A population genetic analysis of the nematode Strongyloides stercoralis in Asia shows that human infection is not a zoonosis from dogs
成果类型：
Article
署名作者：
Liu, Yuchen; Sarker, A. H. M. Raihan; Sripa, Banchob; Tangkawattana, Sirikachorn; Khieu, Virak; Nevin, William; Paterson, Steve; Viney, Mark
署名单位：
University of Liverpool; University of Chittagong; Khon Kaen University; Khon Kaen University; National Center Parasitology, Entomology & Malaria Control; Liverpool School of Tropical Medicine; Imperial College London; Royal Centre for Defence Medicine; University of Birmingham
刊物名称：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN/ISSBN：
0027-14030
DOI：
10.1073/pnas.2424630122
发表日期：
2025-07-22
关键词：
摘要：
Gut nematode worms are important parasites of people and other animals. The parasitic and is one of the soil- transmitted helminthiases, a WHO- defined neglected tropical disease. It has long been suggested that human S. stercoralis infection may be a zoonosis from dogs. We investigated this by whole genome sequence analysis of S. stercoralis from sympatric human and dog populations in Asia. We find that human- and dog- derived S. stercoralis have genetically distinct nuclear genomes, but we also find evidence of rare cross- infection. Analysis of the S. stercoralis mitochondrial genome reveals evidence of historical introgression between human- and dog- derived parasites. Based on these data, humans when people domesticated dogs, since when human- and dog- derived parasites have differentiated, but have not become separate species.