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作者:Burunat, Iballa; Levitin, Daniel J.; Toiviainen, Petri
作者单位:University of Jyvaskyla; McGill University
摘要:The perception of musical phrase boundaries is a critical aspect of human musical experience: It allows us to organize, understand, derive pleasure from, and remember music. Identifying boundaries is a prerequisite for segmenting music into meaningful chunks, facilitating efficient processing and storage while providing an enjoyable, fulfilling listening experience through the anticipation of upcoming musical events. Expanding on Sridharan et al.'s [Neuron 55, 521-532 (2007)] work on coarse mu...
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作者:Milton, Ashley M.; Marin-Gual, Laia; Lister, Nicholas C.; McIntyre, Kim L.; Grady, Patrick G. S.; Laird, Melanie K.; Bond, Donna M.; Hore, Timothy A.; O'Neill, Rachel J.; Pask, Andrew J.; Renfree, Marilyn B.; Ruiz-Herrera, Aurora; Waters, Paul D.
作者单位:University of New South Wales Sydney; Autonomous University of Barcelona; Autonomous University of Barcelona; University of Connecticut; University of Connecticut; University of Otago; University of Melbourne
摘要:X chromosome inactivation (XCI) is an epigenetic process that results in the transcriptional silencing of one X chromosome in the somatic cells of females. This phenomenon is common to both eutherian and marsupial mammals, but there are fundamental differences. In eutherians, the X chosen for silencing is random. DNA methylation on the eutherian inactive X is high at transcription start sites (TSSs) and their flanking regions, resulting in universally high DNA methylation. This contrasts XCI i...
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作者:Xun, Hongwei; Wang, Yadi; Yuan, Jing; Lian, Lijie; Feng, Wanjie; Liu, Shuhan; Hong, Jianhui; Liu, Bao; Ma, Jianxin; Wang, Xutong
作者单位:Northeast Normal University - China; Huazhong Agricultural University; Huazhong Agricultural University; Purdue University System; Purdue University; Purdue University System; Purdue University
摘要:Non- CG DNA methylation, a plant- specific epigenetic mark mainly regulated by chromomethylase (CMT), is known to play important roles in Arabidopsis thaliana. However, whether and to what extent non- CG DNA methylation modulates agronomic traits in crops remain to be explored. Here, we describe the consequences of non- CG DNA hypomethylation on development, seed composition, and yield in soybean ( Glycine max ). We created a Gmcmt mutant line lacking function of all four CMT genes. This line ...
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作者:Eatson, Jack L.; Morgan, Scott O.; Horozov, Tommy S.; Buzza, Martin A.
作者单位:University of Hull; University of Hull
摘要:In recent years, self- assembly has emerged as a powerful tool for fabricating functional materials. Since self- assembly is fundamentally determined by the particle interactions in the system, if we can gain full control over these interactions, it would open the door for creating functional materials by design. In this paper, we exploit capillary interactions between colloidal particles at liquid interfaces to create two- dimensional (2D) materials where particle interactions and self- assem...
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作者:Hasan, Prottoy; Berezhnaya, Elena; Rodriguez-Prados, Macarena; Weaver, David; Bekeova, Carmen; Cartes-Saavedra, Benjamin; Birch, Erin; Beyer, Andreas M.; Santos, Janine H.; Seifert, Erin L.; Elrod, John W.; Hajnoczky, Gyorgy
作者单位:Thomas Jefferson University; Medical College of Wisconsin; National Institutes of Health (NIH) - USA; NIH National Institute of Environmental Health Sciences (NIEHS); Pennsylvania Commonwealth System of Higher Education (PCSHE); Temple University
摘要:Activating Ca2+- sensitive enzymes of oxidative metabolism while preventing calcium overload that leads to mitochondrial and cellular injury requires dynamic control of mitochondrial Ca2+ uptake. This is ensured by the mitochondrial calcium uptake (MICU)1/2 proteins that gate the pore of the mitochondrial calcium uniporter (mtCU). MICU1 is relatively sparse in the heart, and recent studies claimed the mammalian heart lacks MICU1 gating of mtCU. However, genetic models have not been tested. We ...
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作者:Shen, Weiyu; Yao, Jie; Yang, Yue
作者单位:Peking University; Beijing Institute of Technology; Peking University
摘要:Matter entanglement is a common chaotic structure found in both quantum and classical systems. For classical turbulence, viscous vortices are like sinews in fluid flows, storing and dissipating energy and accommodating strain and stress throughout a complex vortex network. However, to explain how the statistical properties of turbulence arise from elemental vortical structures remains challenging. Here, we use the quantum vortex tangle as a skeleton to generate an instantaneous classical turbu...
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作者:Battaglioni, Stefania; Craigie, Louise - Marie; Filippini, Sofia; Maier, Timm; Hall, Michael N.
作者单位:University of Basel
摘要:TORC1 (target of rapamycin complex 1) is a highly conserved protein kinase that plays a central role in regulating cell growth. Given the role of mammalian TORC1 (mTORC1) in metabolism and disease, understanding mTORC1 downstream signaling and feedback loops is important. mTORC1 recognizes some of its substrates via a five amino acid binding sequence called the TOR signaling (TOS) motif. mTORC1 binding to a TOS motif facilitates phosphorylation of a distinct, distal site. Here, we show that LS...
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作者:De Deurwaerder, Hannes P. T.; Detto, Matteo; Visser, Marco D.; Schnitzer, Stefan; Pacala, Stephen W.
作者单位:Princeton University; Smithsonian Institution; Smithsonian Tropical Research Institute; Leiden University - Excl LUMC; Leiden University; Marquette University
摘要:Extending and safeguarding tropical forest ecosystems is critical for combating climate change and biodiversity loss. One of its constituents, lianas, is spreading and increasing in abundance on a global scale. This is particularly concerning as lianas negatively impact forests' carbon fluxes, dynamics, and overall resilience, potentially exacerbating both crises. While possibly linked to climate- change- induced atmospheric CO2 elevation and drought intensification, the reasons behind their i...
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作者:Schmickl, Thomas; Karsai, Istvan
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作者:Stromland, Eirik; Koppel, Lina; Johannesson, Magnus; Tinghog, Gustav
作者单位:Western Norway University of Applied Sciences; Linkoping University; Stockholm School of Economics