The extension of mammalian pregnancy required taming inflammation: Independent evolution of extended placentation in the tammar wallaby

• 成果类型: Article
• 署名作者: Dudley, Jessica S.; Renfree, Marilyn B.; Wagner, Guenter P.; Griffith, Oliver W.
• 署名单位: Macquarie University; University of Melbourne; Yale University; Yale University; University of Vienna
• 刊物名称: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• ISSN/ISSBN: 0027-10430
• DOI: 10.1073/pnas.2310047121
• 发表日期: 2024-10-15
• 关键词: macropus-eugenii macropodidae; short-tailed opossum; cystatin-c; differential expression; vascular-permeability; embryo implantation; immune-system; growth-factor; cathepsin-b; cross-talk

摘要

In the first live- bearing mammals, pregnancy was likely short and ended with a brief period of inflammatory maternal-fetal interaction. This mode of reproduction has been retained in many marsupials. While inflammation is key to successful implantation in eutherians, a key innovation in eutherians is the ability to switch off this inflammation after it has been initiated. This extended period, in which inflammation is suppressed, likely allowed for an extended period of placentation. Extended placentation has evolved independently in one lineage of marsupials, the macropodids (wallabies and kangaroos), with placentation lasting beyond the 2 to 4 d seen in other marsupial taxa, which allows us to investigate the role of inflammation response after attachment in the extension of placentation in mammals. By comparing gene expression changes at attachment in three marsupial species, the tammar wallaby, opossum, and fat- tailed dunnart, we show that inflammatory attachment is an ancestral feature of marsupial implantation. In contrast in epitheliochorial placentation (e.g., pig), this study found no evidence of a distinct attachment- related reaction in wallabies. Instead, only a small number of inflammatory strategy than seen in eutherians.