-
作者：Stringer, Emily J.; Gruber, Bernd; Sarre, Stephen D.; Wardle, Glenda M.; Edwards, Scott V.; Dickman, Christopher R.; Greenville, Aaron C.; Duncan, Richard P.
作者单位：University of Canberra; University of Sydney; Harvard University
摘要：Increasing environmental threats and more extreme environmental perturbations place species at risk of population declines, with associated loss of genetic diversity and evolutionary potential. While theory shows that rapid population declines can cause loss of genetic diversity, populations in some environments, like Australia's arid zone, are repeatedly subject to major population fluctuations yet persist and appear able to maintain genetic diversity. Here, we use repeated population samplin...
-
作者：Bakiri, Latifa; Hasenfuss, Sebastian C.; Guio-Carrion, Ana; Thomsen, Martin K.; Hasselblatt, Peter; Wagner, Erwin F.
作者单位：Medical University of Vienna; Aarhus University; Medical University of Vienna; Beam Therapeutics, Inc.; Centro Nacional de Investigaciones Cardiovasculares (CNIC)
摘要：Hepatocellular carcinoma (HCC) is a leading cause of cancer - related death. HCC incidence is on the rise, while treatment options remain limited. Thus, a better understanding of the molecular pathways involved in HCC development has become a priority to guide future therapies. While previous studies implicated the Activator Protein - 1 (AP - 1) (Fos/Jun) transcription factor family members c - Fos and c - Jun in HCC formation, the contribution of Fos - related antigens (Fra - ) 1 and 2 is unk...
-
作者：Adam, David
-
作者：Schmutz, Anja; Schoeb, Christian
作者单位：Swiss Federal Institutes of Technology Domain; ETH Zurich; Universidad Rey Juan Carlos
摘要：Growing crops in more diverse crop systems (i.e., intercropping) is one way to produce food more sustainably. Even though intercropping, compared to average monocultures, is generally more productive, the full yield potential of intercropping might not yet have been achieved as modern crop cultivars are bred to be grown in monoculture. Breeding plants for more familiarity in mixtures, i.e., plants that are adapted to more diverse communities (i.e., adaptation) or even to coexist with each othe...
-
作者：Li, Haiou; Sun, Yishuang; Yao, Yingmeng; Ke, Shanwen; Zhang, Nannan; Xiong, Wenjun; Shi, Jie; He, Chuan; Xiao, Xiangling; Yu, Haisheng; Dai, Panpan; Xiang, Bolin; Xing, Xixin; Xu, Gaoshan; Song, Wenjing; Song, Jiquan; Zhang, Jinfang
作者单位：Wuhan University; Wuhan University; Zhengzhou University; Zhengzhou University; Wuhan University; Wuhan University
摘要：Ferroptosis is an iron- dependent type of regulated cell death resulting from extensive lipid peroxidation and plays a critical role in various physiological and pathological processes. However, the regulatory mechanisms for ferroptosis sensitivity remain incompletely understood. Here, we report that homozygous deletion of Usp8 (ubiquitin- specific protease 8) in intestinal epithelial cells (IECs) leads to architectural changes in the colonic epithelium and shortens mouse lifespan accompanied ...
-
作者：Albano, Paolo G.; Schultz, Lotta; Wessely, Johannes; Taviani, Marco; Dullinger, Stefan; Danise, Silvia
作者单位：Stazione Zoologica Anton Dohrn; University of Bergen; University of Vienna; Consiglio Nazionale delle Ricerche (CNR); Istituto di Scienze Marine (ISMAR-CNR); Stazione Zoologica Anton Dohrn; University of Florence
摘要：The Mediterranean Sea is a marine biodiversity hotspot already affected by climate- driven biodiversity collapses. Its highly endemic fauna is at further risk if global warming triggers an invasion of tropical Atlantic species. Here, we combine modern species occurrences with a unique paleorecord from the Last Interglacial (135 to 116 ka), a conservative analog of future climate, to model the future distribution of an exemplary subset of tropical West African mollusks, currently separated from...
-
作者：Baharav, Tavor Z.; Tse, David; Salzman, Julia
作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard University Medical Affiliates; Dana-Farber Cancer Institute; Stanford University; Stanford University; Stanford University; Stanford University
摘要：Contingency tables, data represented as counts matrices, are ubiquitous across quantitative research and data-science applications. Existing statistical tests are insufficient however, as none are simultaneously computationally efficient and statistically valid for a finite number of observations. In this work, motivated by a recent application in reference-free genomic inference [K. Chaung et al., Cell 186, 5440-5456 (2023)], we develop Optimized Adaptive Statistic for Inferring Structure (OA...
-
作者：Paul, Indrajit; Konieczny, Krzysztof A.; Chavez, Roberto; Garcia-Garibay, Miguel A.
作者单位：University of California System; University of California Los Angeles
摘要：Photochemical valence bond isomerization of a crystalline Dewar benzene (DB) diacid monoanion salt with an acetophenone-linked piperazinium cation that serves as an intramolecular triplet energy sensitizer (DB- AcPh-Pz) exhibits a quantum chain reaction with as many as 450 product molecules per photon absorbed (Phi = 450). By contrast, isomorphous crystals of the DB diacid monosalt of an ethylbenzene- linked piperazinium (DB- EtPh-Pz) lacking a triplet sensitizer showed a less impressive quant...
-
作者：Challita, Elio J.; Bhamla, M. Saad
作者单位：University System of Georgia; Georgia Institute of Technology
摘要：Can insects weighing mere grams challenge our current understanding of fluid dynamics in urination, jetting fluids like their larger mammalian counterparts? Current fluid urination models, predominantly formulated for mammals, suggest that jetting is confined to animals over 3 kg, owing to viscous and surface tension constraints at microscales. Our findings defy this paradigm by demonstrating that cicadas-weighing just 2 g-possess the capability for jetting fluids through remarkably small orif...
-
作者：Ma, Yang; Yan, Guanxiong; Zhang, Jing; Xiong, Jie; Miao, Wei
作者单位：Chinese Academy of Sciences; Institute of Hydrobiology, CAS; Chinese Academy of Sciences; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Hubei Hongshan Laboratory; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
摘要：Mating type (sex) plays a crucial role in regulating sexual reproduction in most extant eukaryotes. One of the functions of mating types is ensuring self- incompatibility to some extent, thereby promoting genetic diversity. However, heterothallic mating is not always the best mating strategy. For example, in low- density populations or specific environments, such as parasitic ones, species may need to increase the ratio of potential mating partners. Consequently, many species allow homothallic...
