Septo- dentate gyrus cholinergic circuits modulate function and morphogenesis of adult neural stem cells through granule cell intermediaries

• 成果类型: Article
• 署名作者: Chen, Ze- Ka; Quintanilla, Luis; Su, Yijing; Sheehy, Ryan N.; Simon, Jeremy M.; Luo, Yan-Jia; Li, Ya- Dong; Chen, Zhe; Asrican, Brent; Tart, Dalton S.; Farmer, W. Todd; Ming, Guo-Li; Song, Hongjun; Song, Juan
• 署名单位: University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of Pennsylvania; University of Pennsylvania; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine; University of North Carolina; University of North Carolina Chapel Hill; University of North Carolina School of Medicine
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10431
• DOI: 10.1073/pnas.2405117121
• 发表日期: 2024-10-01
• 关键词: diagonal band; rna-seq; acetylcholine; neurogenesis; hippocampus; DYNAMICS; nucleus; neurons; memory

摘要

Cholinergic neurons in the basal forebrain play a crucial role in regulating adult hippocampal neurogenesis (AHN). However, the circuit and molecular mechanisms underlying cholinergic modulation of AHN, especially the initial stages of this process related to the generation of newborn progeny from quiescent radial neural stem cells (rNSCs), remain unclear. Here, we report that stimulation of the cholinergic circuits projected from the diagonal band of Broca (DB) to the dentate gyrus (DG) neurogenic niche promotes proliferation and morphological development of rNSCs, resulting in increased neural stem/progenitor pool and rNSCs with longer radial processes and larger busy dependent modulation of proliferation and morphogenesis of rNSCs. Furthermore, in response to cholinergic circuit stimulation, with GCs (among all the DG niche cells) exhibiting the most extensive transcriptional changes. Our findings shed light on neurogenic function and morphogenesis of rNSCs at the circuit and molecular levels.