4期

最新文章

• Tree rings and Earth System Models unveil mid- Holocene alpine climate AI翻译
  作者：Bunn, Andrew G.
  作者单位：Western Washington University
• Co- option of mitochondrial nucleic acid-sensing pathways by HSV-1 UL12.5 for reactivation from latent infection AI翻译
  作者：Krakowiak, Patryk A.; Flores, Matthew E.; Cuddy, Sean R.; Whitford, Abigail L.; Dochnal, Sara A.; Babnis, Aleksandra; Miyake, Tsuyoshi; Tigano, Marco; Engel, Daniel A.; Cliffe, Anna R.
  作者单位：University of Virginia; University of Virginia; Thomas Jefferson University; University of California System; University of California San Diego
  摘要：Although viruses subvert innate immune pathways for their replication, there is evidence they can also co- opt antiviral responses for their benefit. The ubiquitous human pathogen, Herpes simplex virus- 1 (HSV- 1), encodes a protein (UL12.5) that induces the release of mitochondrial nucleic acid into the cytosol, which activates immune- sensing pathways and reduces productive replication in nonneuronal cells. HSV- 1 establishes latency in neurons and can reactivate to cause disease. We found t...
• Advancing forecasting capabilities: A contrastive learning model for forecasting tropical cyclone rapid intensification AI翻译
  作者：Wang, Chong; Yang, Nan; Li, Xiaofeng
  作者单位：Chinese Academy of Sciences; Institute of Oceanology, CAS; Chinese Academy of Sciences; Institute of Oceanology, CAS
  摘要：Tropical cyclones (TCs), particularly those that rapidly intensify (RI), pose a significant threat due to the uncertainty in forecasting them. RI TC periods, which intensify by at least 13 m/s within 24 h, remain challenging to forecast accurately. Existing models achieve a probability of detection (POD) of 82.6% and a false alarm rate (FARate) of 27.2%. To address this, we developed a contrastive- based RI TC forecasting (RITCF- contrastive) model, utilizing satellite infrared imagery alongsi...
• Epstein-Barr virus BALF0/1 subverts the Caveolin and ERAD pathways to target B cell receptor complexes for degradation AI翻译
  作者：Yiu, Stephanie Pei Tung; Liao, Yifei; Yan, Jinjie; Weekes, Michael P.; Gewurz, Benjamin E.
  作者单位：Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute; Harvard University; Harvard Medical School; University of Cambridge
  摘要：Epstein-Barr virus (EBV) establishes persistent infection, causes infectious mononucleosis, is a major trigger for multiple sclerosis and contributes to multiple cancers. Yet, knowledge remains incomplete about how the virus remodels host B cells to support lytic replication. We previously identified that EBV lytic replication results in selective depletion of plasma membrane (PM) B cell receptor (BCR) complexes, composed of immunoglobulin and the CD79A and CD79B signaling chains. Here, we use...
• Microfluidic purification of genomic DNA AI翻译
  作者：Wang, Jiayi; Butler, Jason E.; Ladd, Anthony J. C.
  作者单位：State University System of Florida; University of Florida
  摘要：migration of DNA, which occurs when a polyelectrolyte solution flowing through a microfluidic channel is subjected to an electric field. The coupling of the weak shearing with the axial electric field is highly selective for long, flexible, charged molecules, of which DNA is the sole example in a typical cell lysate. As a result of migration to the walls, DNA is held near the channel inlet by electrophoresis (there is no flow near the channel walls), while the remaining components are eluted b...
• Enhancing drug solubility through competitive adsorption on silica nanosurfaces with ultrahigh silanol densities AI翻译
  作者：Xu, Zhuo; Zhu, Changliang; Shen, Hongchuan; Liu, Yuan; Tang, Jiashen; Weitz, David A.; Xu, Lei
  作者单位：Chinese University of Hong Kong; Harvard University; Harvard University
  摘要：We develop a technology based on competitive adsorption between drug molecules and water, specifically designed to address the critical issue of poor drug solubility. By specially engineering silica nanosurfaces with ultrahigh densities of silanol, we significantly enhance their affinity for both drug molecules and water, with a notably greater increase in water affinity. Such surfaces can effectively adsorb a variety of drug molecules under dry conditions. Upon exposure to water, these surfac...
• Calcineurin governs baseline and homeostatic regulations of non-rapid eye movement sleep in mice AI翻译
  作者：Yin, Xin; Zhang, Zihan; Zhou, Rui; Zuo, Peng; Sang, Di; Zhou, Shuang; Shi, Bihan; Chen, Lin; Wu, Chongyang; Guo, Ying; Wang, Fengchao; Zhang, Eric Erquan; Li, Qi; Yanagisawa, Masashi; Liu, Qinghua
  作者单位：Peking University; National Institute of Biological Sciences, Beijing; Chinese Academy of Medical Sciences - Peking Union Medical College; Peking Union Medical College; Tsinghua University; Beijing Normal University; Tsinghua University; University of Tsukuba; Tsinghua University
  摘要：Sleep need accumulates during waking and dissipates during sleep to maintain sleep homeostasis (process S). Besides the regulation of daily (baseline) sleep amount, homeostatic sleep regulation commonly refers to the universal phenomenon that sleep deprivation (SD) causes an increase of sleep need, hence, the amount and intensity of subsequent recovery sleep. The central regulators and signaling pathways that govern the baseline and homeostatic sleep regulations in mammals remain unclear. Here...
• Profile of Geoffrey M. Heal AI翻译
  作者：Langlois, Jill
• Violence against women and girls research: Leveraging gains across disciplines AI翻译
  作者：Falb, Kathryn; Peterman, Amber; Nordas, Ragnhild; Field, Anjalie; Porat, Roni; Stark, Lindsay
  作者单位：Johns Hopkins University; Johns Hopkins Bloomberg School of Public Health; University of North Carolina; University of North Carolina Chapel Hill; University of Michigan System; University of Michigan; Johns Hopkins University; Hebrew University of Jerusalem; Hebrew University of Jerusalem; Washington University (WUSTL)
  摘要：Violence against women and girls (VAWG) is a leading cause of mortality and morbidity worldwide, linked to numerous health, economic, and human rights outcomes. Target 5.2 of the Sustainable Development Goals calls for elimination of all forms of VAWG; however, progress toward achieving this goal has been inadequate. A lack of sufficient data and evidence has hindered global efforts to meet this target and hold governments accountable for action. While there have been substantial advancements ...
• Heterogeneous and multiple conformational transition pathways between pseudoknots of the SARS-CoV-2 frameshift element AI翻译
  作者：Yan, Shuting; Schlick, Tamar
  作者单位：New York University; New York University; New York University; NYU Shanghai; New York University
  摘要：Frameshifting is an essential mechanism employed by many viruses including coronaviruses to produce viral proteins from a compact RNA genome. It is facilitated by specific RNA folds in the frameshift element (FSE), which has emerged as an important therapeutic target. For SARS-CoV-2, a specific 3-stem pseudoknot has been identified to stimulate frameshifting. However, prior studies and our RNA-As-Graphs analysis coupled to chemical reactivity experiments revealed other folds, including a diffe...