2024

最新文章

• Observing many researchers using the same data and hypothesis reveals a hidden universe of uncertainty (vol 119, e2203150119, 2022) AI翻译
  作者：Breznau, Nate; Rinke, Eike Mark; Wuttke, Alexander; Nguyen, Hung H. V.; Adem, Muna; Adriaans, Jule; Alvarez-Benjumea, Amalia; Andersen, Henrik K.; Auer, Daniel; Azevedo, Flavio; Bahnsen, Oke; Balzer, Dave; Bauer, Gerrit; Bauer, Paul C.; Baumann, Markus; Baute, Sharon; Benoit, Verena; Bernauer, Julian; Berning, Carl; Berthold, Anna; Bethke, Felix S.; Biegert, Thomas; Blinzler, Katharina; Blumenberg, Johannes N.; Bobzien, Licia; Bohman, Andrea; Bol, Thijs; Brzozowska, Amie Bostic Zuzanna; Burgdorf, Katharina; Burger, Kaspar; Busch, Kathrin B.; Castillo, Juan Carlos-; Christmann, Pablo; Connelly, Roxanne; Czymara, Christian S.; Damian, Elena; Ecker, Alejandro; Edelmann, Achim; Eger, Maureen A.; Ellerbrock, Simon; Forke, Anna; Forster, Andrea; Gaasendam, Chris; Gavras, Konstantin; Gayle, Vernon; Gessler, Theresa; Gnambs, Timo; Godefroidt, Amelie; Gromping, Max; Gross, Martin; Gruber, Stefan; Gummer, Tobias; Hadjar, Andreas; Heisig, Jan Paul; Hellmeier, Sebastian; Heyne, Stefanie; Hirsch, Magdalena; Hjerm, Mikael; Hochman, Oshrat; Hoevermann, Andreas; Hunger, Sophia; Hunkler, Christian; Huth, Nora; Ignacz, Zsofia S.; Jacobs, Laura; Jacobsen, Jannes; Jaeger, Bastian; Jungkunz, Sebastian; Jungmann, Nils; Kauff, Mathias; Kleinert, Manuel; Klinger, Julia; Kolb, Jan- Philipp; Kolczynska, Marta; Kuk, John; Kunissen, Katharina; Sinatra, Dafina Kurti; Langenkamp, Alexander; Lersch, Philipp M.; Lobel, Lea- Maria; Lutscher, Philipp; Mader, Matthias; Madia, Joan E.; Malancu, Natalia; Maldonado, Luis; Marahrens, Helge; Martin, Nicole; Martinez, Paul; Mayerl, Jochen; Mayorga, Oscar J.; McManus, Patricia; McWagner, Kyle; Meeusen, Cecil; Meierrieks, Daniel; Mellon, Jonathan; Merhout, Friedolin; Merk, Samuel; Meyer, Daniel; Micheli, Leticia; Mijs, Jonathan; Moya, Cristobal; Neunhoeffer, Marcel; Nust, Daniel; Nygard, Olav; Ochsenfeld, Fabian; Otte, Gunnar; Pechenkina, Anna O.; Prosser, Christopher; Raes, Louis; Ralston, Kevin; Ramos, Miguel R.; Roets, Arne; Rogers, Jonathan; Ropers, Guido; Samuel, Robin; Sand, Gregor; Schachter, Ariela; Schaeffer, Merlin; Schieferdecker, David; Schlueter, Elmar; Schmidt, Regine; Schmidt, M.; Schmidt-Catran, Alexander; Schmiedeberg, Claudia; Schneider, Jurgen; Schoonvelde, Martijn; Schulte-Cloos, Julia; Schumann, Sandy; Schunck, Reinhard; Schupp, Jurgen; Seuring, Julian; Silber, Henning; Sleegers, Willem; Sonntag, Nico; Staudt, Alexander; Steiber, Nadia; Steiner, Nils; Sternberg, Sebastian; Stiers, Dieter; Stojmenovska, Dragana; Storz, Nora; Striessnig, Erich; Stroppe, Anne- Kathrin; Teltemann, Janna; Tibajev, Andrey; Tung, Brian; Vagni, Giacomo; Van Assche, Jasper; van der Linden, Meta; van der Noll, Jolanda; Van Hootegem, Arno; Vogtenhuber, Stefan; Voicu, Bogdan; Wagemans, Fieke; Wehl, Nadja; Werner, Hannah; Wiernik, Brenton M.; Winter, Fabian; Wolf, Christof; Yamada, Yuki; Zhang, Nan; Ziller, Conrad; Zins, Stefan; Zoltak, Tomasz
• It pays to follow the leader: Metabolic cost of flight is lower for trailing birds in small groups AI翻译
  作者：Friman, Sonja I.; Elowe, Cory R.; Hao, Siyang; Mendez, Laura; Ayala, Raul; Brown, Ian; Hagood, Caylan; Hedlund, Yseult; Jackson, Dayna; Killi, Justin; Orfanides, Gabriella; Ozcan, Evrim; Ramirez, Jared; Gerson, Alexander R.; Breuer, Kenneth S.; Hedrick, Tyson L.; Edwards, V.
  作者单位：University of North Carolina; University of North Carolina Chapel Hill; University of Massachusetts System; University of Massachusetts Amherst; Brown University; Howard University; Rochester Institute of Technology; University of Southern California
  摘要：Many bird species commonly aggregate in flocks for reasons ranging from predator defense to navigation. Available evidence suggests that certain types of flocks-the V and echelon formations of large birds-may provide a benefit that reduces the aerodynamic cost of flight, whereas cluster flocks typical of smaller birds may increase flight costs. However, metabolic flight costs have not been directly measured in any of these group flight contexts [Zhang and Lauder, J. Exp. Biol. 226 , jeb245617 ...
• MDGA1 negatively regulates amyloid precursor protein-mediated synapse inhibition in the hippocampus (vol 119, e2115326119, 2022) AI翻译
  作者：Kim, Jinhu; Kim, Seungjoon; Kim, Hyeonho; Hwang, In-Wook; Bae, Sungwon; Karki, Sudeep; Kim, Dongwook; Ogelman, Roberto; Bang, Geul; Kim, Jin Young; Kajander, Tommi; Um, Ji Won; Oh, Won Chan; Ko, Jaewon
• Upstream surface roughness and terrain are strong drivers of contrast in tornado potential between North and South America AI翻译
  作者：Li, Funing; Chavas, Daniel R.; Medeiros, Brian; Reed, Kevin A.; Rasmussen, Kristen L.
  作者单位：Purdue University System; Purdue University; National Center Atmospheric Research (NCAR) - USA; State University of New York (SUNY) System; Stony Brook University; Colorado State University System; Colorado State University Fort Collins
  摘要：Central North America is the global hotspot for tornadoes, fueled by elevated terrain of the Rockies to the west and a source of warm, moist air from equatorward oceans. This conventional wisdom argues that central South America, with the Andes to the west and Amazon basin to the north, should have a tornado alley at least as active as central North America. Central South America has frequent severe thunderstorms yet relatively few tornadoes. Here, we show that conventional wisdom is missing a...
• Self- assembling dendrimer nanosystems for specific fluorine magnetic resonance imaging and effective theranostic treatment of tumors AI翻译
  作者：Lyu, Zhenbin; Ralahy, Brigino; Barbacaru, Teodora- Adriana Perles-; Ding, Ling; Jiang, Yifan; Lian, Baoping; Roussel, Tom; Liu, Xi; Galanakou, Christina; Laurini, Erik; Tintaru, Aura; Giorgio, Suzanne; Pricl, Sabrina; Liu, Xiaoxuan; Bernard, Monique; Iovanna, Juan; Viola, Angele; Peng, Ling
  作者单位：Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Aix-Marseille Universite; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute for Engineering & Systems Sciences (INSIS); China Pharmaceutical University; China Pharmaceutical University; Institut National de la Sante et de la Recherche Medicale (Inserm); Aix-Marseille Universite; UNICANCER; Institut Paoli-Calmette (IPC); Centre National de la Recherche Scientifique (CNRS); CNRS - National Institute for Biology (INSB); University of Trieste; University of Lodz
  摘要：Fluorine magnetic resonance imaging ( 19 F - MRI) is particularly promising for biomedical applications owing to the absence of fluorine in most biological systems. However, its use has been limited by the lack of safe and water - soluble imaging agents with high fluorine contents and suitable relaxation properties. We report innovative 19 F - MRI agents based on supramolecular dendrimers self - assembled by an amphiphilic dendrimer composed of a hydrophobic alkyl chain and a hydrophilic dendr...
• Developmental hearing loss-induced perceptual deficits are rescued by genetic restoration of cortical inhibition AI翻译
  作者：Masri, Samer; Mowery, Todd M.; Fair, Regan; Sanes, Dan H.
  作者单位：New York University; Rutgers University System; Rutgers University New Brunswick; New York University; New York University; New York University; NYU Langone Medical Center
  摘要：Even a transient period of hearing loss during the developmental critical period can induce long - lasting deficits in temporal and spectral perception. These perceptual deficits correlate with speech perception in humans. In gerbils, these hearing loss-induced perceptual deficits are correlated with a reduction of both ionotropic GABA A and metabotropic GABA B receptor-mediated synaptic inhibition in auditory cortex, but most research on critical period plasticity has focused on GABA A recept...
• Emergent facilitation and glassy dynamics in supercooled liquids AI翻译
  作者：Hasyim, Muhammad R.; Mandadapu, Kranthi K.
  作者单位：University of California System; University of California Berkeley; United States Department of Energy (DOE); Lawrence Berkeley National Laboratory
  摘要：In supercooled liquids, dynamical facilitation refers to a phenomenon where microscopic motion begets further motion nearby, resulting in spatially heterogeneous dynamics. This is central to the glassy relaxation dynamics of such liquids, which show super-Arrhenius growth of relaxation timescales with decreasing temperature. Despite the importance of dynamical facilitation, there is no theoretical understanding of how facilitation emerges and impacts relaxation dynamics. Here, we present a the...
• NAD activates olfactory receptor 1386 to regulate type I interferon responses in Plasmodium yoelii YM infection AI翻译
  作者：Peng, Yu- chih; Wu, Jian; He, Xiao; Dai, Jin; Xia, Lu; Valenzuela-Leon, Paola; Tumas, Keyla C.; Singh, Brajesh K.; Xu, Fangzheng; Ganesan, Sundar; Munir, Shirin; Calvo, Eric; Huang, Ruili; Liu, Chengyu; Long, Carole A.; Su, Xin-zhuan
  作者单位：National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); Central South University; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID); National Institutes of Health (NIH) - USA; NIH National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
  摘要：Olfactory receptors (Olfr) are G protein-coupled receptors that are normally expressed on olfactory sensory neurons to detect volatile chemicals or odorants. Interestingly, many Olfrs are also expressed in diverse tissues and function in cell-cell recognition, migration, and proliferation as well as immune responses and disease processes. Here, we showed that many Olfr genes were expressed in the mouse spleen, linked to Plasmodium yoelii genetic loci significantly, and/or had genome - wide pat...
• Solar- enhanced lithium extraction with self- sustaining water recycling from salt- lake brines AI翻译
  作者：Xia, Qiancheng; Deng, Zehui; Sun, Siwei; Zhao, Wei; Ding, Jie; Xi, Beidou; Gao, Guandao; Wang, Chao
  作者单位：Nanjing University; Yangzhou University; Nanjing University; Chinese Research Academy of Environmental Sciences; Nanjing University
  摘要：Lithium is an emerging strategic resource for modern energy transformation toward electrification and decarbonization. However, current mainstream direct lithium extraction technology via adsorption suffers from sluggish kinetics and intensive water usage, especially in arid/semiarid and cold salt-lake regions (natural land brines). Herein, an efficient proof-of-concept integrated solar microevaporator system is developed to realize synergetic solar-enhanced lithium recovery and water footprin...
• EHMT2-mediated transcriptional reprogramming drives neuroendocrine transformation in non-small cell lung cancer AI翻译
  作者：Yang, Cheng; Ma, Shuxiang; Zhang, Jie; Han, Yuchen; Wan, Li; Zhou, Wenlong; Dong, Xiaoyu; Yang, Weiming; Chen, Yu; Gao, Lingyue; Cui, Wei; Jia, Lina; Yang, Jingyu; Wu, Chunfu; Wang, Qiming; Wang, Lihui
  作者单位：Shenyang Pharmaceutical University; Shenyang Pharmaceutical University; Zhengzhou University; Zhengzhou University
  摘要：The transformation of lung adenocarcinoma to small cell lung cancer (SCLC) is a recognized resistance mechanism and a hindrance to therapies using epidermal growth factor receptor tyrosine kinase inhibitors (TKIs). The paucity of pretranslational/posttranslational clinical samples limits the deeper understanding of resistance mechanisms and the exploration of effective therapeutic strategies. Here, we developed preclinical neuroendocrine (NE) transformation models. Next, we identified a transc...