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作者：Hamilton, Rebecca; Amano, Noel; Bradshaw, Corey J. A.; Saltre, Frederik; Patalano, Robert; Penny, Dan; Stevenson, Janelle; Wolfhagen, Jesse; Roberts, Patrick
作者单位：Max Planck Society; Max Planck Society; University of Sydney; Flinders University South Australia; Bryant University; Australian National University; Purdue University System; Purdue University; University of the Philippines System; University of the Philippines Diliman
摘要：The dominant paradigm is that large tracts of Southeast Asia's lowland rainforests were replaced with a savanna corridor during the cooler, more seasonal climates of the Last Glacial Maximum (LGM) (23,000 to 19,000 y ago). This interpretation has implications for understanding the resilience of Asia's tropical forests to projected climate change, implying a vulnerability to savannization. A savanna corridor is also an important foundation for archaeological interpretations of how humans moved ...
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作者：Hasan-Aslih, Siwar; Idan, Orly; Willer, Robb; Halperin, Eran
作者单位：Stanford University; Reichman University; Hebrew University of Jerusalem
摘要：In ethnically and linguistically diverse societies, disadvantaged groups often face pressures to acquire and speak the advantaged group's language to achieve social inclusion and economic mobility. This work investigates how using the advantaged group's language affects disadvantaged group members' in -group pride and collective self- esteem, relative to using their native language. Across six experimental studies involving Palestinian citizens of Israel (total N = 1,348), we test two competin...
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作者：Yang, Xu; Lia, Guilin; Loud, Pengbo; Zhang, Mingxin; Yao, Kai; Xiao, Jintao; Chen, Yiqian; Xu, Jiuzhi; Tian, Shengyuan; Deng, Min; Pan, Yuwei; Li, Mengzhen; Wu, Xi; Liu, Ruiqi; Shi, Xiaojing; Tian, Yuhua; Yu, Lu; Ke, Hao; Jiao, Baowei; Cong, Yingzi; Plikus, Maksim V.; Liu, Xiaowei; Yu, Zhengquan; Lv, Cong
作者单位：Zhengzhou University; China Agricultural University; Ankang University; Central South University; Chinese Academy of Sciences; Kunming Institute of Zoology, CAS; Northwestern University; Feinberg School of Medicine; University of California System; University of California Irvine; China Agricultural University
摘要：Oxidative stress, which can be activated by a variety of environmental risk factors, has been implicated as an important pathogenic factor for inflammatory bowel disease (IBD). However, how oxidative stress drives IBD onset remains elusive. Here, we found that oxidative stress was strongly activated in inflamed tissues from both ulcerative colitis patients and Crohn's disease patients, and it caused nuclear-to-cytosolic TDP-43 transport and a reduction in the TDP-43 protein level. To investiga...
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作者：da Silva, Jack
作者单位：University of Adelaide
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作者：Lauwers, Yoline; De Groof, Timo W. M.; Vincke, Cecile; Van Craenenbroeck, Jolien; Jumapili, Neema Ahishakiye; Barthelmess, Romina Mora; Courtoy, Guillaume; Waelput, Wim; De Pauw, Tessa; Raes, Geert; Devoogdt, Nick; Van Ginderachter, Jo A.
作者单位：Vrije Universiteit Brussel; Flanders Institute for Biotechnology (VIB); Vrije Universiteit Brussel; University Hospital Brussels; Vrije Universiteit Brussel; Universite Catholique Louvain; Cliniques Universitaires Saint-Luc; Vrije Universiteit Brussel
摘要：Immunotherapies have emerged as an effective treatment option for immune- related diseases, such as cancer and inflammatory diseases. However, variations in patient responsiveness limit the broad applicability and success of these immunotherapies. Noninvasive whole- body imaging of the immune status of individual patients during immunotherapy could enable the prediction and monitoring of the patient's response, resulting in more personalized treatments. In this study, we developed a nanobody-b...
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作者：Li, Gen; Liu, Ting; Xie, Wangliang; Liu, Zhenzhen; Li, Huixin; Whalen, Joann K.; Jousset, Alexandre; Wei, Zhong
作者单位：Nanjing Agricultural University; McGill University; Mohammed VI Polytechnic University
摘要：Predator-prey interactions are a major driver of microbiome dynamics, but remain difficult to predict. While several prey traits potentially impact resistance to predation, their effects in a multispecies context remain unclear. Here, we leverage synthetic bacterial communities of varying complexity to identify traits driving palatability for nematodes, a main consumer of bacteria in soil. We assessed trophic interactions between four nematode species and 122 bacterial isolates, across a gradi...
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作者：Ruperti, Fabian; Dzieciatkowska, Monika; Pankey, M. Sabrina; Asensio, Cedric S.; Anselmetti, Dario; Fernandez-Busquets, Xavier; Nichols, Scott A.
作者单位：European Molecular Biology Laboratory (EMBL); University of Colorado System; University of Colorado Anschutz Medical Campus; University System Of New Hampshire; University of New Hampshire; University of Denver; University of Bielefeld; ISGlobal; University of Barcelona; Hospital Clinic de Barcelona; University of Barcelona; Barcelona Institute of Science & Technology; Institut de Bioenginyeria de Catalunya
摘要：The discovery that sponges (Porifera) can fully regenerate from aggregates of dissociated cells launched them as one of the earliest experimental models to study the evolution of cell adhesion and allorecognition in animals. This process depends on an extracellular glycoprotein complex called the Aggregation Factor (AF), which is composed of proteins thought to be unique to sponges. We used quantitative proteomics to identify additional AF components and interacting proteins in the classical m...
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作者：Sinha, Abhipsa; Saini, Krishan Kumar; Chandramouli, Aakash; Tripathi, Kiran; Khan, Muqtada Ali; Satrusal, Saumya Ranjan; Verma, Ayushi; Mandal, Biswajit; Rai, Priyanka; Meena, Sanjeev; Nengroo, Mushtaq Ahmad; Singh, Manish Pratap; Bhushan, Namratha Shashi; Vasudevan, Madavan; Singhai, Atin; Singh, Kulranjan; Mishra, Anand Kumar; Kamat, Siddhesh S.; Datta, Dipak
作者单位：Council of Scientific & Industrial Research (CSIR) - India; CSIR - Central Drug Research Institute (CDRI); Academy of Scientific & Innovative Research (AcSIR); Indian Institute of Science Education & Research (IISER) Pune; King George's Medical University; King George's Medical University
摘要：Triple- negative breast cancer (TNBC) has profound unmet medical need globally for its devastating clinical outcome associated with rapid metastasis and lack of targeted therapies. Recently, lipid metabolic reprogramming especially fatty acid oxidation (FAO) has emerged as a major driver of breast cancer metastasis. Analyzing the expression of major FAO regulatory genes in breast cancer, we found selective overexpression of acyl-CoA synthetase 4 (ACSL4) in TNBC, which is primarily attributed t...
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作者：Zeng, Hai Yue; Deng, Shiyu; Jin, Congcong; Shang, Zhiyun; Chang, Le; Wang, Jiajun; Han, Xue; Wang, Ao; Jin, Dan; Wang, Yubo; He, Hang; Li, Lanxin; Deng, Xing Wang; Wei, Ning
作者单位：Southwest University - China; Peking University; Peking University; Peking University; Peking University; China Agricultural University; Southwest University - China
摘要：The classical acid growth theory suggests that auxin stimulates cell expansion by triggering apoplast acidification via plasma membrane (PM)- localized H+- ATPase. Here, we reconstructed the origin and evolutionary history of auxin- mediated acid growth. Comparative phylogenomic analysis showed that most core components of acid growth originated in Charophyta and then underwent subclass expansion and functional innovation during plant terrestrialization. In Charophyceae algae Chara braunii, we...
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作者：Cheung, Eric C.; Strathdee, Douglas; Stevenson, David; Coomes, Jack; Blyth, Karen; Vousden, Karen H.
作者单位：Francis Crick Institute; University of Glasgow
摘要：The consequences of reactive oxygen species (ROS) in cancer cells are complex and have been shown to both promote and retard tumorigenesis in different models. In mouse models of pancreatic ductal adenocarcinoma (PDAC), loss of the antioxidant defense gene Tigar results in both a reduction in the development of early pancreatic intraepithelial neoplasia and an increase in invasive and metastatic capacity, accompanied by decreased survival of mice lacking pancreatic TIGAR. We previously demonst...
