2024

最新文章

• Genomic ancestry and social dynamics of the last hunter- gatherers of Atlantic France AI翻译
  作者：Simoes, Luciana G.; Stjerna, Rita Peyroteo-; Marchand, Gregor; Bernhardsson, Carolina; Vialet, Amelie; Chetty, Darshan; Alacamli, Erkin; Edlund, Hanna; Bouquin, Denis; Dina, Christian; Garmond, Nicolas; Gunther, Torsten; Jakobsson, Mattias
  作者单位：Uppsala University; University of Gothenburg; Linnaeus University; Universidade de Lisboa; Centre National de la Recherche Scientifique (CNRS); Universite de Rennes; Museum National d'Histoire Naturelle (MNHN); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Texas A&M University System; Texas A&M University College Station; Universite Bourgogne Europe; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Humanities & Social Sciences (INSHS); Nantes Universite; CHU de Nantes; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS)
  摘要：Since the early Holocene, western and central Europe was inhabited by a genetically distinct group of Western Hunter- Gatherers (WHGs). This group was eventually replaced and assimilated by the incoming Neolithic farmers. The western Atlantic fa & ccedil;ade was home to some of the last Mesolithic sites of mainland Europe, represented by the iconic open - air sites at Hoedic and T & eacute;viec in southern Brittany, France. These sites are known for the unusually well- preserved and rich buria...
• The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid- mediated subunit contacts in mechanosensory transduction AI翻译
  作者：Clark, Sarah; Jeong, Hanbin; Posert, Rich; Goehring, April; Gouaux, Eric
  作者单位：Oregon Health & Science University; Oregon Health & Science University
  摘要：Mechanotransduction is the process by which a mechanical force, such as touch, is converted into an electrical signal. Transmembrane channel - like (TMC) proteins are an evolutionarily conserved family of membrane proteins whose function has been linked to a variety of mechanosensory processes, including hearing and balance sensation in vertebrates and locomotion in Drosophila. TMC1 and TMC2 are components of ion channel complexes, but the molecular features that tune these complexes to divers...
• S1 basic leucine zipper transcription factors shape plant architecture by controlling C/N partitioning to apical and lateral organs AI翻译
  作者：Kreisz, Philipp; Hellens, Alicia M.; Froeschel, Christian; Krischke, Markus; Maag, Daniel; Feil, Regina; Wildenhain, Theresa; Draken, Jan; Braune, Gabriel; Erdelitsch, Leon; Cecchino, Laura; Wagner, Tobias C.; Ache, Peter; Mueller, Martin J.; Becker, Dirk; Lunn, John E.; Hanson, Johannes; Beveridge, Christine A.; Fichtner, Franziska; Barbier, Francois F.; Weiste, Christoph
  作者单位：University of Wurzburg; University of Queensland; University of Queensland; Max Planck Society; University of Wurzburg; Umea University; Heinrich Heine University Dusseldorf; Centre National de la Recherche Scientifique (CNRS); Universite de Montpellier; INRAE
  摘要：Plants tightly control growth of their lateral organs, which led to the concept of apical dominance. However, outgrowth of the dormant lateral primordia is sensitive to the plant's nutritional status, resulting in an immense plasticity in plant architecture. While the impact of hormonal regulation on apical dominance is well characterized, the prime importance of sugar signaling to unleash lateral organ formation has just recently emerged. Here, we aimed to identify transcriptional regulators,...
• A biochemical description of postsynaptic plasticity-with timescales ranging from milliseconds to seconds AI翻译
  作者：Li, Guanchun; McLaughlin, David W.; Peskin, Charles S.
  作者单位：New York University; New York University; New York University; New York University; NYU Shanghai; NYU Langone Medical Center; New York University; Howard Hughes Medical Institute; Baylor College of Medicine
  摘要：Synaptic plasticity [long-term potentiation/depression (LTP/D)], is a cellular mechanism underlying learning. Two distinct types of early LTP/D (E-LTP/D), acting on very different time scales, have been observed experimentally-spike timing dependent plasticity (STDP), on time scales of tens of ms; and behavioral time scale synaptic plasticity (BTSP), on time scales of seconds. BTSP is a candidate for a mechanism underlying rapid learning of spatial location by place cells. Here, a computationa...
• The shape of Nature's stingers revealed AI翻译
  作者：Quan, Haocheng; Liang, Xudong; Zhang, Xuan; Meyers, Marc A.; Mcmeeking, Robert M.; Arzt, Eduard
  作者单位：Nanjing University; Leibniz Association; Leibniz Institut fur Neue Materialien (INM); Harbin Institute of Technology; Peking University; University of California System; University of California San Diego; University of California System; University of California Santa Barbara; University of California System; University of California Santa Barbara; Saarland University; University of California System; University of California San Diego
  摘要：Stinger - like structures in living organisms evolved convergently across taxa for both defensive and offensive purposes, with the main goal being penetration and damage. Our observations over a broad range of taxa and sizes, from microscopic radiolarians to narwhals, reveal a self- similar geometry of the stinger extremity: the diameter (d) increases along the distance from the tip (x) following a power law x similar to dn, with the tapering exponent varying universally between 2 and 3. We de...
• RIPK1 activation in Mecp2-deficient microglia promotes inflammation and glutamate release in RTT AI翻译
  作者：Cao, Ze; Min, Xia; Xie, Xingxing; Huang, Maoqing; Liu, Yingying; Sun, Weimin; Xu, Guifang; He, Miao; He, Kaiwen; Li, Ying; Yuan, Junying
  作者单位：Chinese Academy of Sciences; Shanghai Institute of Organic Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Fudan University; Fudan University
  摘要：Rett syndrome (RTT) is a devastating neurodevelopmental disorder primarily caused by mutations in the methyl-CpG binding protein 2 (Mecp2) gene. Here, we found that inhibition of Receptor- Interacting Serine/Threonine- Protein Kinase 1 (RIPK1) kinase ameliorated progression of motor dysfunction after onset and prolonged the survival of Mecp2-null mice. Microglia were activated early in myeloid Mecp2- deficient mice, which was inhibited upon inactivation of RIPK1 kinase. RIPK1 inhibition in Mec...
• Flexible B12 ecophysiology of Phaeocystis antarctica due to a fusion B12-independent methionine synthase with widespread homologues AI翻译
  作者：Rao, Deepa; Fussy, Zoltan; Brisbin, Margaret M.; McIlvin, Matthew R.; Moran, Dawn M.; Allen, Andrew E.; Follows, Michael J.; Saito, MakA.
  作者单位：Massachusetts Institute of Technology (MIT); J. Craig Venter Institute; University of California System; University of California San Diego; Scripps Institution of Oceanography
  摘要：Coastal Antarctic marine ecosystems are significant in carbon cycling because of their intense seasonal phytoplankton blooms. Southern Ocean algae are primarily limited by light and iron (Fe) and can be co -limited by cobalamin (vitamin B12). Micronutrient limitation controls productivity and shapes the composition of blooms which are typically dominated by either diatoms or the haptophyte Phaeocystis antarctica. However, the vitamin requirements and ecophysiology of the keystone species P. an...
• Discovery of lirafugratinib (RLY-4008), a highly selective irreversible small-molecule inhibitor of FGFR2 AI翻译
  作者：Schonherr, Heike; Ayaz, Pelin; Taylor, Alexander M.; Casaletto, Jessica B.; Toure, B. Barry; Moustakas, Demetri T.; Hudson, Brandi M.; Valverde, Roberto; Zhao, Songping; O'Hearn, Patrick J.; Foster, Lindsey; Sharon, Dina A.; Garfinkle, Sam; Giordanetto, Fabrizio; Lescarbeau, Andre; Kurukulasuriya, Ravi; Gerami-Moayed, Nastaran; Maglic, Dejan; Bruderek, Kamil; Naik, Gaauri; Gunaydin, Hakan; Mader, Mary M.; Boezio, Alessandro A.; McLean, Thomas H.; Chen, Rongfeng; Wang, Yanxia; Shaw, David E.; Watters, James; Bergstrom, Donald A.
  作者单位：D. E. Shaw Research; Columbia University
  摘要：Fibroblast growth factor receptor (FGFR) kinase inhibitors have been shown to be effective in the treatment of intrahepatic cholangiocarcinoma and other advanced solid tumors harboring FGFR2 alterations, but the toxicity of these drugs frequently leads to dose reduction or interruption of treatment such that maximum efficacy cannot be achieved. The most common adverse effects are hyperphosphatemia caused by FGFR1 inhibition and diarrhea due to FGFR4 inhibition, as current therapies are not sel...
• Extraislet expression of islet antigen boosts T cell exhaustion to partially prevent autoimmune diabetes AI翻译
  作者：Selck, Claudia; Jhala, Gaurang; De George, David J.; Kwong, Chun-Ting J.; Christensen, Marie K.; Pappas, Evan G.; Liu, Xin; Ge, Tingting; Trivedi, Prerak; Kallies, Axel; Thomas, Helen E.; Kay, Thomas W. H.; Krishnamurthy, Balasubramanian
  作者单位：St. Vincent's Institute of Medical Research; University of Melbourne; NSW Health; St Vincents Hospital Sydney; St Vincent's Health; St Vincent's Hospital Melbourne; University of Melbourne; Peter Doherty Institute
  摘要：Persistent antigen exposure results in the differentiation of functionally impaired, also termed exhausted, T cells which are maintained by a distinct population of precursors of exhausted T (TPEX) cells. T cell exhaustion is well studied in the context of chronic viral infections and cancer, but it is unclear whether and how antigen- driven T cell exhaustion controls progression of autoimmune diabetes and whether this process can be harnessed to prevent diabetes. Using nonobese diabetic (NOD)...
• Excess natural- cause mortality in US counties and its association with reported COVID-19 deaths AI翻译
  作者：Paglino, Eugenio; Lundberg, Dielle J.; Wrigley-Field, Elizabeth; Zhou, Zhenwei; Wasserman, Joe A.; Raquib, Rafeya; Chen, Yea-Hung; Hempstead, Katherine; Preston, Samuel H.; Elo, Irma T.; Glymour, M. Maria; Stokes, Andrew C.
  作者单位：University of Pennsylvania; University of Pennsylvania; Boston University; University of Washington; University of Washington Seattle; University of Minnesota System; University of Minnesota Twin Cities; University of Minnesota System; University of Minnesota Twin Cities; Boston University; Research Triangle Institute; University of California System; University of California San Francisco; Robert Wood Johnson Foundation (RWJF); Boston University
  摘要：In the United States, estimates of excess deaths attributable to the COVID-19 pandemic have consistently surpassed reported COVID-19 death counts. Excess deaths reported to non- COVID-19 natural causes may represent unrecognized COVID-19 deaths, deaths caused by pandemic health care interruptions, and/or deaths from the pandemic's socioeconomic impacts. The geographic and temporal distribution of these deaths may help to evaluate which explanation is most plausible. We developed a Bayesian hie...