby enhancing particle nucleation. Incorporating this mechanism i...