Impact of repeated blast exposure on active- duty United States Special Operations Forces

• 成果类型: Article
• 署名作者: Gilmore, Natalie; Tseng, Chieh- En J.; Maffei, Chiara; Tromly, Samantha L.; Deary, Katryna B.; Mckinney, Isabella R.; Kelemen, Jessica N.; Healy, Brian C.; Hu, Collin G.; Llorden, Gabriel Ramos -; Masood, Maryam; Cali, Ryan J.; Guo, Jennifer; Belanger, Heather G.; Yao, Eveline F.; Baxter, Timothy; Fischl, Bruce; Foulkes, Andrea S.; Polimeni, Jonathan R.; Rosen, Bruce R.; Perl, Daniel P.; Hooker, Jacob M.; Zuercher, Nicole R.; Huang, Susie Y.; Kimberly, W. Taylor; Greve, Douglas N.; Donald, Christine L. Mac; O'Connor, Kristen Dams -; Bodien, Yelena G.; Abc, Brian L. Edlow
• 署名单位: Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; State University System of Florida; University of South Florida; Harvard University; Harvard T.H. Chan School of Public Health; Uniformed Services University of the Health Sciences - USA; State University System of Florida; University of South Florida; Uniformed Services University of the Health Sciences - USA; University of Washington; University of Washington Seattle; Icahn School of Medicine at Mount Sinai; Icahn School of Medicine at Mount Sinai; Harvard University; Harvard Medical School; Harvard University Medical Affiliates; Spaulding Rehabilitation Hospital
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10471
• DOI: 10.1073/pnas.2313568121
• 发表日期: 2024-05-07
• 关键词: traumatic brain-injury; volumetric navigators; prospective motion; MODEL

摘要

United States (US) Special Operations Forces (SOF) are frequently exposed to explosive brain health are incompletely understood. Furthermore, there is no diagnostic test to detect brain injury from RBE. As a result, SOF personnel may experience cognitive, physical, and psychological symptoms for which the cause is never identified, and they may return to training or combat during a period of brain vulnerability. In 30 active- duty US SOF, we assessed the relationship between cumulative blast exposure and cognitive performance, psychological health, physical symptoms, blood proteomics, and neuroimaging measures (Connectome structural and diffusion MRI, 7 Tesla functional MRI, trauma. Higher blast exposure was associated with increased cortical thickness in the left rostral anterior cingulate cortex (rACC), a finding that remained significant after multiple comparison correction. In uncorrected analyses, higher blast exposure was associated with worse health- related quality of life, decreased functional connectivity in the executive control network, decreased TSPO signal in the right rACC, and increased cortical thickness in the right rACC, right insula, and right medial orbitofrontal cortex- nodes of the executive control, salience, and default mode networks. These observations suggest that the rACC may be susceptible to blast overpressure and that a multimodal, network- based diagnostic approach has the potential to detect brain injury associated with RBE in active- duty SOF.