4期

最新文章

• Structural insights into glucose-6-phosphate recognition and hydrolysis by human G6PC1 AI翻译
  作者：Xia, Zhanyi; Liu, Chuanyu; Wu, Di; Chen, Huiwen; Zhao, Jun; Jiang, Daohua
  作者单位：Chinese Academy of Sciences; Institute of Physics, CAS; Chinese Academy of Sciences; University of Chinese Academy of Sciences, CAS; Peking University
  摘要：The glucose- 6- phosphatase (G6Pase) is an integral membrane protein that catalyzes the hydrolysis of glucose- 6- phosphate (G6P) in the endoplasmic reticulum lumen and plays a vital role in glucose homeostasis. Dysregulation or genetic mutations of G6Pase are associated with diabetes and glycogen storage disease 1a (GSD- 1a). Studies have characterized the biophysical and biochemical properties of G6Pase; however, the structure and substrate recognition mechanism of G6Pase remain unclear. Her...
• Retrospective SARS- CoV-2 human antibody development trajectories are largely sparse and permissive AI翻译
  作者：Kirby, Monica B.; Petersen, Brian M.; Faris, Jonathan G.; Kells, Siobhan P.; Sprenger, Kayla G.; Whitehead, Timothy A.
  作者单位：University of Colorado System; University of Colorado Boulder
  摘要：Immunological interventions, like vaccinations, are enabled by the predictive control of humoral responses to novel antigens. While the development trajectories for many broadly neutralizing antibodies (bnAbs) have been measured, it is less established how human subtype- specific antibodies develop from their precursors. In this work, we evaluated the retrospective development trajectories for eight anti-SARS-CoV-2 Spike human antibodies (Abs). To mimic the immunological process of BCR selecti...
• Targeting EPHB2/ABL1 restores antitumor immunity in preclinical models of ependymoma AI翻译
  作者：Ren, Jun; Amoozgar, Zohreh; Uccello, Taylor P.; Lei, Pin - Ji; Zhao, Yuhui; Ho, William W.; Huang, Peigen; Kardian, Alisha; Mack, Stephen C.; Duda, Dan G.; Xu, Lei; Jain, Rakesh K.
  作者单位：Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard Medical School; St Jude Children's Research Hospital; St Jude Children's Research Hospital; St Jude Children's Research Hospital; Baylor College of Medicine; AstraZeneca; Sanofi-Aventis; Sanofi USA; Guangdong Medical University; Agency for Science Technology & Research (A*STAR); A*STAR - Singapore Immunology Network (SIgN)
  摘要：Ependymoma (EPN) is a common form of brain tumor in children, often resistant to available cytotoxic therapies. Molecular profiling studies have led to a better understanding of EPN subtypes and revealed a critical role of oncogenes ZFTA-RELA fusion and EPHB2 in supratentorial ependymoma (ST-EPN). However, the immune system's role in tumor progression and response to therapy remains poorly understood. New treatments for various molecular subtypes of EPN are desperately needed. Using ST- EPN-ZF...
• Expert navigators deploy rational complexity-based decision precaching for large- scale real- world planning AI翻译
  作者：Velasco, Pablo Fernandez; Griesbauer, Eva- Maria; Brunec, Iva K.; Morley, Jeremy; Manley, Ed; Mcnamee, Daniel C.; Spiers, Hugo J.
  作者单位：University of London; University College London; University of York - UK; University of Pennsylvania; University of Leeds; University of London; University College London
  摘要：Efficient planning is a distinctive hallmark of intelligence in humans, who routinely make rapid inferences over complex world contexts. However, studies investigating how humans accomplish this tend to focus on naive participants engaged in simplistic tasks with small state spaces, which do not reflect the intricacy, ecological validity, and human specialization in real- world planning. In this study, we examine the street- by- street route planning of London taxi drivers navigating across mo...
• Preventing inappropriate signals pre- and post- ligand perception by a toggle switch mechanism of ERECTA AI翻译
  作者：Chen, Liangliang; Maes, Michal; Cochran, Alicia M.; Avila, Julian R.; Derbyshire, Paul; Sklenar, Jan; Haas, Kelsey M.; Villen, Judit; Menke, Frank L. H.; Torii, Keiko U.
  作者单位：Howard Hughes Medical Institute; University of Texas System; University of Texas Austin; University of Texas System; University of Texas Austin; Howard Hughes Medical Institute; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; UK Research & Innovation (UKRI); Biotechnology and Biological Sciences Research Council (BBSRC); John Innes Center; University of East Anglia; University of Washington; University of Washington Seattle; University of Washington; University of Washington Seattle; Harvard University; Massachusetts Institute of Technology (MIT); Broad Institute
  摘要：Dynamic control of signaling events requires swift regulation of receptors at an active state. By focusing on the Arabidopsis ERECTA (ER) receptor kinase, which perceives peptide ligands to control multiple developmental processes, we report a mechanism preventing inappropriate receptor activity. The ER C- terminal tail (ER_CT) functions as an autoinhibitory domain: Its removal confers higher kinase activity and hyperactivity during inflorescence and stomatal development. ER_CT is required for...
• Symmetry facilitated the evolution of heterospecificity and high- order stoichiometry in vertebrate hemoglobin AI翻译
  作者：Cortez-Romero, Carlos R.; Lyu, Jixing; Pillai, Arvind S.; Laganowsky, Arthur; Thornton, Joseph W.
  作者单位：University of Chicago; Texas A&M University System; Texas A&M University College Station; University of Chicago; University of Washington; University of Washington Seattle; University of Chicago
  摘要：Many proteins form paralogous multimers-molecular complexes in which evolutionarily related proteins are arranged into specific quaternary structures. Little is known about the mechanisms by which they acquired their stoichiometry (the number of total subunits in the complex) and heterospecificity (the preference of subunits for their paralogs rather than other copies of the same protein). Here, we use ancestral protein reconstruction and biochemical experiments to study historical increases i...
• An analytical model of label-free nanoscale chemical imaging reveals avenues toward improved spatial resolution and sensitivity AI翻译
  作者：Zhang, Yide; Yilmaz, Ufuk; Lukasievicz, Gustavo Vinicius Bassi; O'Faolain, Liam; Lendl, Bernhard; Ramer, Georg
  作者单位：Technische Universitat Wien; Universidade Tecnologica Federal do Parana; Technische Universitat Wien
  摘要：Atomic force microscopy-infrared spectroscopy (AFM-IR) is a photothermal scanning probe technique that combines nanoscale spatial resolution with the chemical analysis capability of mid-infrared spectroscopy. Using this hybrid technique, chemical identification down to the single molecule level has been demonstrated. However, the mechanism at the heart of AFM-IR, the transduction of local photothermal heating to cantilever deflection, is still not fully understood. Existing physical models onl...
• Removal by the fittest in ocean dead zones AI翻译
  作者：Beman, J. M.
  作者单位：University of California System; University of California Merced; University of California System; University of California Merced
• The perceptual primacy of feeling: Affectless visual machines explain a majority of variance in human visually evoked affect AI翻译
  作者：Conwell, Colin; Graham, Daniel; Boccagno, Chelsea; Vessel, Edward A.
  作者单位：Harvard University; Hobart & William Smith Colleges; Harvard University; Harvard University Medical Affiliates; Massachusetts General Hospital; Harvard University; Harvard T.H. Chan School of Public Health; City University of New York (CUNY) System; City College of New York (CUNY)
  摘要：Looking at the world often involves not just seeing things, but feeling things. Modern feedforward machine vision systems that learn to perceive the world in the absence of active physiology, deliberative thought, or any form of feedback that resembles human affective experience offer tools to demystify the relationship between seeing and feeling, and to assess how much of visually evoked affective experiences may be a straightforward function of representation learning over natural image stat...
• Spreading dynamics of information on online social networks AI翻译
  作者：Meng, Fanhui; Xie, Jiarong; Sun, Jiachen; Xu, Cong; Zeng, Yutian; Wang, Xiangrong; Jia, Tao; Huang, Shuhong; Deng, Youjin; Hu, Yanqing
  作者单位：Sun Yat Sen University; Beijing Normal University; Beijing Normal University; Sun Yat Sen University; Southern University of Science & Technology; Shenzhen University; Chongqing Normal University; Southwest University - China; Technical University of Munich; Chinese Academy of Sciences; University of Science & Technology of China, CAS; Minjiang University; Southern University of Science & Technology
  摘要：Social media is profoundly changing our society with its unprecedented spreading power. Due to the complexity of human behaviors and the diversity of massive messages, the information-spreading dynamics are complicated, and the reported mechanisms are different and even controversial. Based on data from mainstream social media platforms, including WeChat, Weibo, and Twitter, cumulatively encompassing a total of 7.45 billion users, we uncover a ubiquitous mechanism that the information- spreadi...