2024

最新文章

• H2S preconditioning induces long- lived perturbations in O2 metabolism AI翻译
  作者：Hanna, David A.; Diessl, Jutta; Guha, Arkajit; Kumar, Roshan; Andren, Anthony; Lyssiotis, Costas; Banerjee, Ruma
  作者单位：University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan; University of Michigan System; University of Michigan
  摘要：Hydrogen sulfide exposure in moderate doses can induce profound but reversible hypometabolism in mammals. At a cellular level, H2S inhibits the electron transport chain (ETC), augments aerobic glycolysis, and glutamine- dependent carbon utilization via reductive carboxylation; however, the durability of these changes is unknown. We report that despite its volatility, H2S preconditioning increases P50(O2), the O2 pressure for half- maximal cellular respiration, and has pleiotropic effects on ox...
• Balance and imbalance in biogeochemical cycles reflect the operation of closed, exchange, and open sets AI翻译
  作者：Kemeny, Preston Cosslett; Torres, Mark A.; Fischer, Woodward W.; Blattler, Clara L.
  作者单位：University of Chicago; Rice University; California Institute of Technology
  摘要：Biogeochemical reactions modulate the chemical composition of the oceans and atmosphere, providing feedbacks that sustain planetary habitability over geological time. Here, we mathematically evaluate a suite of biogeochemical processes to identify combinations of reactions that stabilize atmospheric carbon dioxide by balancing fluxes of chemical species among the ocean, atmosphere, and geosphere. Unlike prior modeling efforts, this approach does not prescribe functional relationships between t...
• Heterogeneous elasticity drives ripening and controls bursting kinetics of transcriptional condensates AI翻译
  作者：Meng, Lingyu; Mao, Sheng; Lin, Jie
  作者单位：Peking University; Peking University; Peking University
  摘要：Many biomolecular condensates, including transcriptional condensates, are formed in elastic mediums. In this work, we study the nonequilibrium condensate dynamics in a chromatin -like environment modeled as a heterogeneous elastic medium. We demonstrate that the ripening process in such an elastic medium exhibits a temporal power -law scaling of the average condensate radius, depending on the local stiffness distribution and different from Ostwald ripening. Moreover, we incorporate an active p...
• Heritability within groups is uninformative about differences among groups: Cases from behavioral, evolutionary, and statistical genetics AI翻译
  作者：Schraiber, Joshua G.; Edge, Michael D.
  作者单位：University of Southern California
  摘要：Without the ability to control or randomize environments (or genotypes), it is difficult to determine the degree to which observed phenotypic differences between two groups of individuals are due to genetic vs. environmental differences. However, some have suggested that these concerns may be limited to pathological cases, and methods have appeared that seem to give-directly or indirectly-some support to claims that aggregate heritable variation within groups can be related to heritable variat...
• A magnetic separation method for isolating and characterizing the biomolecular corona of lipid nanoparticles AI翻译
  作者：Francia, Valentina; Zhang, Yao; Cheng, Miffy Hok Yan; Schiffelers, Raymond M.; Witzigmann, Dominik; Cullis, Pieter R.
  作者单位：University of British Columbia; Utrecht University; Utrecht University Medical Center
  摘要：Lipid nanoparticle (LNP) formulations are a proven method for the delivery of nucleic acids for gene therapy as exemplified by the worldwide rollout of LNP-based RNAi therapeutics and mRNA vaccines. However, targeting specific tissues or cells is still a major challenge. After LNP administration, LNPs interact with biological fluids (i.e., blood), components of which adsorb onto the LNP surface forming a layer of biomolecules termed the biomolecular corona (BMC) which affects LNP stability, bi...
• 撤稿声明: Neurexin-2 restricts synapse numbers and restrains the presynaptic release probability by an alternative splicing-dependent mechanism (Retraction of Vol 120, art no E2300363120, 2023) AI翻译
  作者：Lin, Pei- Yi; Chen, Lulu Y.; Zhou, Peng; Lee, Sung-Jin; Trotter, Justin H.; Sudhof, Thomas C.
  作者单位：Stanford University; University of California System; University of California Irvine; Stanford University; Howard Hughes Medical Institute
• Environmental radiation exposure at Chornobyl has not systematically affected the genomes or chemical mutagen tolerance phenotypes of local worms AI翻译
  作者：Tintori, Sophia C.; Caglar, Derin; Ortiz, Patrick; Chyzhevskyi, Ihor; Mousseau, Timothy A.; Rockman, Matthew, V
  作者单位：New York University; New York University; University of South Carolina System; University of South Carolina Columbia
  摘要：The 1986 disaster at the Chornobyl Nuclear Power Plant transformed the surrounding region into the most radioactive landscape known on the planet. Whether or not this sudden environmental shift selected for species, or even individuals within a species, that are naturally more resistant to mutagen exposure remains an open question. In this study, we collected, cultured, and cryopreserved 298 wild nematode isolates from areas varying in radioactivity within the Chornobyl Exclusion Zone. We sequ...
• Anthropogenic short- lived halogens increase human exposure to mercury contamination due to enhanced mercury oxidation over continents AI翻译
  作者：Fu, Xiao; Sun, Xianyi; Travnikov, Oleg; Li, Qinyi; Qin, Chuang; Cuevas, Carlos A.; Fernandez, Rafael P.; Mahajan, Anoop S.; Wang, Shuxiao; Wang, Tao; Saiz-Lopez, Alfonso
  作者单位：Tsinghua University; Tsinghua Shenzhen International Graduate School; Slovenian Academy of Sciences & Arts (SASA); Jozef Stefan Institute; Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto de Quimica Fisica Blas Cabrera (IQF-CSIC); Hong Kong Polytechnic University; Shandong University; University Nacional Cuyo Mendoza; Ministry of Earth Sciences (MoES) - India; Indian Institute of Tropical Meteorology (IITM); Centre for Climate Change Research - India; Tsinghua University
  摘要：Mercury (Hg) is a contaminant of global concern, and an accurate understanding of its atmospheric fate is needed to assess its risks to humans and ecosystem health. Atmospheric oxidation of Hg is key to the deposition of this toxic metal to the Earth's surface. Short - lived halogens (SLHs) can provide halogen radicals to directly oxidize Hg and perturb the budget of other Hg oxidants (e.g., OH and O3). In addition to known ocean emissions of halogens, recent observational evidence has reveale...
• Three- atom- wide gold quantum rods with periodic elongation and strongly polarized excitons AI翻译
  作者：Luo, Lianshun; Liu, Zhongyu; Kong, Jie; Gianopoulos, Christopher G.; Coburn, Isabelle; Kirschbaum, Kristin; Zhou, Meng; Jin, Rongchao
  作者单位：Carnegie Mellon University; Chinese Academy of Sciences; University of Science & Technology of China, CAS; University System of Ohio; University of Toledo
  摘要：Atomically precise control over anisotropic nanoclusters constitutes a grand challenge in nanoscience. In this work, we report our success in achieving a periodic series of atomically precise gold quantum rods (abbrev. Au QRs) with unusual excitonic properties. These QRs possess hexagonal close- packed kernels with a constant three- atom diameter but increasing aspect ratios (ARs) from 6.3 to 18.7, all being protected by the same thiolate (SR) ligand. The kernels of the QRs are in a Au1-(Au3)n...
• Unraveling the impact of a glyco- immune checkpoint in bone metastasis AI翻译
  作者：Laubli, Heinz
  作者单位：University of Basel; University of Basel