4期

最新文章

• A tough soft-hard interface in the human knee joint driven by multiscale toughening mechanisms AI翻译
  作者：Li, Wenyue; Wang, Xiaozhao; Mao, Renwei; Li, Dong; Meng, Hongxu; Zhang, Ru; Fang, Jinghua; Kang, Zhengzhong; Wu, Boxuan; Ma, Weiwei; Yao, Xudong; Xie, Chang; Li, Rui; Wang, Jin; Chen, Xiao; Pan, Xihao; Chen, Weiqiu; Duan, Wangping; Gao, Huajian; Ouyang, Hongwei
  作者单位：Zhejiang University; Liangzhu Laboratory; Zhejiang University; Zhejiang University; Zhejiang University; Zhejiang University; Nanyang Technological University; Zhejiang University; Zhejiang University; Shanxi Medical University; Tsinghua University
  摘要：Joining heterogeneous materials in engineered structures remains a significant challenge due to stress concentration at interfaces, which often leads to unexpected failures. Investigating the complex, multiscale- graded structures found in animal tissue provides valuable insights that can help address this challenge. The human meniscus root-bone interface is an exemplary model, renowned for its exceptional fatigue resistance, toughness, and interfacial adhesion properties throughout its lifesp...
• Death-receptor activation halts clathrin-dependent endocytosis (vol 103, pg 10283, 2006) AI翻译
  作者：Austin, Cary D.; Lawrence, David A.; Peden, Andrew A.; Varfolomeev, Eugene E.; Totpal, Klara; De Maziere, Ann M.; Klumperman, Judith; Arnott, David; Pham, Victoria; Scheller, Richard H.; Ashkenazi, Avi
• Evolution of complexity through regulatory variation at a single gene AI翻译
  作者：Ferreira, Mafalda S.
  作者单位：Stockholm University
• A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli AI翻译
  作者：Park, Sohee; Jeon, Wook - Jong; Lee, Yeseul; Lim, Chae Lim; Lee, Eunyeong; Oh, Han Byeol; Lee, Gyu Sung; Kwon, Oh Hyun; Ryu, Bumhan; Cho, Yong - Joon; Kim, Chung Sub; Yoon, Sung - il; Chung, Jeong Min; Cho, Hongbaek
  作者单位：Sungkyunkwan University (SKKU); Catholic University of Korea; Kangwon National University; Sungkyunkwan University (SKKU); Institute for Basic Science - Korea (IBS); Kangwon National University; Kangwon National University; Sungkyunkwan University (SKKU)
  摘要：Bacterial cell wall assembly and remodeling require activities of peptidoglycan (PG) hydrolases as well as PG synthases. In particular, the activity of DD- endopeptidases, which cleave the 4- 3 peptide crosslinks in PG, is essential for PG expansion in gram- negative bacteria. Maintaining optimal levels of DD- endopeptidases is critical for expanding PG without compromising its integrity. In Escherichia coli, the levels of major DD- endopeptidases, MepS and MepH, along with the lytic transglyc...
• Molecular glue for phycobilisome attachment to photosystem II in Synechococcus sp. PCC 7002 AI翻译
  作者：Zheng, Zhenggao; Li, Xinrui; Wei, Peijun; Zhang, Xueang; Zhang, Tianyi; Zhang, Zhengdong; Dong, Chunxia; Zhao, Jindong
  作者单位：Peking University; Chinese Academy of Sciences; Institute of Hydrobiology, CAS
  摘要：Phycobilisomes (PBS) are the major photosynthetic light- harvesting complexes in cyanobacteria and red algae. While the structures of PBS have been determined in atomic resolutions, how PBS are attached to the reaction centers of photosystems remains less clear. Here, we report that a linker protein (LcpA) is required for the attachment of PBS to photosystem II (PSII) in the cyanobacterium Synechococcus sp. PCC 7002. We also report that the PB-loop of PBS, which is located within the alpha-APC...
• The functional role of oscillatory dynamics in neocortical circuits: A computational perspective AI翻译
  作者：Effenberger, Felix; Carvalho, Pedro; Dubinin, Igor; Singer, Wolf
  作者单位：Max Planck Society
  摘要：The dynamics of neuronal systems are characterized by hallmark features such as oscillations and synchrony. However, it has remained unclear whether these characteristics are epiphenomena or are exploited for computation. Due to the challenge of selectively interfering with oscillatory network dynamics in neuronal systems, we simulated recurrent networks of damped harmonic oscillators in which oscillatory activity is enforced in each node, a choice well supported by experimental findings. When...
• Continental freshwater discharge influences sea surface salinity variability near world's megadeltas (vol 121, e2412551121, 2024) AI翻译
  作者：Khadim, Fahad K.; Getirana, Augusto; Bindlish, Rajat; Biswas, Nishan Kumar; Nie, Wanshu; Lahmers, Timothy M.; Kumar, Sujay V.
• Life sets off a cascade of machines AI翻译
  作者：Tlusty, Tsvi; Libchaber, Albert
  作者单位：Ulsan National Institute of Science & Technology (UNIST); Rockefeller University
  摘要：Life is invasive, occupying all physically accessible scales, stretching between almost nothing (protons, electrons, and photons) and almost everything (the whole biosphere). Motivated by seventeenth-century insights into this infinity, this paper proposes a language to discuss life as an infinite double cascade of machines making machines. Using this simplified language, we first discuss the micro-cascade proposed by Leibniz, which describes how the self-reproducing machine of the cell is bui...
• Variants in the SOX9 transactivation middle domain induce axial skeleton dysplasia and scoliosis AI翻译
  作者：Wang, Lianlei; Liu, Zhaoyang; Zhao, Sen; Xu, Kexin; Aceves, Valeria; Qiu, Cheng; Feng, Hong Colleen; Bian, Fangzhou; He, Jingyu; Song, Christina J.; Troutwine, Benjamin; Liu, Lian; Ma, Samuel; Niu, Yuchen; Wang, Shengru; Yuan, Suomao; Li, Xiaoxin; Zhao, Lina; Liu, Xinyu; Qiu, Guixing; Wu, Zhihong; Zhang, Terry Jianguo; Gray, Ryan S.; Wu, Nan
  作者单位：Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Peking Union Medical College Hospital; Shandong University; University of Southern California; University of Texas System; University of Texas Austin; University of Southern California; Chinese Academy of Medical Sciences - Peking Union Medical College; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College Hospital; Peking Union Medical College
  摘要：SOX9 is a crucial transcriptional regulator of cartilage development and homeostasis. Dysregulation of SOX9 is associated with a wide spectrum of skeletal disorders, including campomelic dysplasia, acampomelic campomelic dysplasia, and scoliosis. Yet how SOX9 variants contribute to the spectrum of axial skeletal disorders is not well understood. Here, we report four pathogenic variants of SOX9 identified in a cohort of patients with congenital vertebral malformations. We report a pathogenic mi...
• A carnitine transporter at the blood-brain barrier modulates sleep via glial lipid metabolism in Drosophila AI翻译
  作者：Avila, Ashley; Lewandowski, Ava S.; Li, Yongjun; Gui, Jesse; Lee, Kaeun A.; Yang, Zhenglang; Kim, Mari; Lyles, James T.; Man, Kai; Sehgal, Amita; Chandler, Joshua D.; Zhang, Shirley L.
  作者单位：Emory University; University of Pennsylvania; Howard Hughes Medical Institute; University of Pennsylvania; Emory University; Emory University; Children's Healthcare of Atlanta (CHOA)
  摘要：To regulate brain function, peripheral compounds must traverse the blood-brain barrier (BBB), an interface between the brain and the circulatory system. To determine whether specific transport mechanisms are relevant for sleep, we conducted a BBB- specific inducible RNAi knockdown (iKD) screen for genes affecting sleep in Drosophila. We observed reduced sleep with knockdown of solute carrier CG6126, a carnitine transporter, as determined by isotope flux. Our findings suggest that CG6126 regula...