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作者：Gilormini, Pierre-Andre; Thota, V. Narasimharao; Fers-Lidou, Anthony; Ashmus, Roger A.; Nodwell, Matthew; Brockerman, Jacob; Kuo, Chu-Wei; Wang, Yang; Gray, Taylor E.; Nitin; McDonagh, Anthony W.; Guu, Shih-Yun; Ertunc, Nursah; Yeo, Dominick; Zandberg, Wesley F.; Khoo, Kay-Hooi; Britton, Robert; Vocadlo, David J.
作者单位：Simon Fraser University; Academia Sinica - Taiwan; University of British Columbia; Simon Fraser University
摘要：The fucosylation of glycoproteins regulates diverse physiological processes. Inhibitors that can control cellular levels of protein fucosylation have consequently emerged as being of high interest. One area where inhibitors of fucosylation have gained significant attention is in the production of afucosylated antibodies, which exhibit superior antibody- dependent cell cytotoxicity as compared to their fucosylated counterparts. Here, we describe P-carbafucose, a fucose derivative in which the e...
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作者：Harrison, William J.; Stead, Imogen; Wallis, Thomas S. A.; Bex, Peter J.; Mattingley, Jason B.
作者单位：University of the Sunshine Coast; University of Queensland; University of Queensland; Technical University of Darmstadt; Technical University of Darmstadt; Philipps University Marburg; Northeastern University; Canadian Institute for Advanced Research (CIFAR)
摘要：Coordination of goal - directed behavior depends on the brain's ability to recover the locations of relevant objects in the world. In humans, the visual system encodes the spatial organization of sensory inputs, but neurons in early visual areas map objects according to their retinal positions, rather than where they are in the world. How the brain computes world - referenced spatial information across eye movements has been widely researched and debated. Here, we tested whether shifts of cove...
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作者：Di Cesare, Giuseppe; Lombardi, Giada; Zeidman, Peter; Urgen, Burcu A.; Sciutti, Alessandra; Friston, Karl J.; Rizzolatti, Giacomo
作者单位：University of Parma; Istituto Italiano di Tecnologia - IIT; University of Genoa; University of London; University College London; Ihsan Dogramaci Bilkent University; Ihsan Dogramaci Bilkent University; Ihsan Dogramaci Bilkent University; Ministry of Energy & Natural Resources - Turkey; Ihsan Dogramaci Bilkent University; Consiglio Nazionale delle Ricerche (CNR)
摘要：Goal- directed actions are characterized by two main features: the content (i.e., the action goal) and the form, called vitality forms (VF) (i.e., how actions are executed). It is well another's action are mediated by a network formed by a set of parietal and frontal brain areas. In contrast, the neural bases of action forms (e.g., gentle or rude actions) have not been characterized. However, there are now studies showing that the observation and execution of actions endowed with VF activate, ...
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作者：Koper, Kaan; Han, Sang-Woo; Kothadia, Ramani; Salamon, Hugh; Yoshikuni, Yasuo; Maeda, Hiroshi A.
作者单位：University of Wisconsin System; University of Wisconsin Madison; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Konkuk University; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Joint Genome Institute - JGI; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory; Hokkaido University; Tokyo University of Agriculture & Technology
摘要：Aminotransferases (ATs) are an ancient enzyme family that play central roles in core nitrogen metabolism, essential to all organisms. However, many of the AT enzyme functions remain poorly defined, limiting our fundamental understanding of the nitrogen metabolic networks that exist in different organisms. Here, we traced the deep evolutionary history of the AT family by analyzing AT enzymes from 90 species spanning the tree of life (ToL). We found that each organism has maintained a relatively...
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作者：Beaty, Fiona; Sanchez, P. Santiago Dominguez; Nalven, Katharine Bear; Abrantes, Juliano Palacios; Oken, Kiva L.; Ban, Natalie C.; Nickols, Kerry J.; Juanes, Francis; Okey, Thomas A.; Spalding, Ana K.; Morzaria-Luna, Hem Nalini; Jenkins, Lekelia Danielle; Tulloch, Vivitskaia; Mckechnie, Iain
作者单位：University of British Columbia; University of British Columbia; University of British Columbia; Oregon State University; Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; University of Victoria; California State University System; California State University Northridge; University of Victoria; Smithsonian Institution; Smithsonian Tropical Research Institute; Oregon State University; National Oceanic Atmospheric Admin (NOAA) - USA; Arizona State University; Arizona State University-Downtown Phoenix; University of British Columbia; University of Victoria
摘要：Research has the potential to simultaneously generate new knowledge and contribute meaningful social-ecological benefits; however, research processes and outcomes can also perpetuate extractive patterns that have manifested the climate, biodiversity, and social justice crises. One approach to enhance the societal value of research processes is to strengthen relationships with places of study and the peoples of those places. Deepening relational engagement with the social-ecological context and...
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作者：Tan, Chieh- Hsiang; Wang, Ting - Yu; Park, Heenam; Lomenick, Brett; Chou, Tsui - Fen; Sternberg, Paul W.
作者单位：California Institute of Technology; California Institute of Technology
摘要：The nematode intestine is the primary site for nutrient uptake and storage as well as the synthesis of biomolecules; lysosomerelated organelles known as gut granules are important for many of these functions. Aspects of intestine biology are not well understood, including the export of the nutrients it imports and the molecules it synthesizes, as well as the complete functions and protein content of the gut granules. Here, we report a mass spectrometry (MS)-based proteomic analysis of the inte...
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作者：Wang, Yuan; Qu, Jin; Xiong, Chuxiao; Chen, Bing; Xie, Kai; Wang, Mingxue; Liu, Zhen; Yue, Zhao; Liang, Zhenghua; Wang, Feng; Zhang, Tianlong; Zhu, Guangyu; Kuang, Yi Becki; Shi, Peng
作者单位：City University of Hong Kong; City University of Hong Kong; City University of Hong Kong; Hong Kong University of Science & Technology; Hong Kong University of Science & Technology; City University of Hong Kong; City University of Hong Kong; Shenzhen Research Institute, City University of Hong Kong
摘要：Despite the tremendous clinical potential of nucleic acid-based vaccines, their efficacy to induce therapeutic immune response has been limited by the lack of efficient local gene delivery techniques in the human body. In this study, we develop a hydrogel - based organic electronic device ( mu EPO) for both transdermal delivery of nucleic acids and in vivo microarrayed cell electroporation, which is specifically oriented toward one - step transfection of DNAs in subcutaneous antigen - presenti...
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作者：Hua, Wei; Zhang, Wenpeng; Brown, Hannah; Wu, Junhan; Fang, Xinqi; Shah, Mahdiyeh; Chen, Rong; Zhang, Haoyue; Jiao, Bin; Wang, Nan; Xu, Hao; Fu, Minjie; Wang, Xiaowen; Zhang, Jinsen; Zhang, Xin; Wang, Qijun; Zhu, Wei; Ye, Dan; Garcia, Diogo Moniz; Chaichana, Kaisorn; Cooks, R. Graham; Ouyang, Zheng; Mao, Ying; Hinojosa, Alfredo Quinones -
作者单位：Fudan University; Fudan University; Tsinghua University; Purdue University System; Purdue University; Fudan University; Mayo Clinic
摘要：The development and performance of two mass spectrometry (MS) workflows for the intraoperative diagnosis of isocitrate dehydrogenase (IDH) mutations in glioma is implemented by independent teams at Mayo Clinic, Jacksonville, and Huashan Hospital, Shanghai. The infiltrative nature of gliomas makes rapid diagnosis necessary to guide the extent of surgical resection of central nervous system (CNS) tumors. The combination of tissue biopsy and MS analysis used here satisfies this requirement. The k...
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作者：Wang, Siyu; Zhang, Yuebao; Zhong, Yichen; Xue, Yonger; Liu, Zhengwei; Wang, Chang; Kang, Diana D.; Li, Haoyuan; Hou, Xucheng; Tian, Meng; Cao, Dinglingge; Wang, Leiming; Guo, Kaiyuan; Deng, Binbin; Mccomb, David W.; Merad, Miriam; Brown, Brian D.; Abcdefg, Yizhou Dong; Murphy, Catherine
作者单位：Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; University System of Ohio; Ohio State University; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai
摘要：Current treatment options for diabetic wounds face challenges due to low efficacy, as well as potential side effects and the necessity for repetitive treatments. To address these issues, we report a formulation utilizing trisulfide - derived lipid nanoparticle (TS LNP) - mRNA therapy to accelerate diabetic wound healing by repairing and reprogramming the microenvironment of the wounds. A library of reactive oxygen species (ROS) - responsive TS LNPs was designed and developed to encapsulate int...
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作者：Goyette, Marie-Anne; Stevens, Laura E.; Depinho, Carolyn R.; Seehawer, Marco; Nishida, Jun; Li, Zheqi; Wilde, Callahan M.; Li, Rong; Qiu, Xintao; Pyke, Alanna L.; Zhao, Stephanie; Lim, Klothilda; Tender, Gabrielle S.; Northey, Jason J.; Riley, Nicholas M.; Long, Henry W.; Bertozzi, Carolyn R.; Weaver, Valerie M.; Polyak, Kornelia
作者单位：Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Brigham & Women's Hospital; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Stanford University; University of California System; University of California San Francisco; Howard Hughes Medical Institute; Stanford University; Stanford University; University of California System; University of California San Francisco; UCSF Medical Center; UCSF Helen Diller Family Comprehensive Cancer Center; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco; University of California System; University of California San Francisco
摘要：Brain metastatic breast cancer is particularly lethal largely due to therapeutic resistance. Almost half of the patients with metastatic HER2positive breast cancer develop brain metastases, representing a major clinical challenge. We previously described that cancer - associated fibroblasts are an important source of resistance in primary tumors. Here, we report that breast cancer brain metastasis stromal cell interactions in 3D cocultures induce therapeutic resistance to HER2targeting agents,...
