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作者：Guzikowski, Natalie J.; Kavalali, Ege T.
作者单位：Vanderbilt University; Vanderbilt University
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作者：Win, Poe Ei Phyu; Yang, Jiahui; Ning, Shuwang; Huang, Xiang; Fu, Gengtao; Sun, Qiming; Xia, Xing - Hua; Wang, Jiong
作者单位：Soochow University - China; Nanjing Normal University; Southern University of Science & Technology; Soochow University - China; Nanjing University
摘要：Developing cost- effective and high- performance electrocatalysts for oxygen reduction reaction (ORR) is critical for clean energy generation. Here, we propose an approach to the synthesis of iron phthalocyanine nanotubes (FePc NTs) as a highly active and selective electrocatalyst for ORR. The performance is significantly superior to FePc in randomly aggregated and molecularly dispersed states, as well as the commercial Pt/C catalyst. When FePc NTs are anchored on graphene, the resulting archi...
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作者：Xu, Na; Jiang, Xiaoyan; Zhang, Wenting; Shi, Yejie; Leak, Rehana K.; Keep, Richard F.; Ye, Qing; Yang, Tuo; Li, Sicheng; Hu, Xiaoming; Stetler, R. Anne; Bennett, Michael V. L.; Chen, Jun
作者单位：Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; Pennsylvania Commonwealth System of Higher Education (PCSHE); University of Pittsburgh; US Department of Veterans Affairs; Veterans Health Administration (VHA); VA Pittsburgh Healthcare System; Geriatric Research Education & Clinical Center; Duquesne University; University of Michigan System; University of Michigan; Yeshiva University; Montefiore Medical Center; Albert Einstein College of Medicine
摘要：The endothelial lining of cerebral microvessels is damaged relatively early after cerebral ischemia/reperfusion (I/R) injury and mediates blood-brain barrier (BBB) disruption, neurovascular injury, and long - term neurological deficits. I/R induces BBB leakage within 1 h due to subtle structural alterations in endothelial cells (ECs), including reorganization of the actin cytoskeleton and subcellular redistribution of junctional proteins. Herein, we show that the protein peroxiredoxin-4 (Prx4)...
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作者：Yu, Yingying; Su, Yang; Wang, Guoxiao; Lan, Miaomiao; Liu, Jin; Martin, Ruben Garcia; Brandao, Bruna Brasil; Lino, Marsel; Li, Lei; Liu, Chang; Kahn, C. Ronald; Meng, Qingyong
作者单位：China Agricultural University; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Joslin Diabetes Center, Inc.; Army Medical University
摘要：Muscle regeneration is a complex process relying on precise teamwork between multiple cell types, including muscle stem cells (MuSCs) and fibroadipogenic progenitors (FAPs). FAPs are also the main source of intramuscular adipose tissue (IMAT). Muscles without FAPs exhibit decreased IMAT infiltration but also deficient muscle regeneration, indicating the importance of FAPs in the repair process. Here, we demonstrate the presence of bidirectional crosstalk between FAPs and MuSCs via their secret...
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作者：[Anonymous]
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作者：El Mammeri, Nadia; Dregni, Aurelio J.; Duan, Pu; Hong, Mei
作者单位：Massachusetts Institute of Technology (MIT)
摘要：The microtubule- associated protein tau aggregates into amyloid fibrils in Alzheimer's disease and other neurodegenerative diseases. In these tauopathies, tau is hyperphosphorylated, suggesting that this posttranslational modification (PTM) may induce tau aggregation. Tau is also phosphorylated in normal developing brains. To investigate how tau phosphorylation induces amyloid fibrils, here we report the atomic structures of two phosphomimetic full- length tau fibrils assembled without anionic...
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作者：Eldeeb, Mohamed A.; Bayne, Andrew N.; Fallahi, Armaan; Goiran, Thomas; Macdougall, Emma J.; Soumbasis, Andrea; Zorca, Cornelia E.; Tabah, Jace-Jones; Thomas, Rhalena A.; Karpilovsky, Nathan; Mathur, Meghna; Durcan, Thomas M.; Trempe, Jean-Francois; Fon, Edward A.
作者单位：McGill University; McGill University; McGill University; McGill University
摘要：Mutations in PTEN- induced putative kinase 1 (PINK1) cause autosomal recessive early - onset Parkinson's disease (PD). PINK1 is a Ser/Thr kinase that regulates mitochondrial quality control by triggering mitophagy mediated by the ubiquitin (Ub) ligase Parkin. Upon mitochondrial damage, PINK1 accumulates on the outer mitochondrial membrane forming a high- molecular- weight complex with the translocase of the outer membrane (TOM). PINK1 then phosphorylates Ub, which enables recruitment and activ...
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作者：Groves, Ian J.; Matthews, Stephen M.; O'Connor, Christine M.
作者单位：Cleveland Clinic Foundation; Cleveland Clinic Foundation; University System of Ohio; Case Western Reserve University; University System of Ohio; Case Western Reserve University
摘要：Human cytomegalovirus (HCMV) is a prevalent pathogen that establishes life - long latent infection in hematopoietic cells. While this infection is usually asymptomatic, immune dysregulation leads to viral reactivation, which can cause significant morbidity and mortality. However, the mechanisms underpinning reactivation remain incompletely understood. The HCMV major immediate early promoter (MIEP)/enhancer is a key factor in this process, as its transactivation from a repressed to active state...
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作者：Tal, Alexey; Bischoff, Thomas; Pasquarello, Alfredo
作者单位：Swiss Federal Institutes of Technology Domain; Ecole Polytechnique Federale de Lausanne
摘要：We demonstrate the importance of addressing the F vertex and thus going beyond the GW approximation for achieving the energy levels of liquid water in manybody perturbation theory. In particular, we consider an effective vertex function in both the polarizability and the self -energy, which does not produce any computational overhead compared with the GW approximation. We yield the band gap, the ionization potential, and the electron affinity in good agreement with experiment and with a hybrid...
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作者：Neder, Izhar; Sirote-Katz, Chaviva; Geva, Meital; Lahini, Yoav; Ilan, Roni; Shokef, Yair
作者单位：Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv University; Tel Aviv University; Hiroshima University
摘要：We experimentally and theoretically study the dynamics of a one-dimensional array of pendula with a mild spatial gradient in their self -frequency and where neighboring pendula are connected with weak and alternating coupling. We map their dynamics to the topological Su-Schrieffer-Heeger model of charged quantum particles on a lattice with alternating hopping rates in an external electric field. By directly tracking the dynamics of a wave -packet in the bulk of the lattice, we observe Bloch os...
