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作者：Nakamura, Shun; Tanimura, Yukihiro; Nomura, Risa; Suzuki, Hiroshi; Nishikawa, Kouki; Kamegawa, Akiko; Numoto, Nobutaka; Tanaka, Atsushi; Kawabata, Shigeru; Sakaguchi, Shoichi; Emi, Akino; Suzuki, Youichi; Fujiyoshi, Yoshinori
作者单位：Okayama University; Osaka Medical & Pharmaceutical University; Osaka Medical & Pharmaceutical University; Osaka Medical & Pharmaceutical University
摘要：Pathogen mutations present an inevitable and challenging problem for therapeutics and the development of mutation- tolerant anti- infective drugs to strengthen global health and combat evolving pathogens is urgently needed. While spike proteins on viral surfaces are attractive targets for preventing viral entry, they mutate frequently, making it difficult to develop effective therapeutics. Here, we used a structure- guided strategy to engineer an inhibitor peptide against the SARS- CoV- 2 spik...
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作者：Priya, Manisha; Gupta, Sonu Kumar; Koundal, Anil; Kapoor, Srajan; Tiwari, Snigdha; Kidwai, Saqib; Carvalho, Luiz Pedro Sorio de; Thakur, Krishan Gopal; Mahajan, Dinesh; Sharma, Deepak; Kumar, Yashwant; Singh, Ramandeep
作者单位：Department of Biotechnology (DBT) India; Translational Health Science & Technology Institute (THSTI); Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Roorkee; Council of Scientific & Industrial Research (CSIR) - India; CSIR - Institute of Microbial Technology (IMTECH)
摘要：Itaconate, an abundant metabolite produced by macrophages upon interferon-gamma stimulation, possesses both antibacterial and immunomodulatory properties. Despite its crucial role in immunity and antimicrobial control, its mechanism of action and dissimilation are poorly understood. Here, we demonstrate that infection of mice with Mycobacterium tuberculosis increases itaconate levels in lung tissues. We also show that exposure to itaconate inhibits M. tuberculosis growth in vitro, in macrophag...
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作者：Wei, Xue-Xin; Woodford, Michael
作者单位：University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Columbia University
摘要：Measuring and interpreting errors in behavioral tasks is critical for understanding cognition. Conventional wisdom assumes that encoding/decoding errors for continuous variables in behavioral tasks should naturally have Gaussian distributions, so that deviations from normality in the empirical data indicate the presence of more complex sources of noise. This line of reasoning has been central for prior research on working memory. Here, we reassess this assumption and find that even in ideal ob...
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作者：Yang, Beibei; Guo, Yao; Liu, Lilong; Huang, Ting; Zhao, Bo; Bai, Wanyu; Zhang, Guigen; Zhu, Chengming; Dong, Junchao
作者单位：Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
摘要：The LIM- domain- only protein LMO2 interacts with LDB1 in context- dependent multiprotein complexes and plays key roles in erythropoiesis and T cell leukemogenesis, but whether they have any roles in B cells is unclear. Through a CRISPR/Cas9-based loss- of- function screening, we identified LMO2 and LDB1 as factors for class switch recombination (CSR) in murine B cells. LMO2 contributes to CSR at least in part by promoting end joining of DNA double- strand breaks (DSBs) and inhibiting end rese...
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作者：Duan, Yueran; Memon, Shahan Ali; Alshebli, Bedoor; Guan, Qing; Holme, Petter; Lrahwan, Tala
作者单位：China University of Geosciences; Aalto University; New York University; New York University Abu Dhabi; University of Washington; University of Washington Seattle; China University of Geosciences; Kobe University; New York University; New York University Abu Dhabi
摘要：Postdoctoral training is a career stage often described as a demanding and anxiety- laden time when many promising PhDs see their academic dreams slip away due to circumstances beyond their control. We use a unique dataset of academic publishing and careers to chart the more or less successful postdoctoral paths. We build a measure of academic success on the citation patterns two to five years into a faculty career. Then, we monitor how students' postdoc positions-in terms of relocation, chang...
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作者：Zhang, Yaqing; Wu, Rihan; Shahjahan, Md; Yang, Canchai; Pyeon, Dohun; Harel, Elad
作者单位：Michigan State University; Michigan State University
摘要：The natural vibrational frequencies of biological particles such as viruses and bacteria encode critical information about their mechanical and biological states as they interact with their local environment and undergo structural evolution. However, detecting and tracking these vibrations within a biological context at the single particle level has remained elusive. In this study, we track the vibrational motions of single, unlabeled virus particles under ambient conditions using ultrafast sp...
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作者：Biswas, Nilima; Mori, Tommaso; Nagaraj, Naresh Kumar Ragava Chetty; Xin, Hong; Diemer, Tanja; Li, Pin; Su, Yongxuan; Piermarocchi, Carlo; Ferrara, Napoleone
作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Michigan State University; University of California System; University of California San Diego; China Pharmaceutical University
摘要：We hypothesized that a strategy employing tissue- specific endothelial cells (EC) might facilitate the identification of tissue- or organ- specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water- soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4lym- phoma extracts. ADP stimulated the growth of bovine choroidal EC (BCEC) an...
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作者：Shen, Yidi; Samwer, Konrad; Johnson, William L.; Goddard III, William A.; An, Qi
作者单位：Iowa State University; California Institute of Technology; California Institute of Technology; University of Gottingen
摘要：From molecular dynamics (MD) simulations of melt-quenching and thermal aging procedures in pure Ag, Cu, Ag-Cu binaryalloys, and Cu-Zr binaryalloys, we have identified two distinct amorphous phases for a metastable undercooled liquid: the homogeneous L-phase with low shear rigidity and the heterogenous G-phase with much higher shear rigidity and a heterogeneity length scale Lambda. Here, we examine two- phase equilibration studies showing that the G- phase melts to form the L-phase above simila...
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作者：Sneideriene, Greta; Diaz, Alicia Gonzalez; Adhikari, Sourav Das; Wei, Jiapeng; Michaels, Thomas; Sneideris, Tomas; Linse, Sara; Vendruscolo, Michele; Garai, Kanchan; Knowles, Tuomas P. J.
作者单位：University of Cambridge; Tata Institute of Fundamental Research (TIFR); Swiss Federal Institutes of Technology Domain; ETH Zurich; Swiss Federal Institutes of Technology Domain; ETH Zurich; Lund University; University of Cambridge
摘要：The onset and development of Alzheimer's disease is linked to the accumulation of pathological aggregates formed from the normally monomeric amyloid-beta peptide within the central nervous system. These A beta aggregates are increasingly successfully targeted with clinical therapies at later stages of the disease, but the fundamental molecular steps in early stage disease that trigger the initial nucleation event leading to the conversion of monomeric A beta peptide into pathological aggregate...
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作者：van Schie, Janne J. M.; Brussee, Sem J.; Luijsterburg, Martijn S.
作者单位：Leiden University; Leiden University Medical Center (LUMC); Leiden University - Excl LUMC
