4期

最新文章

• Exploring a unique class of flavoenzymes: Identification and biochemical characterization of ribosomal RNA dihydrouridine synthase ( vol 121, e2401981121, 2024) AI翻译
  作者：Toubdji, Sabrine; Thullier, Quentin; Kilz, Lea- Marie; Marchand, Virginie; Yuan, Yifeng; Sudol, Claudia; Goyenvalle, Catherine; Jean-Jean, Olivier; Rose, Simon; Douthwaite, Stephen; Hardy, Leo; Baharoglu, Zeynep; de Crecy-Lagard, Valerie; Helm, Mark; Motorin, Yuri; Hamdane, Djemel; Bregeon, Damien
• Molecular mechanism of ligand recognition and activation of lysophosphatidic acid receptor LPAR6 AI翻译
  作者：Duan, Yaning; Xu, Zhenmei; Hao, Boyu; Zhang, Anqi; Guo, Changyou; He, Yuanzheng
  作者单位：Harbin Institute of Technology; Harbin Institute of Technology
  摘要：Lysophosphatidic acid (LPA) exerts its physiological roles through the endothelialdifferentiation gene (EDG) family LPA receptors (LPAR1-3) or the non-EDG family LPA receptors (LPAR4-6). LPAR6 plays crucial roles in hair loss and cancer progression, yet its structural information is very limited. Here, we report the cryoelectron microscopy structure of LPA-bound human LPAR6 in complex with a mini G13 or Gq protein. These structures reveal a distinct ligand binding and recognition mode that dif...
• Correction for Thompson and Fronhofer, The conflict between adaptation and dispersal for maintaining biodiversity in changing environments (vol 116, pg 21061, 2019) AI翻译
  作者：Thompson, Patrick L.; Fronhofer, Emanuel A.
• Maternal manipulation in the social Hymenoptera AI翻译
  作者：Boomsma, Jacobus J.
  作者单位：University of Copenhagen
• Hidden artistic complexity of Peru's Chancay culture discovered in tattoos by laser- stimulated fluorescence AI翻译
  作者：Kaye, Thomas G.; Bak, Judyta; Marcelo, Henry William; Pittman, Michael
  作者单位：Jagiellonian University; Chinese University of Hong Kong; University of London; University College London
  摘要：Tattoos were a prevalent art form in pre- Hispanic South America exemplified by mummified human remains with preserved skin decoration that reflects the personal and cultural representations of their times. Tattoos are known to fade and bleed over time and this is compounded in mummies by the decay of the body, inhibiting the ability to examine the original art. Laser- stimulated fluorescence (LSF) produces images based on fluorescence emitted from within the target. Here, we present the first...
• BCL6 coordinates muscle mass homeostasis with nutritional states AI翻译
  作者：Wang, Hui J.; Fan, Weiwei; Liu, Sihao; Kim, Kyeongkyu; Matsushima, Ayami; Ogawa, Satoshi; Kang, Hyun Gyu; Zhu, Jonathan; Estepa, Gabriela; He, Mingxiao; Crossley, Lillian; Liddle, Christopher; Kim, Minseok S.; Truitt, Morgan L.; Yu, Ruth T.; Atkins, Annette R.; Downes, Michael; Evans, Ronald M.
  作者单位：Salk Institute; Kyushu University; University of Sydney; Westmead Institute for Medical Research; University of Sydney; Daegu Gyeongbuk Institute of Science & Technology (DGIST)
  摘要：Nutritional status is a determining factor for growth during development and homeostatic maintenance in adulthood. In the context of muscle, growth hormone (GH) coordinates growth with nutritional status; however, the detailed mechanisms remain to be fully elucidated. Here, we show that the transcriptional repressor B cell lymphoma deletion of BCL6 at either perinatal or adult stages profoundly reduces muscle mass and compromises muscle strength. Conversely, muscle- directed viral overexpressi...
• Intercellular mRNA transfer alters the human pluripotent stem cell state AI翻译
  作者：Yoneyama, Yosuke; Zhang, Ran-Ran; Maezawa, Mari; Masaki, Hideki; Kimura, Masaki; Cai, Yuqi; Adam, Mike; Parameswaran, Sreeja; Mizuno, Naoaki; Bhadury, Joydeep; Maezawa, So; Ochiai, Hiroshi; Nakauchi, Hiromitsu; Potter, S. Steven; Weirauch, Matthew T.; Takebe, Takanori
  作者单位：University of Osaka; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; Cincinnati Children's Hospital Medical Center; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center; Stanford University; Tokyo University of Science; Kyushu University; University System of Ohio; University of Cincinnati; Cincinnati Children's Hospital Medical Center
  摘要：Intercellular transmission of messenger RNA (mRNA) is being explored in mammalian species using immortal cell lines. Here, we uncover an intercellular mRNA transfer phenomenon that allows for the adaptation and reprogramming of human primed pluripotent stem cells (hPSCs). This process is induced by the direct cell contact- mediated coculture with mouse embryonic stem cells under the condition impermissible for primed hPSC culture. Mouse- derived mRNA contents are transmitted into adapted hPSCs...
• Light signal regulates endoreduplication and tomato fruit expansion through the SlPIF1a-SlTLFP8-SlCDKB2 module AI翻译
  作者：Zhang, Jiaojiao; Xu, Jiayi; Wang, Xinman; Liu, Ying; Li, Shuangtao; Zhang, Jialong; He, Lingfeng; Guo, Luqin; Li, Chonghua; Li, Xin - Xu; Guo, Yang - Dong; Zhang, Na
  作者单位：China Agricultural University; Hebei Normal University of Science & Technology; Shanghai Academy of Agricultural Sciences; Beijing Academy of Agriculture & Forestry Sciences (BAAFS)
  摘要：Light serves as an energy source for cell division and expansion during fruit development. Cell expansion significantly influences fruit size and is closely linked to endoreduplication, a unique cell cycle variation characterized by DNA replication without cytokinesis. Paradoxically, under conditions of ample photosynthates, light signaling suppresses cell expansion. The intricate regulation of endoreduplication in response to light signaling during fruit development has remained an intriguing...
• Adenosine diphosphate stimulates VEGF- independent choroidal endothelial cell proliferation: A potential escape from anti-VEGF therapy AI翻译
  作者：Biswas, Nilima; Mori, Tommaso; Nagaraj, Naresh Kumar Ragava Chetty; Xin, Hong; Diemer, Tanja; Li, Pin; Su, Yongxuan; Piermarocchi, Carlo; Ferrara, Napoleone
  作者单位：University of California System; University of California San Diego; University of California System; University of California San Diego; Michigan State University; University of California System; University of California San Diego; China Pharmaceutical University
  摘要：We hypothesized that a strategy employing tissue- specific endothelial cells (EC) might facilitate the identification of tissue- or organ- specific vascular functions of ubiquitous metabolites. An unbiased approach was employed to identify water- soluble small molecules with mitogenic activity on choroidal EC. We identified adenosine diphosphate (ADP) as a candidate, following biochemical purification from mouse EL4lym- phoma extracts. ADP stimulated the growth of bovine choroidal EC (BCEC) an...
• Metabolic activity controls the emergence of coherent flows in microbial suspensions AI翻译
  作者：Fragkopoulos, Alexandros A.; Boehme, Florian; Drewes, Nicole; Baeumchen, Oliver
  作者单位：University of Bayreuth; Max Planck Society
  摘要：Photosynthetic microbes have evolved and successfully adapted to the ever-changing environmental conditions in complex microhabitats throughout almost all ecosystems on Earth. In the absence of light, they can sustain their biological functionalities through aerobic respiration, and even in anoxic conditions through anaerobic metabolic activity. For a suspension of photosynthetic microbes in an anaerobic environment, individual cellular motility is directly controlled by its photosynthetic act...