2024

最新文章

• Structural insights into the assembly and energy transfer of haptophyte photosystem I-light- harvesting supercomplex AI翻译
  作者：He, Fei-Yu; Zhao, Long-Sheng; Qu, Xin-Xiao; Li, Kang; Guo, Jian-Ping; Zhao, Fang; Wang, Ning; Qin, Bing-Yue; Chen, Xiu-Lan; Gao, Jun; Liu, Lu-Ning; Zhang, Yu-Zhong
  作者单位：Shandong University; Ocean University of China; Ocean University of China; Huazhong Agricultural University; University of Liverpool
  摘要：Haptophyta represents a major taxonomic group, with plastids derived from the primary plastids of red algae. Here, we elucidated the cryoelectron microscopy structure of the photosystem I-light- harvesting complex I (PSI-LHCI) supercomplex from the haptophyte Isochrysis galbana. The PSI core comprises 12 subunits, which have evolved differently from red algae and cryptophytes by losing the PsaO subunit while incorporating the PsaK subunit, which is absent in diatoms and dinoflagellates. The PS...
• Colossal magnetoresistance from spin-polarized polarons in an Ising system AI翻译
  作者：Li, Ying-Fei; Been, Emily M.; Balguri, Sudhaman; Jia, Chun-Jing; Mahendru, Mira B.; Wang, Zhi-Cheng; Cui, Yi; Chen, Su-Di; Hashimoto, Makoto; Lu, Dong-Hui; Moritz, Brian; Zaanen, Jan; Tafti, Fazel; Devereaux, Thomas P.; Shen, Zhi-Xun
  作者单位：Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Stanford University; Stanford University; Boston College; State University System of Florida; University of Florida; University of California System; University of California Berkeley; Stanford University; United States Department of Energy (DOE); SLAC National Accelerator Laboratory; Leiden University - Excl LUMC; Leiden University; Stanford University
  摘要：Recent experiments suggest a new paradigm toward novel colossal magnetoresistance (CMR) in a family of materials EuM2X2 (M = Cd, In, Zn; X = P, As), distinct from the traditional avenues involving Kondo-Ruderman-Kittel-Kasuya-Yosida crossovers, magnetic phase transitions with structural distortions, or topological phase transitions. Here, we use angle-resolved photoemission spectroscopy and density functional theory calculations to explore their origin, particularly focusing on EuCd2P2. While ...
• Photoinduced ultrafast multielectron transfer and long- lived charge- accumulated state in a fullerene- indacenodithiophene dumbbell triad AI翻译
  作者：Wang, Chong; Wu, Bo; Li, Yang; Jiang, Ying; Dong, Tianyang; Zhou, Shen; Wang, Chunru; Bai, Chunli
  作者单位：Chinese Academy of Sciences; Institute of Chemistry, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Beijing University of Posts & Telecommunications; National University of Defense Technology - China
  摘要：Photoinduced ultrafast multielectron transfer (m- ET) and long- lived charge- accumulated states in single molecules hold promise for light- energy conversion and utilization. However, compared to single- electron transfer (s- ET), m- ET tends to be thermodynamically and kinetically unfavorable. Here, we construct a dumbbell- shaped fullerene- indacenodithiophene triad, IT2, modified with two C 60 units in the donor indacenodithiophene. Exciting the C 60 units, ultrafast m- ET occurs with a ti...
• A genetically encoded anomalous SAXS ruler to probe the dimensions of intrinsically disordered proteins AI翻译
  作者：Yu, Miao; Gruzinov, Andrey Yu.; Ruan, Hao; Scheidt, Tom; Chowdhury, Aritra; Giofre, Sabrina; Mohammed, Ahmed S. A.; Caria, Joana; Sauter, Paul F.; Svergun, Dmitri I.; Lemke, Edward A.
  作者单位：Johannes Gutenberg University of Mainz; Institute of Molecular Biology (IMB); European Molecular Biology Laboratory (EMBL); European Molecular Biology Laboratory (EMBL); Institute of Molecular Biology (IMB); Egyptian Knowledge Bank (EKB); Fayoum University
  摘要：Intrinsically disordered proteins (IDPs) adopt ensembles of rapidly fluctuating heterogeneous conformations, influencing their binding capabilities and supramolecular transitions. The primary conformational descriptors for understanding IDP ensembles-the radius of gyration (RG), measured by small- angle X- ray scattering (SAXS), and the root mean square (rms) end- to- end distance (RE), probed by fluorescent resonance energy transfer (FRET)-are often reported to produce inconsistent results re...
• The essential role of TTC28 in maintaining chromosomal stability via HSPA8 chaperone- mediated autophagy AI翻译
  作者：Zhang, Ge; Xiang, Meiyi; Gu, Liankun; Zhou, Jing; Zhang, Baozhen; Tian, Wei; Deng, Dajun
  作者单位：Ministry of Education - China
  摘要：There are three distinct forms of autophagy, namely, macroautophagy, microautophagy, and HSPA8 chaperone- mediated autophagy (CMA). While macroautophagy is widely recognized as a regulator of chromosomal instability (CIN) through various pathways, the contributions of CMA and microautophagy to CIN remain uncertain. TTC28, a conserved gene in vertebrates, is frequently mutated and down- regulated in numerous human cancers. This study presents findings demonstrating the interaction between human...
• Intracortical recordings reveal the neuronal selectivity for bodies and body parts in the human visual cortex AI翻译
  作者：Ramirez, Jesus Garcia; Vanhoyland, Michael; Murty, N. A. Ratan; Decramer, Thomas; Van Paesschen, Wim; Bracci, Stefania; op de Beeck, Hans; Kanwisher, Nancy; Janssen, Peter; Theys, Tom
  作者单位：KU Leuven; KU Leuven; KU Leuven; University Hospital Leuven; Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); KU Leuven; University of Trento; KU Leuven
  摘要：Body perception plays a fundamental role in social cognition. Yet, the neural mechanisms underlying this process in humans remain elusive given the spatiotemporal constraints of functional imaging. Here, we present intracortical recordings of single- and multiunit spiking activity in two epilepsy surgery patients in or near the extrastriate body area, a critical region for body perception. Our recordings revealed a strong preference for human bodies over a large range of control stimuli. Notab...
• Proteome- wide bioinformatic annotation and functional validation of the monotopic phosphoglycosyl transferase superfamily AI翻译
  作者：Durand, Theo; Dodge, Greg J.; Siuda, Roxanne P.; Higinbotham, Hugh R.; Arbour, Christine A.; Ghosh, Soumi; Allen, Karen N.; Imperiali, Barbara
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT); Imperial College London; Biogen; Boston University; Boston University
  摘要：Phosphoglycosyl transferases (PGTs) are membrane proteins that initiate glycoconjugate biosynthesis by transferring a phospho-sugar moiety from a soluble nucleoside diphosphate sugar to a membrane- embedded polyprenol phosphate acceptor. The centrality of PGTs in complex glycan assembly and the current lack of functional information make these enzymes high- value targets for biochemical investigation. In particular, the small monotopic PGT family is exclusively bacterial and represents the min...
• A widespread family of ribosomal peptide metallophores involved in bacterial adaptation to metal stress AI翻译
  作者：Leprevosta, Laura; Jungerb, Sophie; Lippensc, Guy; Guillaumeb, Celine; Sicolid, Giuseppe; Oliveirae, Lydie; Oliveirae, Enrico; Falconef, Enrico; de Santis, Emiliano; Millot, Alex Rivera-; Billon, Gabriel; Stellato, Francesco; Henry, Celine; Antoine, Rudy; Zirah, Severine; Dubiley, Svetlana; Li, Yanyan; Jacob- Dubuisson, Francoise
  作者单位：Pasteur Network; Universite de Lille; Institut Pasteur Lille; Institut National de la Sante et de la Recherche Medicale (Inserm); Centre National de la Recherche Scientifique (CNRS); CHU Lille; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Ecology & Environment (INEE); Museum National d'Histoire Naturelle (MNHN); Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National des Sciences Appliquees de Toulouse; INRAE; Centre National de la Recherche Scientifique (CNRS); Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); Universite de Lille; AgroParisTech; Universite Paris Saclay; INRAE; Universite Federale Toulouse Midi-Pyrenees (ComUE); Universite de Toulouse; Institut National Polytechnique de Toulouse; Centre National de la Recherche Scientifique (CNRS); CNRS - Institute of Chemistry (INC); University of Rome Tor Vergata; Istituto Nazionale di Fisica Nucleare (INFN); University of Quebec; Institut national de la recherche scientifique (INRS)
  摘要：Ribosomally synthesized and posttranslationally modified peptides (RiPPs) are a structurally diverse group of natural products that bacteria employ in their survival strategies. Herein, we characterized the structure, the biosynthetic pathway, and the mode of action of a RiPP family called bufferins. With thousands of homologous biosynthetic gene clusters throughout the bacterial phylogenetic tree, bufferins form by far the largest family of RiPPs modified by multinuclear nonheme iron- depende...
• Identification of large polarons and exciton polarons in rutile and anatase polymorphs of titanium dioxide AI翻译
  作者：Dai, Zhenbang; Giustino, Feliciano
  作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin
  摘要：Titanium dioxide (TiO2) is a wide-gap semiconductor with numerous applications in photocatalysis, photovoltaics, and neuromorphic computing. The unique functional properties of this material critically depend on its ability to transport charge in the form of polarons, namely narrow electron wavepackets accompanied by local distortions of the crystal lattice. It is currently well established that the most important polymorphs of TiO2, the rutile and anatase phases, harbor small electron polaron...
• KCTD10 p.C124W variant contributes to schizophrenia by attenuating LLPS- mediated synapse formation AI翻译
  作者：Mu, Chenjun; Liu, Pan; Liu, Liang; Wang, Yaqing; Liu, Kefu; Li, Xiangyu; Li, Guozhong; Cheng, Jianbo; Bu, Mengyao; Chen, Han; Tang, Manpei; Yao, Yuanhang; Guan, Jun; Ma, Tiantian; Zhou, Zhengrong; Wu, Qingfeng; Li, Jiada; Guo, Hui; Xia, Kun; Hu, Zhengmao; Peng, Xiaoqing; Lang, Bing; Li, Faxiang; Chen, Xiao - wei; Xu, Zhiheng; Yuan, Ling
  作者单位：Central South University; Capital Medical University; Chinese Academy of Sciences; Institute of Genetics & Developmental Biology, CAS; Peking University; Shantou University; Central South University; Central South University
  摘要：KCTD10, a member of the potassium channel tetramerization domain (KCTD) family, is implicated in neuropsychiatric disorders and functions as a substrate recognition component within the RING- type ubiquitin ligase complex. A rare de novo variant of KCTD10, p.C124W, was identified in schizophrenia cases, yet its underlying pathogenesis remains unexplored. Here, we demonstrate that heterozygous KCTD10 C124W mice display pronounced synaptic abnormalities and exhibit schizophrenia- like behaviors....