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作者：Dudley, Jessica S.; Renfree, Marilyn B.; Wagner, Guenter P.; Griffith, Oliver W.
作者单位：Macquarie University; University of Melbourne; Yale University; Yale University; University of Vienna
摘要：In the first live- bearing mammals, pregnancy was likely short and ended with a brief period of inflammatory maternal-fetal interaction. This mode of reproduction has been retained in many marsupials. While inflammation is key to successful implantation in eutherians, a key innovation in eutherians is the ability to switch off this inflammation after it has been initiated. This extended period, in which inflammation is suppressed, likely allowed for an extended period of placentation. Extended...
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作者：Chen, Ze- Ka; Quintanilla, Luis; Su, Yijing; Sheehy, Ryan N.; Simon, Jeremy M.; Luo, Yan-Jia; Li, Ya- Dong; Chen, Zhe; Asrican, Brent; Tart, Dalton S.; Farmer, W. Todd; Ming, Guo-Li; Song, Hongjun; Song, Juan
作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; University of Pennsylvania; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
摘要：Cholinergic neurons in the basal forebrain play a crucial role in regulating adult hippocampal neurogenesis (AHN). However, the circuit and molecular mechanisms underlying cholinergic modulation of AHN, especially the initial stages of this process related to the generation of newborn progeny from quiescent radial neural stem cells (rNSCs), remain unclear. Here, we report that stimulation of the cholinergic circuits projected from the diagonal band of Broca (DB) to the dentate gyrus (DG) neuro...
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作者：Yuzu, Keisuke; Lin, Ching - Yang; Yi, Po - Wei; Huang, Chih - Hao; Masuhara, Hiroshi; Chatani, Eri
作者单位：Kobe University; National Yang Ming Chiao Tung University
摘要：Liquid- like protein condensates have recently attracted much attention due to their critical roles in biological phenomena. They typically show high fluidity and reversibility for exhibiting biological functions, while occasionally serving as sites for the formation of amyloid fibrils. To comprehend the properties of protein condensates that underlie biological function and pathogenesis, it is crucial to study them at the single- condensate level; however, this is currently challenging due to...
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作者：Corrigan, Neva M.; Rokem, Ariel; Kuhl, Patricia K.
作者单位：University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle
摘要：Adolescence is a period of substantial social-emotional development, accompanied by dramatic changes to brain structure and function. Social isolation due to lockdowns that were imposed because of the COVID- 19 pandemic had a detrimental impact on adolescent mental health, with the mental health of females more affected than males. We assessed the impact of the COVID- 19 pandemic lockdowns on adolescent brain structure with a focus on sex differences. We collected MRI structural data longitudi...
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作者：Gaffney, Kristen A.; Guo, Ruiqiong; Bridges, Michael D.; Muhammednazaar, Shaima; Chen, Daoyang; Kim, Miyeon; Yang, Zhongyu; Schilmiller, Anthony L.; Faruk, Nabil F.; Peng, Xiangda; Jones, A. Daniel; Kim, Kelly H.; Sun, Liangliang; Hubbell, Wayne L.; Sosnick, Tobin R.; Hong, Heedeok
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作者：Veller, Carl; Przeworski, Molly; Coop, Graham
作者单位：University of Chicago; Columbia University; Columbia University; University of California System; University of California Davis; University of California System; University of California Davis
摘要：Family-based genome-wide association studies (GWASs) are often claimed to provide an unbiased estimate of the average causal effects (or average treatment effects; ATEs) of alleles, on the basis of an analogy between the random transmission of alleles from parents to children and a randomized controlled trial. We show that this claim does not hold in general. Because Mendelian segregation only randomizes alleles among children of heterozygotes, the effects of alleles in the children of homozyg...
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作者：Langlois, Jill
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作者：Nair, Prashant
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作者：He, Wenguang; Seabrook, Genevieve M. C. Gasmi; Ikura, Mitsuhiko; Lee, Jeffrey E.; Ohh, Michael
作者单位：University of Toronto; University of Toronto; University Health Network Toronto; Princess Margaret Cancer Centre; University of Toronto; University of Toronto
摘要：Prolyl- hydroxylation is an oxygen- dependent posttranslational modification (PTM) that is known to regulate fibril formation of collagenous proteins and modulate cellular expression of hypoxia- inducible factor (HIF) alpha subunits. However, our understanding of this important but relatively rare PTM has remained incomplete due to the lack of biophysical methodologies that can directly measure multiple prolyl- hydroxylation events within intrinsically disordered proteins. Here, we describe a ...
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作者：Hu, Xi-Le; Gan, Hui-Qi; Gui, Wen-Zhen; Yan, Kai-Cheng; Sessler, Jonathan L.; Yi, Dong; Tian, He; He, Xiao-Peng
作者单位：East China University of Science & Technology; East China University of Science & Technology; Naval Medical University; University of Bath; University of Texas System; University of Texas Austin
摘要：Bacterial evolution, particularly in hospital settings, is leading to an increase in multidrug resistance. Understanding the basis for this resistance is critical as it can drive discovery of new antibiotics while allowing the clinical use of known antibiotics to be optimized. Here, we report a photoactive chemical probe for superresolution microscopy that allows for the in situ probing of antibiotic- induced structural disruption of bacteria. Conjugation between a spiropyran (SP) and galactos...
