4期

最新文章

• Lateral olivocochlear neurons modulate cochlear responses to noise exposure AI翻译
  作者：Sitko, Austen A.; Frank, Michelle M.; Romero, Gabriel E.; Hunt, Mackenzie; Goodrich, Lisa, V
  作者单位：Harvard University; Harvard Medical School
  摘要：The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage- inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium. One population of OCNs, the lateral oliv...
• Complement C3 of tumor- derived extracellular vesicles promotes metastasis of RCC via recruitment of immunosuppressive myeloid cells AI翻译
  作者：Zhang, Yibi; Wang, Xiaodong; Gu, Yinmin; Liu, Tongfeng; Zhao, Xujie; Cheng, Shuwen; Duan, Liqiang; Huang, Chang; Wu, Songzhe; Gao, Shan
  作者单位：Chinese Academy of Sciences; University of Science & Technology of China, CAS; Chinese Academy of Sciences; Suzhou Institute of Biomedical Engineering & Technology, CAS; Southeast University - China; Southeast University - China; Guizhou University; Nanjing University
  摘要：Heterogeneous roles of complement C3 have been implicated in tumor metastasis and are highly context dependent. However, the underlying mechanisms linking C3 to tumor metastasis remain elusive in renal cell carcinoma (RCC). Here, we demonstrate that C3 of RCC cell- derived extracellular vesicles (EVs) contributes to metastasis via polarizing tumor- associated macrophages (TAMs) into the immunosuppressive phenotype and recruiting polymorphonuclear myeloid- derived suppressor cells (PMN- MDSCs)....
• Dispersal of influenza virus populations within the respiratory tract shapes their evolutionary potential AI翻译
  作者：Ferreri, Lucas M.; Seibert, Brittany; Caceres, C. Joaquin; Patatanian, Kayle; Holmes, Katie E.; Gay, L. Claire; Faccin, Flavio Cargnin; Cardenas, Matias; Carnaccini, Silvia; Shetty, Nishit; Rajao, Daniela; Koelle, Katia; Marr, Linsey C.; Perez, Daniel R.; Lowen, Anice C.
  作者单位：Emory University; University System of Georgia; University of Georgia; Virginia Polytechnic Institute & State University; Emory University
  摘要：Viral infections are characterized by dispersal from an initial site to secondary locations within the host. How the resultant spatial heterogeneity shapes within- host genetic diversity and viral evolutionary pathways is poorly understood. Here, we show that virus dispersal within and between the nasal cavity and trachea maintains diversity and is therefore conducive to adaptive evolution, whereas dispersal to the lungs gives rise to population heterogeneity. We infected ferrets either intran...
• Electrifying the brain capillary Ca2+ signal AI翻译
  作者：Navedo, Manuel F.; Nieves-Cintron, Madeline; Santana, L. Fernando
  作者单位：University of California System; University of California Davis; University of California System; University of California Davis
• Macromolecular interactions and geometrical confinement determine the 3D diffusion of ribosome-sized particles in live Escherichia coli cells AI翻译
  作者：Valverde-Mendez, Diana; Sunol, Alp M.; Bratton, Benjamin P.; Delarue, Morgan; Hofmann, Jennifer L.; Sheehan, Joseph P.; Gitai, Zemer; Holt, Liam J.; Shaevitz, Joshua W.; Zia, Roseanna N.
  作者单位：Princeton University; Princeton University; Stanford University; Princeton University; Vanderbilt University; Vanderbilt University; Universite de Toulouse; New York University
  摘要：The crowded bacterial cytoplasm is composed of biomolecules that span several orders of magnitude in size and electrical charge. This complexity has been proposed as the source of the rich spatial organization and apparent anomalous diffusion of intracellular components, although this has not been tested directly. Here, we use biplane microscopy to track the 3D motion of self-assembled bacterial genetically encoded multimeric nanoparticles (bGEMs) with tunable size (20 to 50 nm) and charge (-3...
• Correction for Zioga et al., Observed carbon decoupling of subnational production insufficient for net- zero goal by 2050 AI翻译
  作者：Zioga, Maria; Kotz, Maximilian; Levermann, Anders
• Valuing the benefits of reducing firearm violence in the United States AI翻译
  作者：Cook, Philip J.; Jeuland, Marc; Ludwig, Jens
  作者单位：Duke University; Duke University; University of Chicago
  摘要：Justifying a proposed government regulation intended to reduce firearm violence requires a conceptually sound estimate of the monetized value of that impact and how that value is distributed across the population. Some previous estimates do not serve as a valid basis for policy evaluation or are out of date. A nationally representative survey was conducted by the AP-NORC Center for Public Affairs Research in August 2022 (n = 660). The authors designed and added a series of contingent- valuatio...
• Adaptive evolutionary trajectories in complexity: Transitions between unicellularity and facultative differentiated multicellularity AI翻译
  作者：Isaksson, Hanna; Lind, Peter; Libby, Eric
  作者单位：Umea University; Umea University; Umea University; Umea University
  摘要：Multicellularity spans a wide gamut in terms of complexity, from simple clonal clusters of cells to large-scale organisms composed of differentiated cells and tissues. While recent experiments have demonstrated that simple forms of multicellularity can readily evolve in response to different selective pressures, it is unknown if continued exposure to those same selective pressures will result in the evolution of increased multicellular complexity. We use mathematical models to consider the ada...
• Reply to van Schie et al.: ARK2N in TCR: Across in vivo and in vitro studies AI翻译
  作者：Luo, Yefei; Li, Jia; Wang, Jiadong
  作者单位：Peking University
• Gesture counteracts gender stereotypes conveyed through subtle linguistic cues AI翻译
  作者：Qian, Yihan; Goldin, Susan; Bian, Lin
  作者单位：University of Chicago
  摘要：Despite increased attempts to express equality in speech, biases often leak out through subtle linguistic cues. For example, the subject-complement statement (SCS, Girls are as good as boys at math) is used to advocate for equality but often reinforces gender stereotypes (boys are the standard against which girls are judged). We ask whether stereotypes conveyed by SCS can be counteracted by gesture. Two preregistered studies with 8- to 11- y- old children (N = 320 total) investigate whether an...