2024

最新文章

• Reply to Vogt et al.: What does it mean that a phenomenon generalizes? AI翻译
  作者：Mazar, Nina; Elbaek, Christian T.; Mitkidis, Panagiotis
  作者单位：Boston University; Aarhus University
• Impact of repeated blast exposure on active- duty United States Special Operations Forces AI翻译
  作者：Gilmore, Natalie; Tseng, Chieh- En J.; Maffei, Chiara; Tromly, Samantha L.; Deary, Katryna B.; Mckinney, Isabella R.; Kelemen, Jessica N.; Healy, Brian C.; Hu, Collin G.; Llorden, Gabriel Ramos -; Masood, Maryam; Cali, Ryan J.; Guo, Jennifer; Belanger, Heather G.; Yao, Eveline F.; Baxter, Timothy; Fischl, Bruce; Foulkes, Andrea S.; Polimeni, Jonathan R.; Rosen, Bruce R.; Perl, Daniel P.; Hooker, Jacob M.; Zuercher, Nicole R.; Huang, Susie Y.; Kimberly, W. Taylor; Greve, Douglas N.; Donald, Christine L. Mac; O'Connor, Kristen Dams -; Bodien, Yelena G.; Abc, Brian L. Edlow
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; State University System of Florida; University of South Florida; Harvard University; Harvard T.H. Chan School of Public Health; Uniformed Services University of the Health Sciences - USA; State University System of Florida; University of South Florida; Uniformed Services University of the Health Sciences - USA; University of Washington; University of Washington Seattle; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Spaulding Rehabilitation Hospital
  摘要：United States (US) Special Operations Forces (SOF) are frequently exposed to explosive brain health are incompletely understood. Furthermore, there is no diagnostic test to detect brain injury from RBE. As a result, SOF personnel may experience cognitive, physical, and psychological symptoms for which the cause is never identified, and they may return to training or combat during a period of brain vulnerability. In 30 active- duty US SOF, we assessed the relationship between cumulative blast e...
• Bonding in tellurides AI翻译
  作者：Lee, Tae Hoon; Elliott, Stephen
  作者单位：Kyungpook National University (KNU); University of Oxford
• The tRNAVal half: A strong endogenous Toll- like receptor 7 ligand with a 5′- terminal universal sequence signature AI翻译
  作者：Pawar, Kamlesh; Kawamura, Takuya; Kirino, Yohei
  作者单位：Thomas Jefferson University
  摘要：Toll - like receptors (TLRs) are crucial components of the innate immune system. Endosomal TLR7 recognizes single - stranded RNAs, yet its endogenous ssRNA ligands are not fully understood. We previously showed that extracellular (ex - ) 5 '- half molecules of tRNA HisGUG (the 5 '- tRNA HisGUG half) in extracellular vesicles (EVs) of human macrophages activate TLR7 when delivered into endosomes of recipient macrophages. Here, we fully explored immunostimulatory ex - 5 '- tRNA half molecules an...
• Reply to Lee and Elliott: Changes of bonding upon crystallization in phase change materials AI翻译
  作者：Raty, Jean Yves; Bichara, Christophe; Schoen, Carl Friedrich; Gatti, Carlo; Wuttig, Matthias
  作者单位：University of Liege; Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Physics (INP); RWTH Aachen University; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Tecnologie Chimiche Giulio Natta (SCITEC-CNR); Helmholtz Association; Research Center Julich
• Modular multi- degree- of- freedom soft origami robots with reprogrammable electrothermal actuation AI翻译
  作者：Wu, Shuang; Zhao, Tuo; Zhu, Yong; Paulino, Glaucio H.
  作者单位：North Carolina State University; Princeton University; Princeton University
  摘要：Soft robots often draw inspiration from nature to navigate different environments. Although the inching motion and crawling motion of caterpillars have been widely studied in the design of soft robots, the steering motion with local bending control remains challenging. To address this challenge, we explore modular origami units which constitute building blocks for mimicking the segmented caterpillar body. Based on this concept, we report a modular soft Kresling origami crawling robot enabled b...
• Engineered polymer nanoparticles as artificial chaperones facilitating the selective refolding of denatured enzymes AI翻译
  作者：Li, Yan; Yin, Deping; Lee, Sang Yup; Lv, Yongqin
  作者单位：Beijing University of Chemical Technology; Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST); Korea Advanced Institute of Science & Technology (KAIST)
  摘要：Molecular chaperones assist in protein refolding by selectively binding to proteins in their nonnative states. Despite progress in creating artificial chaperones, these designs often have a limited range of substrates they can work with. In this paper, we present molecularly imprinted flexible polymer nanoparticles (nanoMIPs) designed as customizable biomimetic chaperones. We used model proteins such as cytochrome c, laccase, and lipase to screen polymeric monomers and identify the most effect...
• Limits of economy and fidelity for programmable assembly of size-controlled triply periodic polyhedra AI翻译
  作者：Duque, Carlos M.; Hall, Douglas M.; Tyukodi, Botond; Hagan, Michael F.; Santangelo, Christian D.; Grason, Gregory M.
  作者单位：Max Planck Society; University of Massachusetts System; University of Massachusetts Amherst; University of Massachusetts System; University of Massachusetts Amherst; Babes Bolyai University from Cluj; Brandeis University; Syracuse University
  摘要：We propose and investigate an extension of the Caspar-Klug symmetry principles for viral capsid assembly to the programmable assembly of size -controlled triply periodic polyhedra, discrete variants of the Primitive, Diamond, and Gyroid cubic minimal surfaces. Inspired by a recent class of programmable DNA origami colloids, we demonstrate that the economy of design in these crystalline assemblies-in terms of the growth of the number of distinct particle species required with the increased size...
• PARP1 UFMylation ensures the stability of stalled replication forks AI翻译
  作者：Gong, Yamin; Wang, Zhifeng; Zong, Wen; Shi, Ruifeng; Sun, Wenli; Wang, Sijia; Peng, Bin; Takeda, Shunichi; Wang, Zhao-Qi; Xu, Xingzhi
  作者单位：Shenzhen University; Leibniz Association; Leibniz Institut fur Alternsforschung - Fritz-Lipmann-Institut (FLI); Shandong University; Friedrich Schiller University of Jena
  摘要：The S - phase checkpoint involving CHK1 is essential for fork stability in response to fork stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation. However, it is unclear how the activity of PARP1 is regulated. Here, we found that UFMylation is required for the efficient activation of CHK1 by UFMylating PARP1 at K548 during replication stress. Inactivation of UFL1, the E3 enzyme essential for UFMylation, delayed CHK1 activation and inhibits nascent DNA degra...
• Plasmid partitioning driven by collective migration of ParA between nucleoid lobes AI翻译
  作者：Koehler, Robin; Murray, Sean M.
  摘要：The ParABS system is crucial for the faithful segregation and inheritance of many bacterial chromosomes and low - copy - number plasmids. However, despite extensive research, the spatiotemporal dynamics of the ATPase ParA and its connection to the dynamics and positioning of the ParB - coated cargo have remained unclear. In this study, we utilize high - throughput imaging, quantitative data analysis, and computational modeling to explore the in vivo dynamics of ParA and its interaction with Pa...