4期

最新文章

• The evolution of signaling and monitoring in plant-fungal networks AI翻译
  作者：Scott, Thomas W.; Kiers, E. Toby; West, Stuart A.
  作者单位：University of Oxford; University of St Andrews; Vrije Universiteit Amsterdam
  摘要：Experiments have shown that when one plant is attacked by a pathogen or herbivore, this can lead to other plants connected to the same mycorrhizal network up- regulating their defense mechanisms. It has been hypothesized that this represents signaling, with attacked plants producing a signal to warn other plants of impending harm. We examined the evolutionary plausibility of this and other hypotheses theoretically. We found that the evolution of plant signaling about an attack requires restric...
• Supporting Information for Sutter et al., Electrochemical cofactor recycling of bacterial microcompartments (vol 121, e2414220121, 2024) AI翻译
  作者：Sutter, Markus; Utschig, Lisa M.; Niklas, Jens; Paul, Sathi; Kahan, Darren N.; Gupta, Sayan; Poluektov, Oleg G.; Ferlez, Bryan H.; Tefft, Nicholas M.; TerAvest, Michaela A.; Hickey, David P.; Vermaas, Josh V.; Ralston, Corie Y.; Kerfeld, Cheryl A.
• Antiviral Mx proteins have an ancient origin and widespread distribution among eukaryotes AI翻译
  作者：Langley, Caroline A.; Dietzen, Peter A.; Emerman, Michael; Tenthorey, Jeannette L.; Malik, Harmit S.
  作者单位：University of Washington; University of Washington Seattle; Fred Hutchinson Cancer Center; Fred Hutchinson Cancer Center; University of California System; University of California San Francisco; Howard Hughes Medical Institute; Fred Hutchinson Cancer Center
  摘要：Mx proteins, first identified in mammals, encode potent antiviral activity against a wide range of viruses. Mx proteins arose within the Dynamin superfamily of proteins (DSP), which mediate critical cellular processes, such as endocytosis and mitochondrial, plastid, and peroxisomal dynamics. Despite their crucial role, the evolutionary origins of Mx proteins are poorly understood. Through comprehensive phylogenomic analyses with progressively expanded taxonomic sampling, we demonstrate that Mx...
• The importance of IP6 for ADAR RNA- editing enzymes and antiviral defense AI翻译
  作者：Bass, Brenda L.; Ranganathan, Supraja
  作者单位：Utah System of Higher Education; University of Utah
• Identification of ARHGEF11 (PDZ- RhoGEF) as an in vivo regulator of synapses and cognition AI翻译
  作者：Bjornson, Kathryn J.; Kermath, Bailey A.; Cahill, Michael E.
  作者单位：University of Wisconsin System; University of Wisconsin Madison
  摘要：Given the influence of cognitive abilities on life outcomes, there is inherent value in identifying genes involved in controlling learning and memory. Further, cognitive dysfunction is a core feature of many neuropsychiatric disorders. Here, we use a combinatory in silico approach to identify human gene targets that will have an especially high likelihood of individually and directly impacting cognition. This broad and unbiased screen led to the specific identification of ARHGEF11, which encod...
• Reply to Boomsma: The evidence that eusociality evolved from monogamous ancestors is inconclusive AI翻译
  作者：Rees-Baylis, Ella; Pen, Ida; Kreider, Jan J.
  作者单位：University of Groningen; University of Bern
• Automating alloy design and discovery with physics-aware multimodal multiagent AI AI翻译
  作者：Ghafarollahi, Alireza; Buehler, Markus J.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：The design of new alloys is a multiscale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process that is typically slow and reserved for human experts. Machine learning can help accelerate this process, for instance, through the use of deep surrogate models that connect structural and chemical features to material properties, or vice versa. However, ...
• Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids AI翻译
  作者：Ghovanloo, Mohammad-Reza; Tyagi, Sidharth; Zhao, Peng; Waxman, Stephen G.
  作者单位：Yale University; Yale University; Yale University
  摘要：Pain impacts billions of people worldwide, but treatment options are limited and a spectrum of adverse effects. The search for safe and nonaddictive pain treatments led to a focus on key mediators of nociceptor excitability. Voltage- gated sodium channels in the peripheral nervous system-Nav1.7, Nav1.8, and Nav1.9-play cial roles in pain signaling. Among these, Nav1.8 has shown promise due to its recovery from inactivation and role in repetitive firing, with recent clinical studies viding proo...
• Abrupt transformation of West Greenland lakes following compound climate extremes associated with atmospheric rivers AI翻译
  作者：Saros, Jasmine E.; Hazukova, Vaclava; Northington, Robert M.; Huston, Grayson P.; Lamb, Avery; Birkel, Sean; Pereira, Ryan; Bourdin, Guillaume; Jiang, Binbin; Mcgowan, Suzanne
  作者单位：University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; Heriot Watt University; University of Maine System; University of Maine Orono; Zhejiang University of Science & Technology; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW)
  摘要：Arctic ecosystems are affected by accelerated warming as well as the intensification of the hydrologic cycle, yet understanding of the impacts of compound climate extremes (e.g., simultaneous extreme heat and rainfall) remains limited, despite their high potential to alter ecosystems. Here, we show that the aquatic ecosystems in historically arid West Greenland have undergone an ecological transformation after a series of atmospheric rivers that simultaneously produced record heat and rainfall...
• Diffusive topology preserving manifold distances for single-cell data analysis AI翻译
  作者：Wei, Jiangyong; Zhang, Bin; Wang, Qiu; Zhou, Tianshou; Tai, Tianhai; Chen, Luonan
  作者单位：Sun Yat Sen University; Monash University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS
  摘要：Manifold learning techniques have emerged as crucial tools for uncovering latent patterns in high-dimensional single-cell data. However, most existing dimensionality reduction methods primarily rely on 2D visualization, which can distort true data relationships and fail to extract reliable biological information. Here, we present DTNE (diffusive topology neighbor embedding), a dimensionality reduction framework that faithfully approximates manifold distance to enhance cellular relationships an...