4期

最新文章

• Cortical reorganization following dorsal spinal injuries in newborn monkeys reveals a critical period in the development of the somatosensory cortex AI翻译
  作者：Jain, Neeraj; Qi, Hui- Xin; Raman, Arun; Lyon, David; Kaas, Jon H.
  作者单位：Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Jodhpur; Vanderbilt University; Department of Biotechnology (DBT) India; National Brain Research Centre (NBRC); University of California System; University of California Irvine
  摘要：Lesions of the dorsal columns of the spinal cord in adult macaque monkeys lead to the loss of hand inputs and large- scale expansion of the face inputs in the hand region of the somatosensory cortex. Inputs from alternate spinal pathways do not reactivate the deafferented regions of area 3b. Here, we determined how transections of the dorsal columns done within a few days after birth affect the developing somatosensory cortex. Dorsal columns were transected between the 3rd and 12th postnatal d...
• Multiorifice acoustic microrobot for boundary- free multimodal 3D swimming AI翻译
  作者：Mahkam, Nima; Ugurlu, Musab C.; Kalva, Sandeep Kumar; Aghakhani, Amirreza; Razansky, Daniel; Sitti, Metin
  作者单位：Max Planck Society; Swiss Federal Institutes of Technology Domain; ETH Zurich; University of Geneva; University of Zurich; University of Stuttgart; Koc University; Koc University; Indian Institute of Technology System (IIT System); Indian Institute of Technology (IIT) - Bombay
  摘要：The emerging new generation of small- scaled acoustic microrobots is poised to expedite the adoption of microrobotics in biomedical research. Recent designs of these microrobots have enabled intricate bioinspired motions, paving the way for their real- world applications. We present a multiorifice design of air- filled spherical microrobots that convert acoustic wave energy to efficient propulsion through a resonant encapsulated microbubble. These microrobots can swim boundary- free in three- ...
• Band asymmetry-driven nonreciprocal electronic transport in a helimagnetic semimetal α-EuP3 AI翻译
  作者：Mayo, Alex Hiro; Deaconu, Darius - Alexandru; Masuda, Hidetoshi; Nii, Yoichi; Takahashi, Hidefumi; Belosludov, Rodion Vladimirovich; Ishiwata, Shintaro; Bahramy, Mohammad Saeed; Onose, Yoshinori
  作者单位：Tohoku University; University of Manchester; University of Osaka
  摘要：Chiral magnetic textures give rise to unconventional magnetotransport phenomena such as the topological Hall effect and nonreciprocal electronic transport. While the correspondence between topology or symmetry of chiral magnetic structures and such transport phenomena has been well established, a microscopic understanding based on the spin- dependent band structure in momentum space remains elusive. Here, we demonstrate how a chiral magnetic superstructure introduces an asymmetry in the electr...
• Falling racial inequality and rising educational inequality in US prison admissions for drug, violent, and property crimes AI翻译
  作者：Muller, Christopher; Roehrkasse, Alexander F.
  作者单位：Harvard University; Butler University; Cornell University
  摘要：Using administrative and survey data, we show that there has been a sea change in the contours of American imprisonment. At the end of the twentieth century, inequality in the prison admission rates of Black and White Americans was comparable to inequality in the prison admission rates of people with and without a college education. However, educational inequality is now much greater than racial inequality in prison admissions for all major crime types. Violent offenses have replaced drug offe...
• Hydrated cable bacteria exhibit protonic conductivity over long distances AI翻译
  作者：Lusk, Bradley G.; Morgan, Sheba; Mulvaney, Shawn P.; Blue, Brandon; Lagasse, Sam W.; Cress, Cory D.; Bjerg, Jesper T.; Lee, Woo K.; Eddie, Brian J.; Robinson, Jeremy T.
  作者单位：United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; United States Department of Defense; United States Navy; United States Naval Research Laboratory; Aarhus University; United States Department of Defense; United States Navy; United States Naval Research Laboratory
  摘要：This study presents the direct measurement of proton transport along filamentous Desulfobulbaceae, or cable bacteria. Cable bacteria are filamentous multicellular microorganisms that have garnered much interest due to their ability to serve as electrical conduits, transferring electrons over several millimeters. Our results indicate that cable bacteria can also function as protonic conduits because they contain proton wires that transport protons at distances >100 mu m. We find that protonic c...
• Behavioral nudges prevent loan delinquencies at scale: A 13-million- person field experiment AI翻译
  作者：Kuan, Robert; Blagg, Kristin; Castleman, Benjamin L.; Darolia, Rajeev; Matsudaira, Jordan D.; Milkman, Katherine L.; Turner, Lesley J.
  作者单位：University of Pennsylvania; Urban Institute; University of Virginia; US Department of Education; University of Kentucky; American University; University of Chicago
  摘要：Americans collectively hold over $1.6 trillion in student loan debt, and over the last decade millions of borrowers have defaulted on loans, with serious consequences for their financial health. In a 13- million- person field experiment with the U.S. Department of Education, we tested the effectiveness of different email interventions to inform borrowers about alternative repayment options after a missed loan payment. Our interventions tested whether sending monthly behaviorally- informed emai...
• Automating alloy design and discovery with physics-aware multimodal multiagent AI AI翻译
  作者：Ghafarollahi, Alireza; Buehler, Markus J.
  作者单位：Massachusetts Institute of Technology (MIT); Massachusetts Institute of Technology (MIT)
  摘要：The design of new alloys is a multiscale problem that requires a holistic approach that involves retrieving relevant knowledge, applying advanced computational methods, conducting experimental validations, and analyzing the results, a process that is typically slow and reserved for human experts. Machine learning can help accelerate this process, for instance, through the use of deep surrogate models that connect structural and chemical features to material properties, or vice versa. However, ...
• Nav1.8, an analgesic target for nonpsychotomimetic phytocannabinoids AI翻译
  作者：Ghovanloo, Mohammad-Reza; Tyagi, Sidharth; Zhao, Peng; Waxman, Stephen G.
  作者单位：Yale University; Yale University; Yale University
  摘要：Pain impacts billions of people worldwide, but treatment options are limited and a spectrum of adverse effects. The search for safe and nonaddictive pain treatments led to a focus on key mediators of nociceptor excitability. Voltage- gated sodium channels in the peripheral nervous system-Nav1.7, Nav1.8, and Nav1.9-play cial roles in pain signaling. Among these, Nav1.8 has shown promise due to its recovery from inactivation and role in repetitive firing, with recent clinical studies viding proo...
• Abrupt transformation of West Greenland lakes following compound climate extremes associated with atmospheric rivers AI翻译
  作者：Saros, Jasmine E.; Hazukova, Vaclava; Northington, Robert M.; Huston, Grayson P.; Lamb, Avery; Birkel, Sean; Pereira, Ryan; Bourdin, Guillaume; Jiang, Binbin; Mcgowan, Suzanne
  作者单位：University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; University of Maine System; University of Maine Orono; Heriot Watt University; University of Maine System; University of Maine Orono; Zhejiang University of Science & Technology; Royal Netherlands Academy of Arts & Sciences; Netherlands Institute of Ecology (NIOO-KNAW)
  摘要：Arctic ecosystems are affected by accelerated warming as well as the intensification of the hydrologic cycle, yet understanding of the impacts of compound climate extremes (e.g., simultaneous extreme heat and rainfall) remains limited, despite their high potential to alter ecosystems. Here, we show that the aquatic ecosystems in historically arid West Greenland have undergone an ecological transformation after a series of atmospheric rivers that simultaneously produced record heat and rainfall...
• Diffusive topology preserving manifold distances for single-cell data analysis AI翻译
  作者：Wei, Jiangyong; Zhang, Bin; Wang, Qiu; Zhou, Tianshou; Tai, Tianhai; Chen, Luonan
  作者单位：Sun Yat Sen University; Monash University; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Chinese Academy of Sciences; Center for Excellence in Molecular Cell Science, CAS
  摘要：Manifold learning techniques have emerged as crucial tools for uncovering latent patterns in high-dimensional single-cell data. However, most existing dimensionality reduction methods primarily rely on 2D visualization, which can distort true data relationships and fail to extract reliable biological information. Here, we present DTNE (diffusive topology neighbor embedding), a dimensionality reduction framework that faithfully approximates manifold distance to enhance cellular relationships an...